Infrared spectroscopic study on residual chitosan-based composite seed coating in kaolin.

The decomposition of residual chitosan-based composite seed coating in kaolin under different temperatures and salinities is analyzed with a Fourier transform infrared spectroscopy (FT-IR). The degradation cycle is 28 days. The results show that a residue of the chitosan-based composite seed coating still exists in the kaolin on Day 7.

In situ labeling of pretargeted hyaluronan for PET/MR imaging of CD44+ tumors.

Background: Tumor-specific molecular probe-based imaging strategies have shown great potential for tumor diagnosis. However, the sensitivity and contrast of imaging may interfere with the complex labeling process and degradation of tumor-specific imaging probes. We sought to adapt a pretargeting strategy and an in vivo bioorthogonal reaction to improve hyaluronan (HA)-based tumor multimodal imaging diagnosis.

F-DPA714 PET/MRI as a potential imaging tool for detecting possible antibody-negative autoimmune encephalitis: a prospective study.

Background And Objectives: Conventional magnetic resonance imaging (MRI) used for detecting possible antibody-negative autoimmune encephalitis (AIE) often fails to meet the diagnostic requirements of this disease. Positron emission tomography (PET) with a translocator protein radioligand can help visualize microglia distribution density in inflammation-related diseases, thereby offering potentially incremental value to conventional MRI for the in vivo assessment of possible antibody-negative AIE.

Methods: In this prospective study, 15 participants diagnosed with possible antibody-negative AIE and 10 healthy controls were enrolled (ClinicalTrials.

Construction and Preliminary Evaluation of Two F-Labeled Radiopharmaceuticals for Myocardial Perfusion Imaging.

Aims: PET myocardial perfusion imaging (MPI) is the gold standard for the noninvasive diagnosis of ischemic myocardial. Construction of F-labeled PET MPI probe showed benefits to reduce the imaging cost, and enhance the image quality and patient-friendliness.

Methods: Two F-labeled MPI probes (F-BoMPI) were developed.

In Situ Growth of Columnar PEG on PEDOT and Its Antifouling Properties.

The antifouling properties of conductive polymers have received extensive attention for biosensor and bioelectronic applications. Polyethylene glycol (PEG) is a well-known antifouling material, but the controlled regulation of the surface topography of PEG without a template remains a challenge. Here, we show a columnar structure antifouling conductive polymer brush with enhanced antifouling properties and considerable conductivity.

Sensitive detection of infectious disease utilizing carbon Sphere@FeO micromotor combined with graphene field-effect transistor.

Background: Rapid on-site detection of infectious diseases is considerably essential for preventing and controlling major epidemics and maintaining social and public safety. However, the complexity of the natural environment in which infectious disease pathogens exist severely disrupts the performance of on-site detection, and rapid detection can become meaningless because of the cumbersome sample pretreatment process.

Result: Herein, a new detection platform based on a carbon sphere@FeO micromotor (CS@FeO) in combination with a graphene field-effect transistor (GFET) was designed and used for the on-site detection of SARS-CoV-2 coronavirus pathogens.

On-site detection of infectious disease based on CaCO-based magnetic micromotor integrated with graphene field effect transistor.

A new detection platform based on CaCO-based magnetic micromotor (CaCO@FeO) integrated with graphene field effect transistor (GFET) was construct and used for on-site SARS-CoV-2 coronavirus pathogen detection. The CaCO@FeO micromotor, which was modified with anti-SARS-CoV-2 (labelled antibody, AntiE1), can self-moved in the solution containing hydrochloric acid (HCl) and effective to capture the SARS-CoV-2 coronavirus pathogens. After magnetic field separation, the capture micromotor was detected by GFET, exhibiting a good linear relationship within the range of 1 ag/mL to 100 ng/mL and low detection limit (0.

Microglial Activation Imaging Using F-DPA-714 PET/MRI for Detecting Autoimmune Encephalitis.

Background Translocator protein (TSPO) PET has been used to visualize microglial activation in neuroinflammation and is a potential imaging tool for detecting autoimmune encephalitis (AIE). Purpose To compare the detection rate between TSPO radioligand fluorine 18 (F) DPA-714 PET and conventional MRI and assess the relationship between F-DPA-714 uptake and clinical features in participants with AIE. Materials and Methods Healthy volunteers and patients with AIE were enrolled in this prospective study between December 2021 and April 2023.

Design of a Zn-based nanozyme injectable multifunctional hydrogel with ROS scavenging activity for myocardial infarction therapy.

The existing strategies for myocardial infarction therapy mainly focus on reinstating myocardial blood supply, often disregarding the intrinsic and intricate microenvironment created by elevated levels of reactive oxygen species (ROS) that accompanies myocardial infarction. This microenvironment entails cardiomyocytes apoptosis, substantial vascular cell death, excessive inflammatory infiltration and fibrosis. In such situation, the present study introduces a zinc-based nanozyme injectable multifunctional hydrogel, crafted from ZIF-8, to counteract ROS effects after myocardial infarction.

Value of Ga-FAPI-04 and F-FDG PET/CT in Early Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer.

This prospective study investigated whether PET parameters from F-FDG and Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/CT can predict a pathologic response to neoadjuvant chemotherapy (NAC) early in patients with locally advanced gastric cancer (LAGC). The study included 28 patients with LAGC who underwent F-FDG PET/CT and Ga-FAPI-04 PET/CT at baseline and after 1 cycle of NAC. PET parameters including SUV and tumor-to-background ratio (TBR), as well as the change rate of SUV and TBR, were recorded.

Green One-Step Strategy of Conductive Ink for Active Health Monitoring in Rehabilitation and Early Care.

Conductive ink deposited on flexible substrates through simple methods such as dyeing or printing is one of the most promising approaches for scalable fabrication of wearable electronics. However, excessive chemical additives or a complex preparation process has limited the practical applications of conductive inks. Herein, a highly stable and antibacterial AgNPs/CNT/rGO (SACR) conductive ink with the only assistance of sustainable silk sericin (SS) is developed through a green one-step strategy.

Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice.

Numerous studies have described the notable impact of gut microbiota on the brain in Alzheimer's disease (AD) via the gut - brain axis. However, the molecular mechanisms underlying the involvement of gut microbiota in the development of AD are limited. This study aimed to explore the potential mechanisms of gut microbiota in AD by integrating multi-omics data.

An Intrinsically Magnetic Epicardial Patch for Rapid Vascular Reconstruction and Drug Delivery.

Myocardial infarction (MI) is a major cause of mortality worldwide. The major limitation of regenerative therapy for MI is poor cardiac retention of therapeutics, which results from an inefficient vascular network and poor targeting ability. In this study, a two-layer intrinsically magnetic epicardial patch (MagPatch) prepared by 3D printing with biocompatible materials like poly (glycerol sebacate) (PGS) is designed, poly (ε-caprolactone) (PCL), and NdFeB.

Chitosan modified graphene field-effect transistor biosensor for ultrasensitive procalcitonin detection.

Sepsis is a systemic inflammatory response caused by a bacterial infection that often leading to tissue damage, organ failure and death. Procalcitonin (PCT), as a peptide precursor to hormones, is the main biomarker to identification of the sepsis. In this study, a chitosan modified graphene field transistor (CTS-GFET) was established and first time used for PCT ultra-sensitive detection.

Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.

Purpose: Despite the revealed role of immunological dysfunctions in the development and progression of Alzheimer's disease (AD) through animal and postmortem investigations, direct evidence regarding the impact of genetic factors on microglia response and amyloid-β (Aβ) deposition in AD individuals is lacking. This study aims to elucidate this mechanism by integrating transcriptomics and TSPO, Aβ PET imaging in clinical AD cohort.

Methods: We analyzed 85 patients with PET/MR imaging for microglial activation (TSPO, [F]DPA-714) and Aβ ([F]AV-45) within the prospective Alzheimer's Disease Immunization and Microbiota Initiative Study Cohort (ADIMIC).

Ga-FAPI-04 Positron Emission Tomography Distinguishes Malignancy From F-FDG-Avid Colorectal Lesions.

Purpose: Lesions with a high uptake of F-fluorodeoxyglucose (F-FDG) on positron emission tomography-computed tomography (PET-CT) can be benign and malignant. New radiotracers, such as the gallium 68 (Ga)-labeled fibroblast activation protein inhibitor 4 (FAPI-04), could be used to diagnose colorectal carcinoma. This study aimed to evaluate the efficacy of Ga-FAPI-04 PET in differentiating benign from malignant F-FDG-avid colorectal lesions.

Microstructure, Mechanical and Tribological Properties of High-Entropy Carbide (MoNbTaTiV)C.

High-entropy carbide (NbTaTiV)C (HEC4), (MoNbTaTiV)C (HEC5), and (MoNbTaTiV)C-SiC (HEC5S) multiphase ceramics were prepared by spark plasma sintering (SPS) at 1900 to 2100 °C, using metal carbide and silicon carbide (SiC) as raw materials. Their microstructure, and mechanical and tribological properties were investigated. The results showed that the (MoNbTaTiV)C synthesized at 1900-2100 °C had a face-centered cubic structure and density higher than 95.

Visualization research on ENT1/NIS dual-function gene therapy to reverse drug resistance mediated by MUC1 in GEM-resistant pancreatic cancer.

Purpose: To use bifunctional target genes to increase the intracellular transport of gemcitabine (GEM) to reverse chemotherapy resistance and to simultaneously use reporter gene imaging to localize therapeutic genes. The therapeutic effect was evaluated by [F]FLT PET/CT to visualize the effect of gene therapy.

Methods: A viral gene vector containing the pancreatic cancer-targeting promoter MUC1 for specific transcription of equilibrative nucleoside transporter 1 (ENT1) and NIS (nuclide transport channel) was employed.

NiCoP/g-CN Nanocomposites-Based Electrochemical Immunosensor for Sensitive Detection of Procalcitonin.

Herein, an ultra-sensitive and facile electrochemical biosensor for procalcitonin (PCT) detection was developed based on NiCoP/g-CN nanocomposites. Firstly, NiCoP/g-CN nanocomposites were synthesized using hydrothermal methods and then functionalized on the electrode surface by π-π stacking. Afterward, the monoclonal antibody that can specifically capture the PCT was successfully linked onto the surface of the nanocomposites with a 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS) condensation reaction.

PM2.5 concentration assessment based on geographical and temporal weighted regression model and MCD19A2 from 2015 to 2020 in Xinjiang, China.

PM2.5 is closely linked to both air quality and public health. Many studies have used models combined with remote sensing and auxiliary data to inverse a large range of PM2.

Alterations in histology of the aging salivary gland and correlation with the glandular inflammatory microenvironment.

Aging-related salivary dysfunction typically causes reduced saliva volumes, which leads to debilitating consequences, even affecting patient quality of life. Understanding the respective clinicopathological characteristics and molecular mechanisms underlying salivary gland functioning during aging is vital for therapeutic purposes. Here, we provide a detailed atlas of the salivary gland microenvironment during aging, and we identified several phenotypes characteristic of aging salivary glands, including acini atrophy, increased inflammatory cells, altered immune responses, and accumulation of lysosomes and autophagosomes in aging cells, which may reflect progressive degeneration of salivary gland function.