from enhances the stress resistance of transgenic .

Background: (× Ramat.) is a particularly important autumn perennial flower for potted plant, flower bed and border, and cut flower with high ornamental value. However, abiotic stress can affect the ornamental quality of .

Nanotechnology-Enabled Targeted Protein Degradation for Cancer Therapeutics.

Targeted protein degradation (TPD) represents an innovative therapeutic strategy that has garnered considerable attention from both academic and industrial sectors due to its promising developmental prospects. Approximately 85% of human proteins are implicated in disease pathogenesis, and the FDA has approved around 400 drugs targeting these disease-related proteins, predominantly enzymes, transcription factors, and non-enzymatic proteins. However, existing therapeutic modalities fail to address certain "high-value" targets, such as c-Myc and Ras.

Ultra-small Metallic Nickel Nanoparticles on Dealuminated Zeolite for Active and Durable Catalytic Dehydrogenation.

Each step in the catalyst synthesis process plays an important role in tuning the catalyst structures. For zeolite-supported nickel catalysts, we found the conventional calcination-reduction method typically leads to the formation of large nickel particles, but a pre-aging in hydrogen or nitrogen at a low temperature prior to final reduction can result in ultra-small nickel nanoparticles in a metallic state. This pre-aging treatment facilitates the interaction between Ni cations and silanol nests on zeolite before the decomposition of the metal salt, leading to the formation of nanoparticles with an average diameter of ~1.

Highway Safety with an Intelligent Headlight System for Improved Nighttime Driving.

Automotive headlights are crucial for nighttime driving, but accidents frequently occur when drivers fail to dim their high beams in the presence of oncoming vehicles, causing temporary blindness and increasing the risk of collisions. To address this problem, the current study developed an intelligent headlight system using a sensor-based approach to control headlight beam intensity. This system is designed to distinguish between various light sources, including streetlights, building lights, and moving vehicle lights.

Skeletal Nitrogen Functionalization of Isostructural 2D Conjugated MOFs for Enhancement of the Dual-Ion Storage Capacity.

Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) are emerging as promising electrode materials for electrochemical energy storage devices. However, a viable path to realize superior dual-ion storage in 2D c-MOFs has remained elusive. Here, we report the synthesis of Cu(N-OHPTP) 2D c-MOFs (x=0,1,2; OHPTP=octahydroxyphenanthrotriphenylene) with precise aromatic carbon-nitrogen arrangements, based on the π-conjugated OHPTP ligand incorporated with one or two nitrogen atoms.

Evaluation of the Neuroprotective Effect of Total Glycosides of and Investigation of Novel Brain-Targeting Natural MAO-B Inhibitors.

In this study, we investigated the role of total glycosides of (TC) in MPTP-induced neuronal injury. Further, we screened potential inhibitory components of monoamine oxidase B (MAO-B). The study results indicate that TC may improve movement disorders and apoptosis of dopamine (DA) neurons by inhibiting MAO-B activity while reducing the number of glial cells, adjusting the metabolism level of monoamine neurotransmitters, and lowering inflammation and oxidative stress levels.

Differential bone morphology and hypoxia activity in skeletal metastases of ER and ER breast cancer.

Bone metastases occur in the majority of advanced breast cancer patients, and the most common complications are osteolytic bone metastases. However, due to the limitations of models and methodologies for bone metastasis studies, the intricacies of bone metastasis have not been fully acknowledged and revealed in prior work. Our earlier study indicated that certain breast cancer cells undergo a pre-osteolytic stage before the establishment of overt metastatic lesions.

High Charge Carrier Mobility in Porphyrin Nanoribbons.

Polydisperse edge-fused nickel(II) porphyrin nanoribbons have been synthesized by Yamamoto coupling followed by gold(III)-mediated fusion, with average degrees of polymerization of up to 37 repeat units (length 31 nm). Time-resolved optical-pump terahertz spectroscopy measurements indicate that photo-generated charge carriers have dc mobilities of up to 205 cm V s in these nanoribbons, exceeding the values previously reported for most other types of nanoribbon or π-conjugated polymer.

Nanomaterials for stroke diagnosis and treatment.

Nanomaterials and nanotechnology innovations possess unique physicochemical properties that present new opportunities in the realm of stroke detection, diagnosis, and treatment. This comprehensive review explores the utilization of nanomaterials in the diagnosis and treatment of strokes, encompassing recent advancements in computed tomography (CT), magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as groundbreaking applications of nanomaterials and bionanomaterials in drug delivery systems and brain tissue repair. Additionally, this review meticulously examines significant challenges such as biocompatibility toxicity and long-term safety, proposing potential strategies to surmount these obstacles.

Assessing clinical medicine students' acceptance of large language model: based on technology acceptance model.

While large language models (LLMs) have demonstrated significant potential in medical education, there is limited understanding of medical students' acceptance of LLMs and the factors influencing their use. This study explores medical students' acceptance of LLMs in learning and examines the factors influencing this acceptance through the lens of the Technology Acceptance Model (TAM). A questionnaire survey conducted among Chinese medical students revealed a high willingness to use LLMs in their studies.

Targeting senescence with radioactive Ra/Ba SAzymes enables senolytics-unlocked One-Two punch strategy to boost anti-tumor immunotherapy.

Senescent cells are characterized by a persistent cessation of their cell cycle, rendering them valuable targets for anti-tumor strategies in cancer treatment. Numerous studies have explored induced senescence as a promising approach in tumor therapy. Nevertheless, these treatments often come with drawbacks, including adverse side effects and weaker senescence-inducing effects.

A clinical study on the effect of axillary approach in the treatment of Ideberg type II scapular glenoid fractures.

Background: Due to its deep position and complex surrounding anatomy, the scapular glenoid fracture was relatively difficult to deal with especially in cases of severe fracture displacement. Improper treatment may lead to failure of internal fixation and poor fracture reduction, severely affecting the function of the shoulder joint. Inferior scapular glenoid fracture was Ideberg type II fracture, and posterior approach was commonly used to deal with inferior scapular glenoid fracture.

Measurement of electron and neutral particle densities using a two-color optical fiber interferometer.

A two-color homodyne Mach-Zehnder optical fiber interferometer is developed for the measurement of electron and neutral particle densities in a high-density capsule θ-pinch device. The interferometer leverages the disparate contributions of distinct particles to the refractive index across two discrete wavelengths of 1310 and 1550 nm and incorporates the contributions of both electron and neutral particle densities to the phase shift in the plasma. The temporal evolutions of line-integrated electron and neutral argon densities are successfully measured by the interferometer.