Comparative analysis of the complete chloroplast genome of Pueraria provides insights for species identification, phylogenetic relationships, and taxonomy.

Background: Pueraria is an edible and medicinal raw material, which is of great value to the pharmaceutical and food industries. Nonetheless, due to morphological diversity and complex domestication history, the classification of Pueraria plants is ambiguous. As the varieties on the market are mixed, the species are difficult to distinguish, and their morphological characteristics are similar to the physical and chemical properties.

Controllable Active Intermediate in CO Hydrogenation Enabling Highly Selective ,-Dimethylformamide Synthesis via -Formylation.

,-Dimethylformamide (DMF) is a widely used solvent, and its green and low-carbon synthesis methods are in high demand. Herein, we report a new approach for DMF synthesis using a continuous flow reaction system with a fixed-bed reactor and a ZnO-TiO solid solution catalyst. This catalyst effectively utilizes CO, H, and dimethylamine (DMA) as feedstocks, demonstrating performance with 99% DMF selectivity and single-pass DMA conversion approaching thermodynamic equilibrium.

[Prognostic value of albumin and aspartate aminotransferase/alanine aminotransferase ratio in patients with acute liver failure in hyperacute phase of sepsis: a multicenter retrospective cohort study].

Objective: To investigate the prognostic value of albumin (ALB), aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT) in patients with acute liver failure (ALF) in hyperacute phase of sepsis which provided the basis for clinical evaluation and prognostic judgment and corresponding treatment options.

Methods: A multicenter retrospective cohort study was conducted. Patients with ALF in hyperacute phase of sepsis admitted to Zhoupu Hospital Affiliated to Shanghai Health College, Shanghai Pudong New Area People's Hospital, and Shanghai Oriental Hospital from January 2019 to February 2024 were enrolled.

Factors associated with postoperative coronal imbalance in adult patients with severe and rigid scoliosis: a retrospective study.

Background: Extensive studies examined coronal imbalance (CIB) in adolescent and adult degenerative scoliosis; however, few studies addresses on CIB in adult with severe rigid scoliosis (SRS). Therefore, we analyzed postoperative SRS patients to identify factors associated with postoperative CIB.

Methods: In this retrospective study, we investigated SRS patients undergoing one-stage posterior column osteotomy (PCO) and fusion at our hospital between August 2012 and January 2019.

Comparison of clinical outcomes between direct and indirect transfer in patients with ST-segment elevation myocardial infarction.

Primary percutaneous coronary intervention (PCI) is the cornerstone of treatment for ST-segment elevation myocardial infarction (STEMI). Previous studies suggest that direct transport by ambulance to a primary PCI facility is associated with better clinical outcomes in patients with STEMI. However, those studies included seriously ill patients for whom direct transport is the only option.

Signatures of Six Autophagy-Related Genes as Diagnostic Markers of Thyroid-Associated Ophthalmopathy and Their Correlation With Immune Infiltration.

Background: Thyroid-associated ophthalmopathy (TAO) is one of the most complex autoimmune diseases in endocrinology areas. Autophagy-related genes may be involved in the pathophysiology of TAO. This study aims to reveal key genes associated with autophagy in the pathogenesis and the potential diagnostic markers for TAO.

Association between various types of corticosteroids and mortality for severe community-acquired pneumonia in adults: a systematic review and network meta-analysis.

Objective: This study aims to conduct a systematic review and network meta-analysis to evaluate the efficacy and safety of specific corticosteroids, including but not limited to hydrocortisone, methylprednisolone, prednisolone, and dexamethasone, in the treatment of severe community-acquired pneumonia (SCAP). Efficacy will be assessed using specific outcomes, such as 30-day mortality and the requirement for mechanical ventilation. Safety evaluations will include adverse events like gastrointestinal bleeding and healthcare-associated infections.

Molecular Basis for Cγ-N Bond Formation by PLP-Dependent Enzyme LolC.

Pyridoxal 5'-phosphate (PLP)-dependent enzymes catalyze a diverse array of biochemical transformations, making them invaluable biocatalytic tools for the synthesis of complex bioactive compounds. Here, we report the biochemical characterization of LolC, a PLP-dependent γ-synthase involved in the biosynthesis of loline alkaloids. LolC catalyzes the formation of a Cγ-N bond between -acetyl--homoserine (OAH) and l-proline, generating a diamino diacid intermediate.

Doping Ti into RuO to Accelerate Bridged-Oxygen-Assisted Deprotonation for Acidic Oxygen Evolution Reaction.

The development of efficient and durable electrocatalysts for the acidic oxygen evolution reaction (OER) is essential for advancing renewable hydrogen energy technology. However, the slow deprotonation kinetics of oxo-intermediates, involving the four proton-coupled electron steps, hinder the acidic OER progress. Herein, a RuTiO solid solution electrocatalyst is investigated, which features bridged oxygen (O) sites that act as proton acceptors, accelerating the deprotonation of oxo-intermediates.

Primary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.

Background: Liposarcoma (LPS) is a kind of malignancy of soft tissue usually found in the retroperitoneal, limb, or neck region, and some may be detected with delayed symptoms (pain or palpable mass), and less frequently occurs in organs of the digestive system. In contrast, Dedifferentiated liposarcoma (DDLPS) is a common histological subtype of LPS. The present study reported a case of dedifferentiated liposarcoma originating in the gallbladder.

Amorphous NiB Promotes Electroreduction of Nitrate to Ammonia.

The electrocatalytic nitrate reduction to ammonia (NRA) can address nitrogen cycle imbalance and high carbon emissions; however, the intense competition of hydrogen evolution reaction (HER) restricts the rate of NH production. Herein, amorphous NiB (a-NiB) is designed to balance the NRA and HER. The NH yield of a-NiB surpasses those of pure Ni and NiO, which is attributed to the preferential adsorption of NO on the B and Ni sites of a-NiB for the NRA reaction, greatly inhibiting the HER.

Incidence and Risk Factors of Lumbosacral Complications Following Long-Segment Spinal Fusion in Adult Degenerative Scoliosis.

Purpose: Long-segment spinal fusions are associated with lumbosacral complications (LSC), but the associated risk factors are not known. This study aimed to identify the risk factors for LSC after long-segment instrumented fusion with distal fixation to the L5 vertebral body in adult degenerative scoliosis (ADS).

Methods: We retrospectively evaluated 294 patients with ADS who underwent long-segment floating fusion between January 2014 and March 2022, with follow-up for at least 2 years.

Prehospital blood pressure lowering in patients with ischemic stroke: A systematic review and meta-analysis of randomized controlled trials.

Background: Whether prehospital blood pressure control improves outcomes among patients with acute ischemic stroke is uncertain. This systematic review and meta-analysis aimed to evaluate the effect of prehospital blood pressure reduction treatment in patients with ischemic stroke.

Methods: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for randomized controlled trials that compared prehospital blood pressure reduction treatment with usual treatment or no treatment in patients with stroke.

Expert consensus on the clinical application of cortical bone trajectory for lumbar pedicle screws: results from a modified Delphi study.

Study Design: A modified Delphi study.

Purpose: This study sought to establish expert consensus on the use of cortical bone trajectory (CBT) for lumbar pedicle screws.

Overview Of Literature: The CBT technique is widely used in the treatment of various degenerative lumbar diseases because it reduces surgical time, soft tissue exposure, and blood loss; improves biomechanical stability; and allows for faster patient recovery.

Biosynthesis of the α-D-Mannosidase Inhibitor (-)-Swainsonine.

(-)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against α-D-mannosidases. In this work, we successfully reconstituted swainsonine biosynthetic pathway both in vivo and in vitro. Our study unveiled a surprising epimerization mechanism involving an imine reductase (SwnN) and two non-heme iron and α-ketoglutarate-dependent oxygenases (SwnH2 and SwnH1).

Preoperative halo-gravity traction combined with one-stage posterior spinal fusion surgery following for severe rigid scoliosis with pulmonary dysfunction: a cohort study.

Background: To assess the efficacy of preoperative halo-gravity traction (HGT) in treating severe spinal deformities, evaluating radiological outcomes, pulmonary function, and nutritional status.

Methods: This study retrospectively included 33 patients with severe spinal deformity who were admitted to our department from April 2018 to January 2022. All the patients underwent HGT prior to the posterior spinal fusion corrective surgery, with no patients having undergone anterior or posterior release procedures.

Occupational exposure protection and perioperative management of sudden infectious diseases from the perspective of COVID-19.

The coronavirus disease (COVID-19) SARS-CoV-2 virus epidemic continues to exhibit a sporadic onset trend due to the continuous variation of the novel coronavirus. However, the psychological impact of the pandemic persists. It is crucial to reflect on our experiences to better prepare for future large-scale infectious diseases.

Effect of cemented vs uncemented on outcomes for hemiarthroplasty in the elderly: A meta-analysis of randomized clinical trials.

Purpose: In patients undergoing hemiarthroplasty in the elderly, the choice of the cemented method remains controversial. This meta-analysis was undertaken to compare the impact of cemented vs uncemented on outcomes for hemiarthroplasty in the elderly.

Methods: This study included randomized controlled trials comparing the postoperative effects of cemented vs uncemented in patients with hemiarthroplasty.

Molecular Control of the Donor/Acceptor Interface Suppresses Charge Recombination Enabling High-Efficiency Single-Component Organic Solar Cells.

Single-component organic solar cells based on double cable polymers have achieved remarkable performance, with DCPY2 reaching a high efficiency of over 13%. In this study, DCPY2 is further optimized with an efficiency of 13.85%, maintaining a high fill factor (FF) without compromising the short circuit current.

Comparison of thyroid surgery techniques: a retrospective cohort study and meta-analysis of traditional electric knife straight bipolar electrocoagulation forceps.

Background: In recent years, advancements in surgical techniques for thyroidectomy have led to varying outcomes and efficiencies. Understanding these differences is crucial to optimize patient care and surgical success. This study compared intra- and postoperative parameters of thyroid surgery for thyroidectomy or thyroid cancer.