Artificial intelligence-assisted point-of-care devices for lung cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide, primarily due to late-stage detection, which limits treatment options. Early detection and screening can increase survival rates, but traditional medical imaging methods are costly and inconvenient. Point-of-care biosensors present a promising alternative, being user-friendly, less labor-intensive, and minimally invasive.

Pyridyne radical cations produced by photodissociation of Mg*+ (multifluoro-pyridine) complexes: a combined experimental and theoretical study.

Gas phase complexes Mg*+ (2,6-difluoropyridine) (1) and Mg*+ (pentafluoropyridine) (2) have been subjected to photodissociation in the spectral range of approximately 230-440 nm. Except for the evaporative photofragment Mg*+ , the primary photoproduct for is C(5)H(3)N*(+), which is associated with the rupture of two C-F bonds by the photoexcited Mg*+ , forming very stable MgF(2). In contrast, the direct loss of MgF(+) is more favorable for due to fluorine substitution.

[The methylation pattern of LRP15 gene in acute leukemia].

Objective: To investigate the methylation status of LRP15 gene in acute leukemia (AL) and its role in tumorigenesis.

Methods: 73 cases of AL and 9 healthy subjects as well as COS7, K562 and HL60 cell lines were studied with methylation specific PCR (MSP).

Results: LRP15 was not detected in all the samples.

Fluorine-substitution induced switching of dissociation patterns of C6H4*+ produced by photoelimination of MgF2 from the complexes of mg*+ (multifluorobenzene).

Complexes of fluorinated benzenes (o-C6H4-nF2+n) and Mg*+ are subjected to ultraviolet photodissociation (260-340 nm), producing efficiently benzyne radical cations (C6H4-nFn*+) besides Mg*+ and MgF+. We show that the consecutive dissociation of C6H4-nFn*+ follows the [C4(+) + C2] pattern exclusively for n < or = 2 after the parent complexes absorb one or two photons. However, the dissociation pattern is switched to [C5(+) + C1] and [C1 + C5] for n > or = 3.

Unusual chemistry of the complex Mg*+(2-fluoropyridine) activated by the photoexcitation of Mg*+.

The photochemistry of a gas-phase complex, Mg*(+)(2-fluoropyridine), has been studied in the spectral range of approximately 230-440 nm with a molecular beam coupled with a time-of-flight mass spectrometer. Surprisingly rich chemistry has been observed. Aside from the evaporative photofragment, Mg*(+), an abundant photoproduct, C(4)H(4)*(+), is observed after the electronic excitation of Mg(+).

[Comparison of curative effect of autologous peripheral blood stem cell transplantation versus bone marrow transplantation for acute leukemia].

To compare the clinical outcome of autologous peripheral blood stem cell transplantation (APBSCT) and autologous bone marrow transplantation (ABMT) in treatment of patients with acute leukemia in first remission, 41 patients received APBSCT, 17 patients received unpurged ABMT and 30 patients received purged ABMT. The results showed that hematopoietic recovery was significantly earlier after APBSCT than that after purged or unpurged ABMT. The 3-year disease-free survival (DFS), relapse rate (RR) and transplant-related mortality (TRM) for all patients of 3 groups were 51.

Formation and decomposition of distonic o-, m-, and p-benzyne radical cations from photolysis of Mg(+)(o-, m-, p-C(6)H(4)F(2)).

Distonic o-, m-, and p-benzyne radical cations (1-3) have been generated by a novel photolysis reaction of mass-selected Mg(+)-difluorobenzene complexes. The energy required for the formation of these radical cations is within 2.2 eV.