Publications by authors named "Hai-Jing Yang"
Objective: To compare the pharmacokinetic (PK) characteristics, investigate relative bioavailability, and provide data for potential additional bioequivalence trials between generic fidaxomicin (test (T) formulation) and the original brand (reference (R) formulation) in healthy Chinese subjects.
Materials And Methods: An open, randomized, single-dose, cross-over study was conducted in 18 healthy Chinese subjects. The subjects randomly received T or R formulations and the alternative formulations were received after a 14-day wash-out period.
(a) To evaluate the efficacy and safety of narrow-band intense-pulsed light (DPL) in immediate post-operative scar. (b) To observe the process of scar formation under dermoscopy in the first 6 months. Nine patients with postoperative scars were enrolled in the randomized, prospective, split-scar study.
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- Amphotericin B colloidal dispersion (ABCD) is a safer version of amphotericin B used to treat serious fungal infections, and a study was done to assess its safety and pharmacokinetics (PK) in healthy Chinese subjects.
- The researchers developed a population PK model to predict how standard doses (3 or 4 mg/kg) would perform in infected patients, using Monte Carlo simulations to analyze effectiveness against Candida albicans.
- Findings showed that administering ABCD at doses of 3 or 4 mg/kg resulted in high efficacy rates (over 98% effective) in significantly reducing Candida albicans and that these doses are suitable for treating invasive fungal infections.
Objectives: This study aimed to evaluate the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting bowel inflammation in patients with Crohn disease (CD).
Methods: Sixteen patients who underwent intravoxel incoherent motion DW-MRI for CD and colonoscopy were recruited. Seventy-nine bowel segments were selected, and their mean D, D*, f, and apparent diffusion coefficient (ADC) values were measured.
Aim: This study examined the predictors of loss to follow-up in long-term supportive periodontal therapy in patients with chronic periodontitis.
Methods: A total of 280 patients with moderate to severe chronic periodontitis in a tertiary care hospital in China were investigated and followed over the course of study. Questionnaires on clinical and demographic characteristics, self-efficacy for oral self-care and dental fear at baseline were completed.
Objective: The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and F-FDG accumulation in pancreatic cancer.
Methods: Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue and adjacent normal tissue was performed for Glut-1 and HK-II.
Objective: To study the effect of recombinant Lactobacillus casei (L.casei) expressing interleukin (IL)-10 combined with 5-aminosalicylic acid (5-ASA) in dextran sulfate sodium (DSS)-induced colitis mice.
Methods: Recombinant L.