Publications by authors named "Hai Zhong Zhang"

The skin redraping method for medial epicanthoplasty is characterized by some shortcomings which warrants modification. In this study, clinical data of 193 patients who underwent medial epichanthoplasty by the modified skin redraping technique or the classic skin redraping technique were reviewed retrospectively. The patients underwent operation between May 2018 and June 2020 and were followed up for not less than 6 months.

View Article and Find Full Text PDF

Background: The casein kinase 2-interacting protein-1 (CKIP-1) is important in the development of osteoblasts and cardiomyocytes. However, the effects of CKIP-1 on osteoblast precursor mesenchymal stem cells (MSCs) remain unclear. This study aimed to determine whether CKIP-1 affects osteogenic differentiation in MSCs and explore the relationship of CKIP-1 and inflammation.

View Article and Find Full Text PDF
Article Synopsis
  • Research highlights the important role of circRNAs, specifically circFLNA, in laryngeal squamous cell carcinoma (LSCC) metastasis.
  • Scientists found that higher levels of circFLNA are linked to lymph node metastasis and enhanced cell migration in LSCC.
  • The study reveals a regulatory mechanism where circFLNA interacts with miR-486-3p, leading to increased FLNA protein expression, suggesting that targeting this pathway could be a new treatment strategy.
View Article and Find Full Text PDF

Objective: To evaluate the effectiveness and complications of an ultrasound-aided biodegradable osteosynthesis system in the treatment of midfacial fractures.

Methods: From January 1, 2010 to March 1, 2013, a total of 193 midfacial fractures patients were recruited. There were 120 males and 73 females.

View Article and Find Full Text PDF

Objective: To evaluate the efficacy and safety of brachytherapy plus operation for salivary gland malignant tumors.

Methods: From June 2006 to June 2011, a total of 105 patients with salivary gland malignant tumors undergone brachytherapy by implantation of iodine 125 seeds. The effectiveness was evaluated by periodical radiological film and computed tomography.

View Article and Find Full Text PDF

Objective: To evaluate the feasibility of MRI navigation in identifing the safe surgical margin of the maxillofacial malignancy.

Methods: The pathology results of the surgical margin identified by the technique of MRI navigation form 20 patients with maxillofacial malignancy were compared with those of 45 patients with maxillofacial malignancy who underwent the routine operation without MRI navigation.

Results: There was no difference between the two groups of patients in age, sex, size of tumor, tumor stages, pathologic diagnosis (P > 0.

View Article and Find Full Text PDF

Objective: To explore the biological features and clinical efficacies of absorbable plates and screws for rigid internal fixation.

Methods: From June 2006 to June 2010, 201 FIXSORB(TM)-MX absorbable plates were used in 57 patients, including 41 males and 16 females aged from 11 - 81 years. And 185 plates were used in 53 patients of maxillofacial fracture and 16 plates in 4 undergoing orthognathic operations with rigid internal fixation.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess the effectiveness of rigid internal fixation using resorbable bone plates for treating zygomatic arch fractures through a modified preauricular-temporal approach.
  • A total of twenty patients (ages 14-68) were analyzed, with most having unilateral comminuted fractures, and the procedure aimed to restore the arch's original form with minimal scarring.
  • Results showed successful fracture reduction, no complications like limited mouth opening or facial palsy, and the resorbable plates were not noticeable one year post-surgery, indicating this method is effective for such fractures.
View Article and Find Full Text PDF

Objective: To investigate the clinical efficacy between mobile intraoperative magnetic resonance imaging (iMRI) navigation with a high field strength and routine surgical resection for malignancy of parapharyngeal space.

Methods: The surgical efficacy indexes of patients at our hospital during the time range from February 2010 to February 2011 were compared between two groups consisting of 29 or 42 individuals undergoing surgery with the assistance of the technique of iMRI navigation with a high field strength 1.5T or routine operation.

View Article and Find Full Text PDF

Purpose: The epidermal growth factor receptor (EGFR) is one of the four human epidermal receptors. The efficacy and safety of EGFR-targeted therapies for treating non-small-cell lung cancer (NSCLC) remained controversial. The aim of this study was to systematically evaluate EGFR-targeted therapies plus chemotherapy for advanced NSCLC.

View Article and Find Full Text PDF

In this letter, it is proposed that the usage of Al(2)O(3) capping layer can tremendously improve the phase stability of SnO thin films, which allows the accurate determination of the optical constants of the SnO films without the perturbation arising from impurity phases. For the SnO films, the refraction index and extinction coefficient are significantly influenced by the crystallinity. The nondirect optical bandgap of the amorphous SnO films is determined to be 2.

View Article and Find Full Text PDF

Objective: To explore the capability of human periodontal ligament stem cells (PDLSCs) differentiating into adipose cells in vitro and to determine their changes in cell morphology, structure and function during differentiation.

Methods: PDLSCs isolated by magnetic-activated cell selection were treated continuously with adipogenic medium for 21 d. Then the cell morphology, ultrastructure, adipose specific markers of low density lipoprotein (LPL) and peroxisome proliferator activated receptor-gamma (PPAR-gamma) were analyzed by inverted contrast microscope, trans mission electron microscope (TEM), flow cytometry, immunofluorescence, RT-PCR and Western blot, respectively.

View Article and Find Full Text PDF

Objective: To evaluate the clinical value of neuronavigation system in stomatology.

Methods: The clinical data of 3 patients were reviewed. Thin-slice CT scanning was conducted on the 3 patients and the CT data were input into the CT neuronavigation system that in turn guided the operations later.

View Article and Find Full Text PDF

Objective: To investigate the biomechanical changes with different directions distraction at midface.

Methods: An anteriorly directed 500 g force was applied to the floor of apertura piriforms in different directions to the occlusal plane. Three-dimensional finite element analysis was used to evaluate the biomechanical change of craniofacial complex.

View Article and Find Full Text PDF

Objective: Monoclonal antibody (mAb) conjugated with certain toxin to generate immunotoxin bears an important and promising effect as a new therapy for patients with hematopoietic malignancies. However, most toxic moieties conjugated with antibody proteins reported in the literature were toxic proteins which presented immunogenicity to patients capable of inducing anti-toxin antibody. Norcantharidin (NCTD) is a small molecule toxin.

View Article and Find Full Text PDF

Objective: To study the endogenous hormone of testosterone and cortisol that secretes volume and rhythm in sports fatigued human bodies and animals. To determine secretory volume and rhythm in sports fatigued human bodies and animals when Shixiang yaofa's drug are used.

Method: Radio-immunity method was used to determine secretory volume and rhythm in sports fatigued human bodies and animals and to analyze secretory volume and rhythm.

View Article and Find Full Text PDF

Objective: The purpose of this study was to investigate the biomechanical changes of midface skeleton protraction at its medium position in the craniofacial complex, using the three-dimensional finite element method (FEM).

Methods: A three-dimensional FEM model was developed from the CT scan images by the technologies of three-dimensional reconstruction, image processing and meshing. The protraction forces were applied to the following locations: the first molar, full maxillary arch, and the floor of aperture piriforms.

View Article and Find Full Text PDF

Objective: The purpose of this study was to establish the constructive of craniofacial suture in the three-dimensional finite element model of craniofacial complex in child, to analyse the response procedure of the zygomatic impact, to explore the biomechanics characteristic of the children craniofacial trauma.

Methods: A 7-year-old female was adopted for study The complex cranial geometry was measured from a series of two-dimensional CT images. The multi-lay spiral CT scans were transformed with a self-developed preprocessor into a finite element mesh.

View Article and Find Full Text PDF

Objective: The three-dimensional (3D) craniofacial measurements were studied through the quantitative computed tomography (CT). The dynamic database of quantitative measurement of three-dimensional craniofacial bone was established as mandible in physiological position.

Methods: 170 aesthetics female were examined by spiral volumetric CT (GE SR-7000).

View Article and Find Full Text PDF

ZCH-2B8a (IgG2a) is a novel monoclonal antibody (McAb) generated in laboratory of Children Hospital of Medical College, Zhejiang University recently using human myeloblastic leukemia cell line KG1a as immunogen. This antibody has been submitted to the 8th International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA8) and the results showed that the antibody recognized an unknown molecule on the surface of some blood cells. The aim of this study was to investigate the reactivity of this antibody on normal blood cells and malignant cell lines and to explore its possible application in clinical practice.

View Article and Find Full Text PDF

Objective: To analyze the reactive pattern and its clinical significance of ZCH-7-2D3 monoclonal antibody on leukemia cells.

Methods: Bone marrow samples from 100 leukemia patients (male 59: female 41, 34 cases of children and 66 adults, aged 11 months - 77 year) were collected. A CD45 gating strategy and multi-parameter flow cytometry were used to analyze the leukemia cells.

View Article and Find Full Text PDF

Objective: The purpose of this study was to explore suppositional sutural construction and protraction in the three-dimensional finite element model of craniofacial complex.

Methods: Combining spiral CT scanning technology with the three-dimensional finite element method, three-dimensional FEM model of craniofacial complex was developed for analysis. In the model, craniofacial sutures were constructed through the MSC.

View Article and Find Full Text PDF

Objective: To explore the factor of age related to protraction response.

Methods: Four 12-week mongrel dogs in the same nest were randomly assigned into two groups: the control (n = 1) and the experimental groups (n = 3). Four pairs of titanium bone markers were fixed on either side of the bone sutures of all animals.

View Article and Find Full Text PDF

Objective: To probe the possibility of trans-sutural distraction osteogenesis for correction of children midfacial hypoplasia.

Methods: The trans-sutural distraction system of mid-facial skeleton consisted of the bone-borne traction hooks of titanium, the face-bow, and the elastic loops. Nine children with midfacial hypoplasia were treated at their 6 - 12 years of age.

View Article and Find Full Text PDF