Publications by authors named "Hai-Dong Ma"
Article Synopsis
- Extrahepatic cholangiocarcinoma sarcoma is a very rare cancer type that features both epithelial and mesenchymal cells, making it difficult to study due to the lack of available cell lines.
- The primary aim of the research was to create and characterize a new cell line called CBC2T-2, utilizing various methods like STR testing, cloning assays, and tumorigenicity tests in mice to understand its properties and potential for therapeutic research.
- Results confirmed the authenticity of the CBC2T-2 line, revealing unique cellular characteristics including high proliferation, migratory and invasive abilities, and distinct chromosomal structures that can aid in further studies on cholangiocarcinoma sarcoma treatments.
Article Synopsis
- * This study focused on five cardiac glycosides extracted from plants, with lanatoside C (Lan C) identified as the most effective in inhibiting the growth and inducing apoptosis in CCA cells.
- * The mechanism of Lan C's anticancer activity involved increasing reactive oxygen species, altering mitochondrial potential, and modulating specific protein expressions, ultimately leading to reduced tumor growth without harming normal cells.
[Study on Platelet Adhesion and Aggregation Induced by Gradient Shear Stress Using Microfluidic Chip Technology].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2023
Objective: To study the effect of gradient shear stress on platelet aggregation by microfluidic chip Technology.
Methods: Microfluidic chip was used to simulate 80% fixed stenotic microchannel, and the hydrodynamic behavior of the stenotic microchannel model was analyzed by the finite element analysis module of sollidwork software. Microfluidic chip was used to analyze the adhesion and aggregation behavior of platelets in patients with different diseases, and flow cytometry was used to detect expression of the platelet activation marker CD62p.