[The role of clock gene BMAL1 in exercise-induced skeletal muscle injury recovery].

To investigate the role of clock gene BMAL1 in exercise-induced skeletal muscle injury recovery. Two hundred and eight 8-week-old SD rats were randomly divided into the control group (Group C, =104) and the exercise group (Group E, =104). Group E performed a 90-minute downhill run on the treadmill.

Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions.

The neurotrophin brain-derived neurotrophic factor (BDNF), which acts as a transducer, is responsible for improving cerebral stroke, neuropathic pain, and depression. Exercise can alter extracellular nucleotide levels and purinergic receptors in central nervous system (CNS) structures. This inevitably activates or inhibits the expression of BDNF via purinergic receptors, particularly the P2X receptor (P2XR), to alleviate pathological progression.

[Effects of acupuncture on endoplasmic reticulum pathway in exercise-induced skeletal muscle damage in rats and its mechanism].

To observe the effects of acupuncture on the endoplasmic reticulum (ER) functional enzymes sarcoplasmic reticulum Ca-ATPase (SERCA), protein disulfide isomerase (PDI), glucose-regulated protein 78(GRP78) and PERK pathways in rats with exercise-induced skeletal muscle damage, and to explore the mechanisms of acupuncture in preventing and treating exercise-induced skeletal muscle damage. Eight-week-old male SD rats were randomly divided into control group (group C, =6), exercise group (group E, =30), acupuncture group (group A, =30) and exercise acupuncture group (group EA, =30). Among them, the E and EA group were established an exercise-induced skeletal muscle damage model by a single eccentric exercise, and acupuncture intervention was applied 0.