Publications by authors named "Hai Shan Tian"
Sepsis-induced fulminant hepatitis (FH) is a fatal syndrome that has a worse prognosis in clinical practice. Hence, seeking effective agents for sepsis-induced FH treatment is urgently needed. Fibroblast growth factors (FGFs) are vital for tissue homeostasis and damage repair in various organs including the liver.
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- Delayed wound healing is a key symptom of diabetes mellitus (DM), affecting many patients globally, and the study investigates how high glucose (HG) conditions impact fibroblast cell migration.
- Findings show that while 30 mM HG impedes cell migration, it does not hinder cell proliferation, and bFGF can partially restore normal migration rates by promoting cell movement.
- Mechanistically, the research reveals that HG increases reactive oxygen species (ROS) production and represses JNK phosphorylation, which is crucial for bFGF-regulated migration, demonstrating a link between HG-induced migration delay and bFGF signaling suppression.
Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury.
Can J Physiol Pharmacol
November 2013
Fibroblast growth factor (FGF)-21 is a novel regulator of insulin-independent glucose transport in 3T3-L1 adipocytes and has glucose and triglyceride lowering effects in rodent models of diabetes. In this study, we found that FGF-21 can significantly attenuate ischemia-reperfusion (I/R) induced damage in H9c2 cells (rat heart). However, it is unclear which signal transduction pathway is involved in the cardioprotective effect of FGF-21.
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