Publications by authors named "Hai-Cheng Li"
Purpose: To explore the role of quantitative plaque analysis and fractional flow reserve (CT-FFR) derived from coronary computed angiography (CCTA) in evaluating plaque progression (PP).
Methods: A total of 248 consecutive patients who underwent serial CCTA examinations were enrolled. All patients' images were analyzed quantitatively by plaque analysis software.
Article Synopsis
- Drug-resistant Mycobacterium tuberculosis has become a major public health issue, complicating tuberculosis treatment, and the study explores the molecular mechanisms behind levofloxacin resistance.
- Through transcriptome and methylome sequencing, the research identified significant changes in gene expression and DNA methylation associated with levofloxacin resistance, revealing 953 differentially expressed genes and 239 differentially methylated genes.
- Key overlapping genes were discovered that could play crucial roles in the resistance mechanisms, particularly genes like cyp132, pckA, and pfkB, which may help inform future TB treatment strategies.
Previous studies have reported that genome-wide DNA methylation and differentially expressed genes and proteins are closely associated with drug resistance in Mycobacterium tuberculosis (M. tuberculosis). However, no reports have explored such associations in para-aminosalicylic acid (PAS)-resistant M.
View Article and Find Full Text PDF[Adriamycin or adriamycin-Fe3+ induced bovine serum albumin damage].
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
March 2003
ESR spectroscopy was used to investigate the production of reactive oxygen radicals in adriamycin (ADM) and its iron complex. The results showed that ADM-Fe(3+) induced the production of oxygen radicals more efficiently than ADM. The damage of BSA mediated by ADM or ADM-Fe(3+) was investigated by measuring the increase of reactive carbonyl content and the decrease of the fluorescence intensity of the Trp residue.
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