Publications by authors named "Hai Bin Zhu"
Article Synopsis
- - The study analyzed how different types of nodule-pleural relationships (like those with pleural tail signs) affect the risk of pneumothorax during CT-guided biopsies in lung nodules.
- - Results showed that nodules in contact with the pleura had a lower risk of pneumothorax compared to those with pleural tail signs or being pleural unrelated, highlighting the importance of nodule positioning.
- - Key factors increasing the risk of pneumothorax included crossing pleural tail signs, longer biopsy time, deeper needle insertion, and nodules located in the middle or lower lobes.
Objectives: To study the regularity of central response to thermal needle stimulation of "Zusanli" (ST36) at different temperature, and to analyze the temperature difference of central responses.
Methods: Six male C57BL/6j adult mice were used in the present study. For observing activities of neurons in the hindlimb region of left primary somatosensory cortex (S1HL, A/P=0.
Article Synopsis
- Around 10%-31% of patients with colorectal liver metastases (CRLM) also have hepatic lymph node metastases (LNM), which often indicates a worse prognosis and complicates surgical options due to a lack of effective preoperative assessment methods.
- This study aimed to evaluate the effectiveness of different diffusion-weighted imaging (DWI) models in identifying benign versus malignant hepatic lymph nodes in CRLM patients who received neoadjuvant chemotherapy.
- Results showed that a nomogram based on the DDC value and the size of lymph nodes post-treatment could reliably predict lymph node status, outperforming other methods in distinguishing between benign and malignant cases.
Background: Few studies about the association between computed tomography (CT) perfusion imaging parameters and invasiveness in lung adenocarcinoma (LUAD) have been conducted using low dose spectral CT perfusion imaging. The purpose of this study was to investigate application of spectral revolution CT low-dose perfusion imaging in the differential diagnosis of different pathological subtypes of LUAD.
Methods: This was a cross-sectional study based on historical data from January 2018 to May 2019 in Peking University Cancer Hospital & Institute.
Background: Significant correlation between lymphatic, microvascular, and perineural invasion (LMPI) and the prognosis of pancreatic neuroendocrine tumors (PENTs) was confirmed by previous studies. There was no previous study reported the relationship between magnetic resonance imaging (MRI) parameters and LMPI.
Aim: To determine the feasibility of using preoperative MRI of the pancreas to predict LMPI in patients with non-functioning PENTs (NFPNETs).
Article Synopsis
- Methyl formate (MF) is a key chemical compound used in various applications and its electrosynthesis is gaining popularity due to its environmental benefits.
- This study introduces a new electrosynthesis method for MF using a halide-containing methanol solution, revealing a specific reaction mechanism involving aldehyde and methoxy bromide.
- The process boasts high efficiency, consistently achieving around 60% faradaic efficiency for MF production and 100% efficiency for hydrogen gas generation, making it superior to other synthesis methods.
Article Synopsis
- The electrochemical reduction of carbon dioxide is crucial for reducing greenhouse gas emissions, but improvements in efficiency are needed, especially in the anodic oxygen evolution reaction.
- A new bifunctional catalyst, CuS/TiO, has been developed that efficiently conducts both methanol oxidation and carbon dioxide reduction, enhancing the production of formate.
- This catalyst achieved a remarkable total Faradaic efficiency of approximately 170%, with 70% from cathodic carbon dioxide reduction and nearly 100% from anodic methanol oxidation.
Objective: To investigate the effects of mild moxibustion at 45°C on the chronic inflammatory response of the abdominal aorta in rats with hyperlipidemia and the effects of different moxibustion durations.
Methods: Thirty-six SD rats were randomly divided into the following groups： blank control group (2 weeks), model group (2 weeks), moxibustion group (2 weeks), blank group (4 weeks), model group (4 weeks), and moxibustion group (4 weeks). A model of hyperlipidemia with chronic inflammation was established through high-fat diet feeding for 8 weeks.
Objectives: To explore the potential of radiomics features to predict the histologic grade of nonfunctioning pancreatic neuroendocrine tumor (NF-PNET) patients using non-contrast sequence based on MRI.
Methods: Two hundred twenty-eight patients with NF-PNETs undergoing MRI at 5 centers were retrospectively analyzed. Data from center 1 (n = 115) constituted the training cohort, and data from centers 2-5 (n = 113) constituted the testing cohort.
Article Synopsis
- This study examined how common carbapenem-resistant Enterobacterales (CRE) infections and colonizations are in intensive care unit (ICU) patients and what factors contribute to their presence at admission and during the hospital stay.
- Conducted across 24 ICUs in Anhui, China, the research involved screening patients and applying statistical analysis to identify risk factors linked to CRE colonization/infection.
- Findings revealed that 5.9% of patients had CRE at admission and 8.5% acquired it during their ICU stay, with several identified risk factors including prior hospital transfers, recent antibiotic exposure, and prolonged ICU stays.
Article Synopsis
- * A total of 215 patients were evaluated, revealing that 87.9% experienced non-significant pain during the procedure, with an average pain score of 2 out of 10.
- * Significant pain was linked to larger lesions (≥ 34 mm), a specific needle angle (≥ 77°), and longer procedure times (≥ 26.5 min).
Background: This study sought to investigate the applicability of different ultrasound (US) thyroid risk stratification systems in diagnosing medullary thyroid carcinoma (MTC) and determining the need for biopsy.
Methods: In total, 34 MTC nodules, 54 papillary thyroid carcinoma (PTC) nodules, and 62 benign thyroid nodules were examined in this study. All the diagnoses were histopathologically confirmed postoperatively.
Objective: To explore the antioxidant effect of moxibustion on vascular endothelial function and the under-lying mechanism.
Methods: Forty male SD rats were randomly divided into blank, model, moxibustion and endothelial nitric oxide synthase (eNOS) inhibitor groups, with 10 rats in each group. Hyperlipidemia rat model was established by high fat diet for 8 weeks.
Background: Patients with colorectal liver metastases (CRLM) combined with hepatic lymph node (HLN) metastases have a poor prognosis. In this study, we developed and validated a model using clinical and magnetic resonance imaging (MRI) parameters to predict HLN status before surgery.
Methods: A total of 104 CRLM patients undergoing hepatic lymphonodectomy with pathologically confirmed HLN status after preoperative chemotherapy were enrolled in this study.
Zn(II)-MOF derived N-doped carbons achieve marked ORR activity in alkaline and acidic media.
Chem Commun (Camb)
January 2023
Article Synopsis
- A new, efficient metal-free N-doped carbon electrocatalyst was created using a one-pot pyrolysis method from a lone Zn(II)-MOF with a combination of azolate and terephthalate ligands.
- The electrocatalyst showed impressive performance with an onset potential of 0.88 V (RHE) in a 0.1 M KOH solution and 0.79 V (RHE) in a 0.5 M HSO solution.
- This work highlights the catalyst as one of the top-performing metal-free options for the acidic oxygen reduction reaction (ORR).
Mn-N-C materials have received increasing interest in recent years because of their low Fenton reactivity and ORR activity comparable to those of their Fe-N-C and Co-N-C counterparts. In this contribution, an atomically dispersed Mn-N-C electrocatalyst with a prominent oxygen reduction performance was constructed by employing a cationic Cd-MOF as a precursor that can facilely and accurately introduce MnO anions through anion exchange. The best-performing Mn-N-C catalyst displays a 0.
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- The study aimed to enhance the prediction of lymph node metastasis (LNM) in nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) using MRI features.
- Researchers analyzed data from 187 NF-PNET patients, establishing a multivariate logistic regression model to identify key MRI predictors of LNM.
- The findings showed that specific MRI characteristics, like the primary tumor's shape and the size of the largest lymph node, significantly predicted LNM, potentially aiding in surgical planning.
Purpose: Current low anterior resection syndrome (LARS) score is lagging behind and only based on clinical symptoms patient described. Preoperative imaging indicators which can be used to predict LARS is unknown. We proposed preoperative MRI parameters for identifying major LARS.
View Article and Find Full Text PDFBackground: The prognosis of patients with liver metastases during or early after adjuvant chemotherapy for colorectal cancer (CRC) is significantly worse. This study aimed to explore the efficacy of perioperative second-line chemotherapy in prolonging survival in those patients.
Methods: Patients who underwent liver resection, with resectable liver metastases that occurred within 12 months after the last cycle of adjuvant chemotherapy for CRC, from January 2006 to December 2019, were included.
Article Synopsis
- RECIST criteria, commonly used to evaluate treatment effectiveness in colorectal liver metastases (CRLM), have shown limitations in accuracy, prompting this study to compare them with functional MRI results.
- The study involved 137 CRLM patients undergoing neoadjuvant chemotherapy, divided into groups based on whether they received bevacizumab, measuring apparent diffusion coefficient (ADC) values to gauge overall and relapse-free survival.
- Findings indicated that post-treatment ADC values were significantly tied to better overall survival and relapse-free survival in the bevacizumab group, highlighting the superior predictive capability of ADC measurements over RECIST criteria.
Background: The cT3 substage criteria based on extramural depth of tumor invasion in rectal cancer have several limitations.
Objective: This study proposed that the distance between the deepest tumor invasion and mesorectal fascia on pretherapy MRI can distinguish the prognosis of patients with cT3 rectal cancer.
Design: This is a cohort study.
Accurate evaluation of tumor response to preoperative chemotherapy is crucial for assigning appropriate patients with colorectal liver metastases (CRLM) to surgery or conservative therapy. However, there is no well-recognized method for predicting pathological response before surgery. Our study constructed and validated a deep learning algorithm using prechemotherapy and postchemotherapy magnetic resonance imaging (MRI) to predict pathological response in CRLM.
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- Liver kinase B1 (LKB1) is a key enzyme linked to Peutz-Jeghers syndrome, which typically plays a role in protecting cancer cells from metabolic stress while promoting their survival and spread.
- This review highlights how LKB1's role in cancer contradicts the idea of it being a tumor suppressor, as its deletion leads to increased stress and genomic instability in cancer cells.
- The authors explore how mutated LKB1 works with other genes to help cancer cells adapt to harsh metabolic conditions, ultimately leading to more aggressive cancer behavior.
Injectable pegylated niclosamide (polyethylene glycol-modified niclosamide) for cancer therapy.
J Biomed Mater Res A
January 2020
Article Synopsis
- * The study aims to create a more effective delivery method by synthesizing pegylated niclosamide (mPEG5000-Nic), which significantly enhances solubility and decreases toxicity while showing promise against colon cancer cells both in lab settings and in animal models.
- * The results indicate that mPEG5000-Nic successfully inhibits tumor growth in a mouse model without causing noticeable adverse effects, suggesting it could be a viable option for cancer treatment compared to traditional therapies like 5
A highly active and stable Fe3C-containing Fe/N/C catalyst, derived from a cationic Cd(ii)-based metal-organic framework involving accurate control over Fe-doping via anion-exchange with potassium ferricyanide, shows superior oxygen reduction performance over the benchmark Pt/C catalyst in an alkaline electrolyte.
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