Aplastic anemia in a patient with papillary thyroid carcinoma complicated with Hashimoto's thyroiditis: a case report.

Background: It is uncommon to come across instances of aplastic anemia in individuals suffering from papillary thyroid carcinoma complicated by Hashimoto's thyroiditis. Here, a unique case is presented.

Case Presentation: A 23-year-old male was admitted to the hospital for "a lump in his right neck".

Repeated axial compressive performance of GCFST columns: Test investigation and numerical analysis.

Geopolymer concrete (GC) is green and environmentally friendly. In order to comprehensively study the mechanical properties and influence mechanism of geopolymer concrete-filled steel tubular (GCFST) columns under various working conditions, this study takes the strength grade of geopolymer concrete, length-diameter ratio and wall thickness of steel tube as design parameters. Eight GCFST columns are designed and the compressive performances are conducted under repeated axial compression.

Validation Status of Electronic Sphygmomanometers in China: A National Survey.

Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.

Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.

Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.

Background & Aims: Coronavirus disease (COVID-19), caused by severe acquired respiratory syndrome-Coronavirus-2 (SARS-CoV-2), triggered a global pandemic with severe medical and socioeconomic consequences. Although fatality rates are higher among the elderly and those with underlying comorbidities, host factors that promote susceptibility to SARS-CoV-2 infection and severe disease are poorly understood. Although individuals with certain autoimmune/inflammatory disorders show increased susceptibility to viral infections, there is incomplete knowledge of SARS-CoV-2 susceptibility in these diseases.

Attachment Avoidance Mediates the Relationship Between Relatedness Frustration and Social Networking Sites Addiction: Conscientiousness and Neuroticism as Moderators.

Social Networking Sites Addiction (SNSA) has become increasingly prevalent among university students, posing significant challenges to their mental health and academic performance. The psychological mechanisms and personality traits contributing to this addiction are not yet fully understood. This study explored the mediating effect of attachment avoidance (AA) between relatedness frustration (RF) and SNSA, as well as the moderating roles of Conscientiousness and Neuroticism from the Big Five personality traits.

A Herpes Simplex Virus Type-1-Derived Influenza Vaccine Induces Balanced Adaptive Immune Responses and Protects Mice From Lethal Influenza Virus Challenge.

Influenza virus is a major respiratory viral pathogen responsible for the deaths of hundreds of thousands worldwide each year. Current vaccines provide protection primarily by inducing strain-specific antibody responses with the requirement of a match between vaccine strains and circulating strains. It has been suggested that anti-influenza T-cell responses, in addition to antibody responses may provide the broadest protection against different flu strains.

Experimental and numerical investigations on the bond-slip behavior of the interface between geopolymer concrete and steel tube.

This study conducts push-out tests on eight geopolymer concrete filled steel tube column specimens with varying design parameters to evaluate the effects of steel tube wall thickness, concrete strength, and the presence of welded longitudinal ribs on the bond-slip performance at the interface between geopolymer concrete and steel tube. The study analyzes the influence mechanism of chemical bonding force, mechanical bite force, and friction resistance on bond strength and a three-stage bond-slip constitutive relationship is established. The results indicate that steel tube strain increases with height, with significant strain observed at the welding structure and the fixed end of the steel tube.

Research progress and prospects of seismic performance on underground structure embedded in soft soil foundation.

For the complexity and difficulty of seismic research on subway station structure system embedded in soft soil foundation, the seismic research method is quite different from the ground structure. The methods of seismic research on subway station structures in soft soil were summarized, and relevant literature on this field in recent years were sorted out. The advanced progress of theoretical analysis and quasi-static simplification analysis, model test (shaking table test, centrifuge test), numerical simulation (the total stress method, the effective stress method), and dynamic reliability of underground structures were mainly introduced for seismic analysis of subway station embedded in the soft foundation.

Axial compression performances and bearing capacity prediction of self-compacting fly ash concrete filled circle steel tube columns.

To solve the problem of a large amount of fly ash accumulation and study the axial compression and bearing capacity prediction of the self-compacting fly ash concrete filled circle steel tube (SCCFST) columns, eight specimens are designed to explore the impact of concrete strength grade, internal structural measures, and additional parameters. The stress, progression of deformation, and failure mode of each specimen are observed during the loading process. The load-displacement curves, load-strain curves, characteristic load and displacement, ductility, and stiffness degradation are analyzed.

Research on mechanical properties of weak expansive soil under conditions of different confining pressures and moisture contents based on triaxial test.

Objective: To explore the mechanical properties of weak expansive soil under different moisture contents and confining pressures.

Methods: The triaxial remolded soil samples with different moisture contents (14%, 16%, 18%, and 20%) were prepared for the obtained Nanyang weak expansive soil. Four groups of 16 consolidated drained triaxial shear tests with a confining pressure of 50, 100, 200, and 300 kPa were carried out to study the effects of confining pressure and water content on the deviatoric stress and pore pressure of weak expansive soil with strain.

Mechanisms of minor pole-mediated spindle bipolarization in human oocytes.

Spindle bipolarization, the process of a microtubule mass transforming into a bipolar spindle, is a prerequisite for accurate chromosome segregation. In contrast to mitotic cells, the process and mechanism of spindle bipolarization in human oocytes remains unclear. Using high-resolution imaging in more than 1800 human oocytes, we revealed a typical state of multipolar intermediates that form during spindle bipolarization and elucidated the mechanism underlying this process.

Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells.

Global control of infectious diseases depends on the continuous development and deployment of diverse vaccination strategies. Currently available live-attenuated and killed virus vaccines typically take a week or longer to activate specific protection by the adaptive immunity. The mosquito-transmitted Nodamura virus (NoV) is attenuated in mice by mutations that prevent expression of the B2 viral suppressor of RNA interference (VSR) and consequently, drastically enhance in vivo production of the virus-targeting small-interfering RNAs.

Erratum: HOXC10 promotes carboplatin resistance of ovarian cancer by regulating ABCC3.

[This corrects the article on p. 4602 in vol. 12, PMID: 36381312.

Harnessing preexisting influenza virus-specific immunity increases antibody responses against SARS-CoV-2.

In pandemic scenarios involving novel human pathogenic viruses, it is highly desirable that vaccines induce strong neutralizing antibodies as quickly as possible. However, current vaccine strategies require multiple immunization doses to produce high titers of neutralizing antibodies and are poorly protective after a single vaccination. We therefore wished to design a vaccine candidate that would induce increased protective immune responses following the first vaccine dose.

Molecular Dynamics Simulation of Silane Inserted CSH Nanostructure.

Herein, the toughening mechanism and effects of 3-(aminopropyl)triethoxysilane (3-APTES) intercalation in calcium-silicate-hydrate (CSH) structures were investigated through molecular dynamics simulations. CSH established a model using 11 Å-tobermorite to simulate the tensile properties, toughness, adsorption energy, average orientation displacement and radial distribution function of 3-APTES intercalation at different Ca/Si ratios under conditions of a CVFF force field, an NVT system, and 298 K temperature. Simulation results demonstrate that 3-APTES alters the fracture process of CSH and effectively enhances its tensile properties and toughness.

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.

Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), rely on their non-structural protein 5 (NS5) for both replication of viral genome and suppression of host IFN signaling. DENV and ZIKV NS5s were shown to facilitate proteosome-mediated protein degradation of human STAT2 (hSTAT2). However, how flavivirus NS5s have evolved for species-specific IFN-suppression remains unclear.

Thyrotropin induces atherosclerosis by upregulating large conductance Ca-activated K channel subunits.

Hypothyroidism is associated with elevated levels of serum thyrotropin (TSH), which have been shown to promote abnormal proliferation of vascular smooth muscle cells and contribute to the development of atherosclerosis. However, the specific mechanisms underlying the TSH-induced abnormal proliferation of vascular smooth muscle cells remain unclear. The objective of this study was to investigate the role of TSH in the progression of atherosclerosis.

SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice.

In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients.

Papillary thyroid carcinoma with clear cell renal cell carcinoma metastasized to the thyroid gland: A case report.

Metastasis of clear cell renal cell carcinoma (ccRCC) to the thyroid gland is rare, and simultaneous occurrence of ccRCC and papillary thyroid carcinoma (PTC) is even rarer. Due to the occult nature of the disease, the clinical diagnosis is difficult. In the case of multiple tumors, the possibility of thyroid metastasis should not be ignored during the clinical diagnosis and treatment of PTC.

Study on seismic vulnerability analysis of the interaction system between saturated soft soil and subway station structures.

The seismic vulnerability of interaction system of saturated soft soil and subway station structures was explored in this paper. The coupled nonlinear numerical models of interaction system were established using the u-p formulation of Biot's theory to describe the saturated two-phase media. A refined finite element model of interaction system was developed to study its nonlinear seismic responses and seismic hazard mechanism.

Modeling the effects of cigarette smoke extract on influenza B virus infections in mice.

Influenza B virus (IBV) is a major respiratory viral pathogen. Due to a lack of pandemic potential for IBV, there is a lag in research on IBV pathology and immunological responses compared to IAV. Therefore, the impact of various lifestyle and environmental factors on IBV infections, such as cigarette smoking (CS), remains elusive.

3D Printing a Low-Cost Miniature Accommodating Optical Microscope.

This decade has witnessed the tremendous progress in miniaturizing optical imaging systems. Despite the advancements in 3D printing optical lenses at increasingly smaller dimensions, challenges remain in precisely manufacturing the dimensionally compatible optomechanical components and assembling them into a functional imaging system. To tackle this issue, the use of 3D printing to enable digitalized optomechanical component manufacturing, part-count-reduction design, and the inclusion of passive alignment features is reported here, all for the ease of system assembly.