Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.

Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals.

Methods And Results: The updated LIFE-CVD (i.

The blood microbiome and its association to cardiovascular disease mortality: case-cohort study.

Background: Little is known about the association between bacterial DNA in human blood and the risk of cardiovascular disease (CVD) mortality.

Methods: A case-cohort study was performed based on a 9 ½ year follow-up of the Oslo II study from 2000. Eligible for this analysis were men born in 1923 and from 1926 to 1932.

Oral health and cardiovascular disease risk factors and mortality of cerebral haemorrhage, cerebral infarction and unspecified stroke in elderly men: A prospective cohort study.

Stroke mortality comprises different specific diagnoses as cerebral infarction, different haemorrhagic conditions and unspecified stroke. This study seeks to explore the prediction of oral health indicators versus known cardiovascular disease risk factors for stroke mortality. Altogether, 12,764 men aged 58 to 77 years were invited to the health screening Oslo II in the year 2000.

Association of Cardiometabolic Multimorbidity With Mortality.

Importance: The prevalence of cardiometabolic multimorbidity is increasing.

Objective: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.

Design, Setting, And Participants: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128,843 deaths).

Agreement between referral information and discharge diagnoses according to Norwegian elective treatment guidelines - a cross-sectional study.

Background: Norway introduced 32 priority guidelines for elective health treatment in the specialist health service in the period 2008-9. The guidelines were intended to reduce large differences in waiting times among hospitals, streamline referrals and ensure that patients accessed the necessary healthcare to which they were entitled for certain conditions. Referral information guided the priorities.

The prevalence of childhood asthma in China: a systematic review.

Background: It is well known that the prevalence of asthma has been reported to increase in many places around the world during the last decades. Therefore, the aim of this study was to identify and review studies of asthma prevalence among children in China and address time trends and regional variation in asthma.

Methods: A systematic literature search was performed using PubMed and China National Knowledge Infrastructure (CNKI) databases.

Oral infection, regular alcohol drinking pattern, and myocardial infarction.

Oral infections have been associated with an increased risk for myocardial infarction (MI) and other cardiovascular diseases (CVD). Conversely, low, regular alcohol consumption is associated with a lower association of CVD. The objective was to test the novel hypothesis that oral infections are modified by regular alcohol drinking which has the effect of lowering the incidence of MI's.

Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy.

Background: Experimental evidence suggests a role for the β(2) -adrenergic receptor pathway in prostate cancer (PCa). We have investigated the association of β-blocker use with PCa incidence and survival in a Norwegian cohort.

Methods: Data from the Oslo II study in 2000 (n = 6515) were linked with information from the Cancer Registry of Norway and Statistics Norway.

Association between tooth extraction due to infection and myocardial infarction.

Objective: To explore whether the association between tooth extraction and nonfatal myocardial infarction (MI) varies by reason for extraction.

Methods: Men of the Oslo study of 1972/73 took part in the health survey in 2000 (n=6530) then aged 48-77 years. The present analysis is a nested case-control study of the men with a self-reported history of MI as cases (n=548) and randomly drawn controls (n=625).

European network for health technology assessment, EUnetHTA: planning, development, and implementation of a sustainable European network for health technology assessment.

Objectives: The European network on Health Technology Assessment (EUnetHTA) aimed to produce tangible and practical results to be used in the various phases of health technology assessment and to establish a framework and processes to support this. This article presents the background, objectives, and organization of EUnetHTA, which involved a total of sixty-four partner organizations.

Methods: Establishing an effective and sustainable structure for a transnational network involved many managerial, policy, and methodological tools, according to the objective of each task or Work Package.

Internal evaluation of the European network for health technology assessment project.

Objectives: The internal evaluation studied the development of the European network for Health Technology Assessment (EUnetHTA) Project in achieving the general objective of establishing an effective and a sustainable network of health technology assessment (HTA) in Europe.

Methods: The Work Package 3 group was dedicated to this task and performed the work. Information on activities during the project was collected from three sources.

Associations between environmental exposures and serum concentrations of Clara cell protein among elderly men in Oslo, Norway.

Cardiopulmonary morbidity and mortality is associated with several environmental exposures. Mechanistically, pathophysiological changes in the cardiopulmonary system may lead to the induction of inflammatory responses. In the present study we explored associations between environmental exposures and serum concentrations of lung Clara cell protein 16kDa, a biomarker that has recently been used to assess the integrity of the lung epithelium.

Repeated Weight Loss is Associated with the Metabolic Syndrome and Diabetes: Results of a 28 Year Re-screening of Men in the Oslo Study.

Objective: We investigated whether weight loss episodes were associated with the metabolic syndrome and diabetes in elderly men.

Design And Subjects: Men residing in Oslo and born in 1923-32 (n = 16,209) were screened for cardiovascular diseases and risk factors in 1972-73. Those who resided in the same area in the year 2000 were invited to a repeat physical and laboratory examination, attended by 6 410 men (mean age 72.

Weight cycling and risk of forearm fractures: a 28-year follow-up of men in the Oslo Study.

Weight cycling may lead to fractures in non-weight-bearing bone. The authors investigated the association between self-reported episodes of weight loss and forearm fracture in a cohort of elderly Norwegian men (n = 4,601; mean age = 71.6 years).

Associations between type A behaviour pattern and psychological distress : 28 years of follow-up of the Oslo Study 1972/1973.

Objective: To investigate the relationships between type A behaviour pattern (TABP) and psychological distress measured in middle aged men participating in two surveys 28 years apart.

Design And Subjects: Men residing in Oslo and born in 1923-1952 (all men aged 40-49 years and 7% of those aged 20-39 years--30,016 altogether) were invited to a cardiovascular screening in 1972/1973--asking about risk factors, symptoms and diseases. All the 17,972 participants were also asked questions about TABP (two items) and psychological distress (one item).

Leisure time physical activity in middle age predicts the metabolic syndrome in old age: results of a 28-year follow-up of men in the Oslo study.

Background: Data are scarce on the long term relationship between leisure time physical activity, smoking and development of metabolic syndrome and diabetes. We wanted to investigate the relationship between leisure time physical activity and smoking measured in middle age and the occurrence of the metabolic syndrome and diabetes in men that participated in two cardiovascular screenings of the Oslo Study 28 years apart.

Methods: Men residing in Oslo and born in 1923-32 (n = 16 209) were screened for cardiovascular diseases and risk factors in 1972/3.

Predictiveness of body mass index for fatal coronary heart disease in men according to length of follow-up: a 21-year prospective cohort study.

Aims: To test the association between body mass index (BMI) and other coronary risk factors and the risk of a fatal coronary heart disease (CHD) event in different time periods during follow-up.

Methods: Prospective cohort study with a 21 year follow-up period. A screened sample of 14,403 men aged 40-49 years initially free of CHD.

[Is a healthy lifestyle worthwhile?].

Background: The men invited to participate in the Oslo Study in 1972/3 were invited again to participate in the Oslo II study in 2000. We examined whether self-reported lifestyle habits were associated with biological markers, a range of symptoms and several illnesses in 2000.

Material And Methods: In addition to data from Oslo II, were data from those men of the Oslo-cohort who participated in 5 other studies between 1998 and 2001.

[Changes in cardiovascular risk factors among men in Oslo during 28 years].

Background: The aim of the study was to measure changes in known risk factors for cardiovascular disease among men over a period of 28 years.

Material And Methods: The present cohort study comprises a selection of men previously included in the Oslo-study of 1972/73. The men selected, were either followed-up in the Oslo II study (n = 5,323), or were included in five other studies in the period 1996-2001 (n = 1,834).

Transfusion vs. alternative treatment modalities in acute bleeding: a systematic review.

Background And Methods: The practice of transfusion varies a great deal between countries and hospitals. Therefore, a systematic literature review was performed to evaluate the evidence underlying practice of transfusion and alternative treatment modalities in acute bleeding. After a stepwise evaluation, 79 out of 2438 abstracts were approved as the evidence base.