Nutritional Gender-Specific Differences in Head and Neck Cancer Patients Treated with (Chemo)Radiotherapy: Results from a Prospective Trial.

: This analysis aims to evaluate gender-specific differences in nutritional status, body weight changes, and their impact on overall survival (OS) in head and neck cancer (HNC) patients undergoing (chemo)radiotherapy (CRT). : Between 2018 and 2020, 61 HNC (17 female and 44 male) patients were prospectively recruited to receive curative (chemo)radiotherapy. Nutritional assessments included dietary questionnaire screenings and records, anthropometric methods (body mass index, BMI, body composition via bioelectrical impedance analysis (BIA)), and the determination of biomarkers like albumin and CRP.

How Do Enriched Speech Acoustics Support Language Acquisition in Children With Hearing Loss? A Narrative Review.

Language outcomes of children with hearing loss remain heterogeneous despite recent advances in treatment and intervention. Consonants with high frequency, in particular, continue to pose challenges to affected children's speech perception and production. In this review, the authors evaluate findings of how enriched child-directed speech and song might function as a form of early family-centered intervention to remedy the effects of hearing loss on consonant acquisition already during infancy.

Efficacy of the "7mind"-app as intervention to prevent postpartum depression in a low-risk sample group.

Introduction: Postpartum depression (PPD) is a severe complication in the postpartum period and equals a major depression occurring in the first weeks after delivery. During the COVID-19 pandemic, an increased incidence of PPD was observed. For this reason, we conducted an intervention study to test the effectiveness of the "7mind"-app, an app-based mindfulness training program, in the prevention of PPD.

Salivary Gland Volume Predicts Malnutrition in Irradiated Head and Neck Cancer Patients: A Prospective Analysis.

Background/aim: Xerostomia following (chemo-) radiotherapy (CRT) is common in head and neck (HNC) patients. This prospective study focused on investigating the link between salivary gland function and the onset of malnutrition in HNC patients.

Patients And Methods: Between 2018 and 2020, 61 HNC patients scheduled for curative CRT were prospectively recruited.

Simulating clinical features on chest radiographs for medical image exploration and CNN explainability using a style-based generative adversarial autoencoder.

Explainability of convolutional neural networks (CNNs) is integral for their adoption into radiological practice. Commonly used attribution methods localize image areas important for CNN prediction but do not characterize relevant imaging features underlying these areas, acting as a barrier to the adoption of CNNs for clinical use. We therefore propose Semantic Exploration and Explainability using a Style-based Generative Adversarial Autoencoder Network (SEE-GAAN), an explainability framework that uses latent space manipulation to generate a sequence of synthetic images that semantically visualizes how clinical and CNN features manifest within medical images.

Unsustainable: Why I Left Primary Care.

A physician reflects on what drove her out of primary care, and how it might be fixed.

Peripheral Non-Contrast MR Angiography Using FBI: Scan Time and T2 Blurring Reduction with 2D Parallel Imaging.

Non-contrast magnetic resonance angiography (NC-MRA), including fresh blood imaging (FBI), is a suitable choice for evaluating patients with peripheral artery disease (PAD). We evaluated standard FBI (sFBI) and centric ky-kz FBI (cFBI) acquisitions, using 1D and 2D parallel imaging factors (PIFs) to assess the trade-off between scan time and image quality due to blurring. The bilateral legs of four volunteers (mean age 33 years, two females) were imaged in the coronal plane using a body array coil with a posterior spine coil.

CCL22 as an independent prognostic factor in endometrial cancer patients.

Objectives: The chemokine CCL22 is recognized for recruiting immunosuppressive regulatory T-cells (Treg) that contribute to disease progression in various tumor entities helping them to evade the host immune response. Our study aims to identify the expressing cell types and to evaluate the prognostic significance of CCL22 secretion and its association with Treg invasion in endometrial cancer (EC), an immunogenic cancer.

Methods: Specimens from 275 patients with EC and 28 healthy controls were screened immunohistochemically for CCL22.

Clinical, Genetic, and Histopathological Characteristics of CRX-associated Retinal Dystrophies.

Purpose: To describe phenotypic, genotypic, and histopathological features of inherited retinal dystrophies associated with the CRX gene (CRX-RDs).

Design: Retrospective multicenter cohort study including histopathology.

Subjects: Thirty-nine patients from 31 families with pathogenic variants in the CRX gene.

Preserving a qubit during state-destroying operations on an adjacent qubit at a few micrometers distance.

Protecting qubits from accidental measurements is essential for controlled quantum operations, especially during state-destroying measurements or resets on adjacent qubits, in protocols like quantum error correction. Current methods to preserve atomic qubits against such disturbances waste coherence time, extra qubits, and introduce additional errors. We demonstrate the feasibility of in-situ state-reset and state-measurement of trapped ions, achieving  >99.

The impact of the radiology career on family planning: A survey of practicing radiologists and trainees.

Purpose: As the field of medicine witnesses evolving attitudes towards work-life balance, barriers to family planning emerge as an important theme. Though these challenges have been investigated in many fields, there has been little work done on this subject within radiology. Here we present the first formal survey of radiologists on topics related to family planning.

Prognostic performance of the SCAI shock classification at admission and during ICU treatment: A retrospective, observational cohort study.

Background: Cardiogenic shock (CS) is characterized by high mortality and requires accurate prognostic tools to predict outcomes and guide treatment. The Society for Cardiovascular Angiography and Interventions (SCAI) shock classification indicates shock severity and can be used for outcome prediction.

Objective: Here, we compare the prognostic performance of SCAI shock classification determined on admission and during intensive care unit (ICU) stay.

Gelatinous Transformation of Bone Marrow Following Lymphoma and a Novel, Potential Treatment.

Gelatinous transformation of bone marrow (GTBM) is a rare hematologic condition in which hematopoietic cells in the bone marrow are replaced by extracellular gelatinous substances, often resulting in cytopenias. The true incidence of this condition is presently unknown, as the current body of literature primarily consists of case reports. However, an analysis of a large bone marrow registry suggests that this is a highly rare entity even among a population requiring bone marrow biopsy.

Virtual fitness buddy ecosystem: a mixed reality precision health physical activity intervention for children.

6-11-year-old children provide a critical window for physical activity (PA) interventions. The Virtual Fitness Buddy ecosystem is a precision health PA intervention for children integrating mixed reality technology to connect people and devices. A cluster randomized, controlled trial was conducted across 19 afterschool sites over two 6-month cohorts to test its efficacy in increasing PA and decreasing sedentary behavior.

Thoracic Ultrasound for Detection of Pneumothorax Following Thoracostomy Tube Removal in Trauma Patients.

Introduction: Screening for pneumothorax (PTX) is standard practice after thoracostomy tube removal, with postpull CXR being the gold standard. However, studies have shown that point-of-care thoracic ultrasound (POCTUS) is effective at detecting PTX and may represent a viable alternative. This study aims to evaluate the safety and efficacy of POCTUS for evaluation of clinically significant postpull PTX compared with chest x-ray (CXR).

Introducing the trier univalence neutrality ambivalence (TUNA) database: A picture database differentiating complex attitudes.

Using validated stimulus material is crucial for ensuring research comparability and replicability. However, many databases rely solely on bidimensional valence ratings, ranging from negative to positive. While this material might be appropriate for certain studies, it does not reflect the complexity of attitudes and therefore might hamper the unambiguous interpretation of some study results.

PEGylated Recombinant Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts.

In recent years, a novel treatment method for cancer has emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by arginine deaminases like the l-amino acid oxidase found in the ink toxin of the sea hare . Previously isolated from the ink, the l-amino acid oxidase was described to oxidate the essential amino acids l-lysine and l-arginine to their corresponding deaminated alpha-keto acids.

Feature-specific nutrient management of onion (Allium cepa) using machine learning and compositional methods.

While onion cultivars, irrigation and soil and crop management have been given much attention in Brazil to boost onion yields, nutrient management at field scale is still challenging due to large dosage uncertainty. Our objective was to develop an accurate feature-based fertilization model for onion crops. We assembled climatic, edaphic, and managerial features as well as tissue tests into a database of 1182 observations from multi-environment fertilizer trials conducted during 13 years in southern Brazil.

Sea-surface temperature pattern effects have slowed global warming and biased warming-based constraints on climate sensitivity.

The observed rate of global warming since the 1970s has been proposed as a strong constraint on equilibrium climate sensitivity (ECS) and transient climate response (TCR)-key metrics of the global climate response to greenhouse-gas forcing. Using CMIP5/6 models, we show that the inter-model relationship between warming and these climate sensitivity metrics (the basis for the constraint) arises from a similarity in transient and equilibrium warming patterns within the models, producing an effective climate sensitivity (EffCS) governing recent warming that is comparable to the value of ECS governing long-term warming under CO[Formula: see text] forcing. However, CMIP5/6 historical simulations do not reproduce observed warming patterns.

A 10-step participatory program for developing, implementing, and evaluating physical activity promoting actions in nursing homes in Germany.

Background: Since multidimensional barriers challenge nursing homes, a socio-ecological approach is needed for physical activity promotion in this setting. So far, little is known about how such an approach can be transferred into the successful development and implementation of PA-promoting actions together with stakeholders on-site. We aimed to investigate the actions and dimensions of PA-promoting actions and their sustainable implementation.

Do benzodiazepines reduce the efficacy of transcranial magnetic stimulation?

Objective: To investigate the effect of concomitant use of benzodiazepines on the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant major depressive disorder (TR-MDD).

Methods: This is a retrospective study comparing rTMS treatment outcomes between patients taking benzodiazepines ( = 59) and those who were not ( = 136). Participants completed the HAM-A, HAM-D17, MADRS and ZUNG at baseline and at the end of treatment.

[Sarcopenia, physical activity and sedentary behavior among nursing home residents in Germany].

Background: Residents in nursing homes show a high prevalence of the musculoskeletal syndrome sarcopenia and tend not to achieve current physical activity recommendations.

Objective: The aim of this study is to identify differences in physical activity and sedentary behavior of sarcopenic residents compared with nonsarcopenic and presarcopenic residents.

Methods: Sarcopenia assessment was performed among 63 nursing home residents in Baden-Wuerttemberg (D) using the European Working Group on Sarcopenia in Older People 2 specifications.

Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor System.

Bioprinting provides a powerful tool for regenerative medicine, as it allows tissue construction with a patient's specific geometry. However, tissue culture and maturation, commonly supported by dynamic bioreactors, are needed. We designed a workflow that creates an implant-specific bioreactor system, which is easily producible and customizable and supports cell cultivation and tissue maturation.

Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems.

Background: Aside to clinical changes, behavioral variant frontotemporal dementia (bvFTD) is characterized by progressive structural and functional alterations in frontal and temporal regions. We examined if there is a selective vulnerability of specific neurotransmitter systems in bvFTD by evaluating the link between disease-related functional alterations and the spatial distribution of specific neurotransmitter systems and their underlying gene expression levels.

Methods: Maps of fractional amplitude of low-frequency fluctuations (fALFF) were derived as a measure of local activity from resting-state functional magnetic resonance imaging for 52 bvFTD patients (mean age = 61.