Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis.

Mitochondrial damage will hinder the energy production of cells and produce excessive ROS (reactive oxygen species), resulting in cell death through autophagy or apoptosis. In this paper, four cyclometalated iridium(III) complexes (Ir1: [Ir(piq)L]PF; Ir2: [Ir(bzq)L]PF; Ir3: [Ir(dfppy)L]PF; Ir4: [Ir(thpy)L]PF; piq = 1-phenylisoquinoline; bzq = benzo[h]quinoline; dfppy = 2-(2,4-difluorophenyl)pyridine;thpy = 2-(2-thienyl)pyridine; L = 1,10-phenanthroline-5-amine) were synthesized and characterized. Cytotoxicity tests show that these complexes have excellent cytotoxicity to cancer cells, and mechanism studies indicatethat these complexes can specifically target mitochondria.

Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity.

As the "powerhouse" of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complexes bearing guanidinium derivatives have been synthesized and characterized. All of these complexes exhibit moderate anticancer activity in HepG2, HeLa, MCF-7, and A549 cancer cells.

[Spatial-temporal process and characteristics of vegetation recovery after Wenchuan earthquake: A case study in Longxi River basin of Dujiangyan, China.].

Quantitative evaluation on the vegetation recovery after the earthquake is of great scienti-fic significance for local ecological system rebuilding and regional social-economic sustainable deve-lopment. By taking the Longxi River Basin in Dujiangyan of Sichuan Province as an example, and employing the MODIS-NDVI time-series data, this paper illustrated the dynamic changes of the ve-getation cover rates in Longxi River basin before and after the 5.12 Wenchuan Earthquake by using Landsat data, and then time-space characters of the recovery rates of the damaged vegetation was quantified structurally by referring the factors of river-system and terrain.