From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.

The treatment and repair of bone tissue damage and loss due to infection, tumours, and trauma are major challenges in clinical practice. Artificial bone scaffolds offer a safer, simpler, and more feasible alternative to bone transplantation, serving to fill bone defects and promote bone tissue regeneration. Ideally, these scaffolds should possess osteoconductive, osteoinductive, and osseointegrative properties.

Genomic prediction of yield-related traits and genome-based establishment of heterotic pattern in maize hybrid breeding of Southwest China.

When genomic prediction is implemented in breeding maize ( L.), it can accelerate the breeding process and reduce cost to a large extent. In this study, 11 yield-related traits of maize were used to evaluate four genomic prediction methods including rrBLUP, HEBLP|A, RF, and LightGBM.

Single-frequency orbital angular momentum switchable modes from a microchip laser.

We demonstrate the direct generation of single-frequency switchable orbital angular momentum (OAM) modes in a 1 µm wavelength range using a Nd:YVO microchip laser. The 808 nm laser diode pump beam is shaped into annular through an axicon associated with a lens. By adjusting the diameter and power of the annular pump beam, various OAM modes with different mode volumes can oscillate inside the Nd:YVO microchip.

Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor.

Using an established human primary cell culture model, we previously demonstrated that the promyelocytic leukemia zinc finger (PLZF) transcription factor is a direct target of the progesterone receptor (PGR) and is essential for progestin-dependent decidualization of human endometrial stromal cells (HESCs). These in vitro findings were supported by immunohistochemical analysis of human endometrial tissue biopsies, which showed that the strongest immunoreactivity for endometrial PLZF is detected during the progesterone (P4)-dominant secretory phase of the menstrual cycle. While these human studies provided critical clinical support for the important role of PLZF in P4-dependent HESC decidualization, functional validation in vivo was not possible due to the absence of suitable animal models.

From transients to permanent residents: the existence of obligate aerobic microorganisms in the goat rumen.

The rumen serves as a complex ecosystem, harboring diverse microbial communities that play crucial ecological roles. Because previous studies have predominantly focused on anaerobic microorganisms, limited attention has been given to aerobic microorganisms in the goat rumen. This study aims to explore the diversity of aerobic microorganisms in the rumen and understand their niche and ecological roles.

Power amplification for 1.6 µm high-order vortex modes.

1.6 µm high-order vortex modes carrying orbital angular momentums (OAMs) play significant roles in long-range Doppler lidars and other remote sensing. Amplification of 1.

Genome-Wide Identification and Characterization of the Family from and Its Role in Long-Distance Signaling.

The protein phosphatase 2C (PP2C) constitutes a large gene family that plays crucial roles in regulating stress responses and plant development. A recent study has shown the involvement of an family member in long-distance nitrogen signaling in Arabidopsis. However, it remains unclear whether maize adopts a similar mechanism.

Effects of Tea Polyphenols and Theaflavins on Three Oral Cariogenic Bacteria.

In order to investigate the antibacterial mechanism of tea polyphenols and theaflavins against oral cariogenic bacteria, the pH value of the culture medium, the number of bacteria adhering to the smooth glass tube wall, and the electrical conductivity value within 10 h were measured, respectively. The effects of four concentrations of tea polyphenols and theaflavins below the MIC value were studied on acid production, adhesion, and electrical conductivity of oral cariogenic bacteria. The live/dead staining method was used to observe the effects of four concentrations of tea polyphenols and theaflavins below the MIC value on the biofilm formation of oral cariogenic bacteria under a laser scanning confocal microscope.

Atypical Sweet syndrome: skin sinus tracts in an acutely febrile patient after lymphoma treatment: a case report.

Sweet syndrome (SS) is an uncommon inflammatory disease that involves painful skin, edematous, red papules, plaques, or nodules often accompanied by fever and leukocytosis. SS has three subtypes, including classical, malignant-tumor associated, and drug-induced SS (DISS). Patients with DISS have clear histories of recent drug exposure.

Comparison of the Ways in Which Nitidine Chloride and Bufalin Induce Programmed Cell Death in Hematological Tumor Cells.

The objective of this work to study the programmed cell death (PCD) in hematological tumor cells induced by nitidine chloride (NC) and bufalin (BF). Hematological tumor cells were exposed to various doses of NC and BF to measure the level of growth inhibition. While inverted microscope is used to observe cell morphology, western blot technique is used to detect apoptosis-related protein expression levels.

369Fabrication of 3D gel-printed β-tricalcium phosphate/titanium dioxide porous scaffolds for cancellous bone tissue engineering.

Human bone is composed of cortical bone and cancellous bone. The interior portion of natural bone is cancellous with a porosity of 50%-90%, but the outer layer is made of dense cortical bone, of which porosity was not higher than 10%. Porous ceramics were expected to be research hotspot in bone tissue engineering by virtue of their similarity to the mineral constituent and physiological structure of human bone.

Regulating the thickness of the carbon coating layer in iron/carbon heterostructures to enhance the catalytic performance for oxygen evolution reaction.

The exploration of high-performance electrocatalysts for the oxygen evolution reaction (OER) is crucial and urgent for the fast development of green and renewable hydrogen energy. Herein, an ultra-fast and energy-efficient preparation strategy (microwave-assisted rapid in-situ pyrolysis of organometallic compounds induced by carbon nanotube (CNT)) is developed to obtain iron/carbon (Fe/C) heterogeneous materials (Fe/FeC particles wrapped by carbon coating layer). The thickness of the carbon coating layer can be adjusted by changing the content and form of carbon in the metal sources during the fast preparation process.

A Novel Method for Detecting Fe at a Micromolar Concentration Based on Multiple Self-Mixing Interference Using a Fiber Laser.

The concentration of an electrolyte is an optical characteristic of drinking water. We propose a method based on the multiple self-mixing interference with absorption for detecting the Fe indicator as the electrolyte sample at a micromolar concentration. The theoretical expressions were derived based on the lasing amplitude condition in the presence of the reflected lights considering the concentration of the Fe indicator via the absorption decay according to Beer's law.

An efficient genomic prediction method without the direct inverse of the genomic relationship matrix.

GBLUP, the most widely used genomic prediction (GP) method, consumes large and increasing amounts of computational resources as the training population size increases due to the inverse of the genomic relationship matrix (GRM). Therefore, in this study, we developed a new genomic prediction method (RHEPCG) that avoids the direct inverse of the GRM by combining randomized Haseman-Elston (HE) regression (RHE-reg) and a preconditioned conjugate gradient (PCG). The simulation results demonstrate that RHEPCG, in most cases, not only achieves similar predictive accuracy with GBLUP but also significantly reduces computational time.

The NLR family pyrin domain containing 3 inflammasome in the mechanism of electroacupuncture: Current status and future perspectives.

Electroacupuncture, which is the most widely used alternative medicine treatment, has been gradually recognized for its effectiveness; however, its mechanism of action is not fully understood. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is a thoroughly studied inflammasome that is closely associated with Alzheimer's disease, spinal cord injury, and other diseases and plays an important role in the diagnosis and treatment of human immune system diseases. In recent years, some scholars have found that the NLRP3 inflammasome is a part of the mechanism of action of electroacupuncture, which has attracted further attention.

Multiplexed vortex state array toward high-dimensional data multicasting.

Optical vortex array has drawn widespread attention since the boom of special applications such as molecular selecting and optical communication. Here, we propose an integrated phase-only scheme to generate multiple multiplexed vortex beams simultaneously, constituting a multiplexed vortex state array, where the spatial position, as well as the corresponding orbital angular momentum (OAM) spectrum, can be manipulated flexibly as desired. Proof-of-concept experiments are carried out and show a few different multiplexed vortex state arrays that fit well with the simulation.

Public Opinions on COVID-19 Vaccines-A Spatiotemporal Perspective on Races and Topics Using a Bayesian-Based Method.

The COVID-19 pandemic has been sweeping across the United States of America since early 2020. The whole world was waiting for vaccination to end this pandemic. Since the approval of the first vaccine by the U.

Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats.

Ethnopharmacological Relevance: The plant Erigeron breviscapus (Vant.) Hand.-Mazz.

Regulatory Effects of LncRNA SNHG4 on miR-25/FBXW7 Axis in Papillary Thyroid Cancer Cells.

We analyzed the interaction between miR-25 and SNHG4 in papillary thyroid cancer (PTC). LncRNA SNHG4 was identified as an oncogene in osteosarcoma. We analyzed The Cancer Genome Atlas (TCGA) data and found that SNHG4 was downregulated in papillary thyroid cancer (PTC).

Knockdown of KRAB domain-associated protein 1 suppresses the proliferation, migration and invasion of thyroid cancer cells by regulating P68/DEAD box protein 5.

KRAB domain-associated protein 1 (KAP-1) has been reported to be an oncogene in diverse tumors. KAP-1 was found to have abundant existence in malignant thyroid tissues, but its role in thyroid cancer hasn't been elucidated clearly. This study was carried out to explore the role of KAP-1 in thyroid cancer, and to clarify its molecular mechanism.

Recent Advances in the Analysis of Cold Tolerance in Maize.

Maize ( L.) is an annual grass that originated in tropical and subtropical regions of the New World. Maize is highly sensitive to cold stress during seed gemination and the seedling phase, which can lead to reductions in plant vigor and grain production.

Adjusted EfficientNet for the diagnostic of orbital angular momentum spectrum.

Orbital angular momentum (OAM) is one of multiple dimensions of beams. A beam can carry multiple OAM components, and their intensity weights form the OAM spectrum. The OAM spectrum determines complex amplitude distributions of a beam and features unique characteristics.

Asymmetric determinants of CO emissions in China: do government size and economic size matter?

CO emission reduction is a long-term strategy for China to promote its government and economic size. However, this study examines the asymmetric impact of government size and economic size on CO emissions in China. The study embraces the nonlinear ARDL framework of time series data analysis as proposed by Shin et al.

Asymmetric macroeconomic determinants of energy intensity in China: does economic development matter?

Previously, several studies have tried to analyze the various determinants of energy intensity for different countries and regions. However, none of the studies have focused on the asymmetric determinants of energy intensity in the context of China. Therefore, the primary aim of this study is to investigate the asymmetric determinants of energy intensity in China.