In vitro Biological Evaluation and In silico Studies of a New Anthraquinone from Zingiber cassumunar Roxb. in Type 2 Diabetes Management.

A novel diphenyl-anthraquinone compound, cassuquinone A, was isolated from the rhizomes of Zingiber cassumunar. Structural elucidation was accomplished using detailed NMR and HRMS-ESI  techniques, revealing a symmetrical anthraquinone core with methoxylated aromatic rings. Cassuquinone A exhibited potent α-glucosidase inhibitory activity with an IC₅₀ of 11.

Three undescribed phenylbutenoids derivatives from Roxb. rhizomes and their biological activities.

Phenylbutenoids belong to polyphenolic compounds that have demonstrated distinctive biological activities and are primarily characterised in the genus Zingiber (Zingiberaceae) species. From the EtOAc extract of the rhizomes of Roxb., three phenylbutenoid-type compounds, cassudimin B (), cassumunol O (), and cassumunol P (), were isolated, along with five known compounds (-).

biological evaluation and studies of linear diarylheptanoids from Salisb. as urease inhibitors.

Plants of the family, specifically those belonging to the species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9).

A novel diphenylbutenoid-type compound from the rhizomes of (J.Koenig) Link ex A.Dietr. (Zingiberaceae).

From the EtOAc-soluble extract of the rhizomes of (J.Koenig) Link ex A.Dietr.

Taxotrophises A and B, two new polyphenols from the stems of .

From the EtOAc extract of the wood of the stems of (Moraceae), two new secondary metabolites, named taxotrophises A () and B (), were isolated, together with five known compounds (-). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for -glucosidase inhibitory activity.

Strebluses E-H, four new stilbene-like derivatives from the stems of .

Following bioactivity-guided isolation, four new stilbene-like derivatives, named Strebluses E-H, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Their chemical structures were elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. E possesses potent tyrosinase inhibitory activity with an IC value of 0.

A New abeo-Icetexane-Type Diterpenoid from the Stem Barks of Taxus wallichiana.

From a CH Cl -soluble fraction of the stem barks of Taxus wallichiana, one new abeo-icetexane-type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time-dependent density functional theory (TD-DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the new abeo-icetexane-type diterpenoid was proposed.

Paratrimerin Z, an undescribed chromene derivative from the roots of .

From an EtOAc-soluble fraction of the roots of , one undescribed chromene derivative, paratrimerin Z (), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product.

-Tocopherol derivatives from the leaves of L.

From an ethyl acetate-soluble fraction of the leaves of , one new trimeric -tocopherol derivative named as tocomuntin A (), together with three known -tocopherol derivatives (-) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, -tocopherol () was found to have -glucosidase inhibitory activity for the first time (IC, 47.

A new diphenylheptanoid from the rhizomes of .

A phytochemical investigation of the rhizomes of  was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (), together with four known compounds (-). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed -glucosidase inhibitory activity, with the IC values ranging from 35.

Two new derivatives of 8-prenyl-5,7-dihydroxycoumarin from the stems of (S.Vidal) Corn.

From the EtOAc-soluble extract of the stems of (Moraceae), two new secondary metabolites named strebluses A () and B () were isolated. Their chemical structures have been concluded based on the chemical derivatisation and the spectroscopic interpretation. All compounds have been tested for their tyrosinase inhibitory activity.

A new 8,3'-neolignan from Lour.

The phytochemical investigation of the EtOAc-soluble fraction of the aerial parts of Lour. has been carried out to obtain seven compounds, including a new 8,3'-neolignan named solacanin A (). Their chemical structures were elucidated based on the spectroscopic data interpretation.

A new lignan from the stems of Blume (Anacardiaceae).

From the EtOAc-soluble extract of the stems of , one new lignan, (+)-(8,8')-5'-methoxy-4,4'-di--methylsecoisolariciresinol (), together with five known compounds () were isolated. Their structures were elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined based on the Cotton effects in the ECD spectrum.

A new flavanone derivative from the rhizomes of .

From the methanolic extract of the rhizomes of , a new flavanone derivative named (2,7″)-8-(1-phenyl-2-carboxyethyl)pinocembrin () and four known flavonoids (-) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC value of 6.

Decumbic anhydride from the stem barks of (Anacardiaceae).

From an EtOAc-soluble fraction of the stem barks of (Anacardiaceae), decumbic anhydride () and four known compounds - were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of C NMR chemical shifts was carried out to clarify the structure of .

Paratrimerin I, cytotoxic acridone alkaloid from the roots of .

Bioactivity-guided fractionation of the CHCl-soluble extract of the roots of was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.

A new phenylheptanoid from the leaves of L.

Phytochemical study on the EtOAC-soluble extract of the leaves of furnished the isolation of a new phenylheptanoid, gnetumal (), along with five known compounds (-). Their isolation was carried out by using the column chromatography and their structures were elucidated based on the basis of the spectral interpretation. Bioactivity assay of these compounds indicated that gnetumal () and -coumaric acid () possessed more potent tyrosinase inhibitory activity, with IC values of 31.

A new phenolic acid from the wood of .

From the methanol extract of the wood of (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid () and six known compounds (). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for -glucosidase inhibitory activity.

4-Hydroxypanduratin A and Isopanduratin A Inhibit Tumor Necrosis Factor α-Stimulated Gene Expression and the Nuclear Factor κB-Dependent Signaling Pathway in Human Lung Adenocarcinoma A549 Cells.

Tumor necrosis factor α (TNF-α), a pro-inflammatory cytokine, regulates inflammatory and immune responses by up-regulating gene expression in a manner that is dependent on the transcription factor nuclear factor κB (NF-κB). In the present study, we found that 4-hydroxypanduratin A and isopanduratin A, constituents of the rhizomes of Boesenbergia pandurata, inhibited the TNF-α-stimulated up-regulation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells. 4-Hydroxypanduratin A and isopanduratin A also reduced ICAM-1 mRNA expression and NF-κB-responsive luciferase activity in TNF-α-stimulated A549 cells.

Willughbeia cochinchinensis prevents scopolamine-induced deficits in memory, spatial learning, and object recognition in rodents.

Ethnopharmacological Relevance: Willughbeia cochinchinensis (WC) has been used in Vietnamese traditional medicine for the treatment of dementia as well as diarrhea, heartburn, and cutaneous abscess and as a diuretic.

Aim: Alzheimer's disease (AD) is one of the most prevalent diseases in elderly individuals. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors have been widely used to treat patients with AD.

α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.

From a CHCl extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class.

Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.

Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC value of 6.

Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors.

Background: Based on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (), with IC value of 3.

A New Cassane-type Diterpene from the Seed of Caesalpinia sappan.

Phytochemical investigation of the CH2Cl2 extract of the Vietnamese medicinal plant Caesalpinia sappan Linn resulted in the isolation of a new cassane-type diterpene named tomocin I (1). Its chemical structure was determined by NMR spectroscopic and mass spectrometric analysis.