Publications by authors named "Hai Wei Wu"

Introduction: The study was to assess the myocardial protection effects of the histidine-tryptophan-ketoglutarate (HTK) solution and the 4:1 blood cardioplegia (BC) in patients with atrial fibrillation (AF) who were subjected to valvular replacement concomitant with the Cox maze III surgery.

Methods: A cohort of 148 individuals afflicted with AF, who received valve replacement surgery in conjunction with the Cox maze III procedure at our clinic within the period extending from 2015 to 2023, were enrolled. Subsequent to adjustment by propensity score matching (PSM), the patients were categorized into two distinct groups: the HTK group and the BC group.

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Purpose: To investigate the effect of shikonin (SKN) on proliferation, apoptosis, migration and angiogenesis of hemangioma endothelial cell (HemEC).

Methods: CCK-8 and EdU assays were used to detect the effect of SKN on proliferation of HemEC. The effect of SKN on apoptosis of HemEC was detected by flow cytometry.

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Article Synopsis
  • Infantile hemangioma (IH) is the most common benign tumor in infants, potentially originating from hemangioma stem cells (HemSCs), with treatments including beta-blockers, surgery, and novel agents like microRNAs (miRNAs).
  • Researchers used engineered exosomes (E-exos) to deliver the miR-187-3p into HemSCs, assessing their characteristics and effects on HemSC viability and Notch signaling pathways.
  • The study concluded that E-exos can effectively inhibit HemSC proliferation and tube formation by disrupting Notch signaling, paving the way for improved IH treatment strategies.
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  • Infantile hemangiomas (IHs) are common pediatric lesions, and while propranolol is known to be effective for treatment, it has side effects like sleep disturbances; this study explores the safety and efficacy of atenolol, a β1-selective blocker, as an alternative treatment for IHs.* -
  • The study involved 133 patients diagnosed with proliferating IHs, and patients' responses to atenolol therapy were categorized into four groups, ensuring ethical standards were maintained throughout the process.* -
  • Results showed that 96.2% of patients responded positively to atenolol, with better outcomes in younger patients, and 41 patients requiring additional treatment for residual issues; the only minor complications
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Since 2008, oral propranolol has evolved as the first-line therapy for infantile hemangiomas (IHs). Meanwhile, oral atenolol gradually shows comparative effectiveness versus oral propranolol with few side effects. Here, we conducted a mobile internal survey among a group of Chinese clinicians about how they choose the dosage, dose regimen, and dose escalation methods of propranolol and atenolol for the treatment of IH.

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Purpose: To compare the stress distribution of dental implants with different body shapes after maxillary sinus augmentation.

Mrthods: Three different implant models varying in implant shape were investigated in D3-type maxilla. All materials were assumed to be linear elastic, homogenous and isotropic.

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To evaluate the clinical efficacy of concentrated growth factors (CGFs) combined with mineralized collagen (MC) in guided bone regeneration (GBR). A retrospective study involving 29 patients treated with GBR technique, which was performed either CGF and MC complexes or MC alone. Implants were inserted simultaneously and cone-beam computed tomography was taken immediately, at 3 and 6 months postoperation.

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Objectives: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in patients with heart valve disease. Our aim was to summarize our experience and evaluate the efficacy and safety of the Cox maze III procedure combined with valve surgery in patients with AF.

Methods: A retrospective, observational analysis was performed for all consecutive patients underwent maze III procedure combined with valve surgery between October 2015 and June 2019.

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A new species of Cryptinae, Endasys pristiphorae Sheng, sp.n. reared from cocoons of the tenthredinid sawflies Pristiphora erichsonii (Hartig), P.

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Background: Beta-adrenergic receptor antagonists have been the first-line treatment for infantile hemangiomas (IHs); however, monotherapy may fail to achieve sufficient efficacy for certain patients, especially for refractory IHs. The aim of this study was to evaluate the efficacy and safety of the combination of prednisone and beta-adrenergic receptor antagonists for refractory IHs.

Methods: We studied 76 patients with refractory IHs.

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Background/aim: Salivary adenoid cystic carcinoma (SACC) is the most common malignancy of the salivary gland with a poor prognosis and survival. The present study aimed to investigate the role of histone methyltransferase WHSC1 in SACC.

Materials And Methods: Human SACC specimens were evaluated for WHSC1 expression by RT-PCR and immunohistochemistry.

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Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. Oral propranolol has achieved great success in treating IHs since 2008. To minimize the systemic side events caused by oral administration of propranolol, topical timolol started to be applied in the treatment of IHs, especially for superficial lesions.

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Article Synopsis
  • The study aimed to determine how genetic variations in the CYP2D6*10 gene impact serum levels of tamoxifen and its metabolites in breast cancer patients in Asia.
  • A systematic review and meta-analysis of 7 studies with 552 patients revealed that different CYP2D6*10 genotypes affected the levels of metabolites, specifically showing that the CC genotype had higher concentrations of 4-OH-TAM compared to CT/TT genotypes.
  • The findings suggest that CYP2D6*10 polymorphisms play a significant role in tamoxifen metabolism, which is crucial for the drug's effectiveness in treating breast cancer.
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A new genus, Verruca Sheng Sun gen. nov., of the ichneumonid tribe Atrophini, subfamily Banchinae is described for one new species, Verruca dentia Sheng Sun, sp.

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Purpose: A retrospective study was performed to analyze the relationship between uridine diphosphate glucuronosyltransferase 1A1 () / gene polymorphisms and adverse reactions associated with irinotecan (CPT-11)-based chemotherapy. The correlation between polymorphisms and the clinical efficacy of CPT-11 was also analyzed, along with the influence of age and tumor type.

Patients And Methods: Patients administered a CPT-11-based regimen in the Beijing Cancer Hospital from April 2015 to September 2016 were included in our study (n=81).

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Background: Infantile hemangiomas (IHs) are the most common benign vascular tumor of infancy. They occur more frequently in female infants. The cause of hemangioma is currently unknown; however, current studies suggested the importance of estrogen (E2) signaling in hemangioma proliferation.

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The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.

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Objective: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas.

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Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment modality exists for refractory KHE with or without KMP.

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Treatment of microcystic lymphatic malformations (LMs) is still a great challenge to physicians in the field of managing vascular anomalies. Several kinds of treatment have been proposed for microcystic LMs, but the responses to these treatment modalities vary considerably among individuals. The aim of the study was to investigate the safety and efficacy of intralesional injection of pingyangmycin for microcystic LMs located in the deep facial region.

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The paper uses MSR-16 portable multispectral radiometer made in the USA and computes the numbers of the test units by pulling the formula on the radiometer effective observation area, which solves the problem on the uncertain numbers of computing the times on region visible light band spectral radiation ratio M_D. The paper uses CI-310 portable photosynthesis measurement system made by American CID Company and measures the net photosynthetic rate of a group of soybean plant. M_D and C_D are normalized by the normalization method [0,1].

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The parasitic zoonoses cysticercosis/taeniasis is among the 17 major Neglected Tropical Diseases (NTDs) identified by the WHO as a focus for research and control. It is caused by a larval stage (cysticercus) infection of Taenia solium tapeworm in both humans and pigs. Cysticercosis occurs in many resource-poor countries, especially those with warm and mild climates in the regions of Latin America (LA), Asia and Sub-Saharan Africa (SSA).

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Acute lung injury (ALI) was one of the major complications after cardiopulmonary bypass (CPB). Matrix metalloproteinases (MMPs) play an important role in ALI following CPB. In this study, we investigated the effects of doxycycline (DOX), a potent MMP inhibitor, on MMP-9 and ALI in the rat model of CPB.

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Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1 resulted in a profound parasite replication defect.

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Background: In recent field surveys, we failed to detect the presence of specific antibody against Schistosoma japonicum in some egg-positive patients by commonly used immunodiagnostic kits. To find out whether low levels of specific antibody truly exist among egg-positive individuals and elucidate the underlying immune mechanisms, we carried out a cross-sectional epidemiologic study in a S. japonicum low transmission endemic area of Poyang Lake region, China and compared the humoral and cellular immune characteristics between S.

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