Publications by authors named "Hagiwara E"
Article Synopsis
- The study investigates the effectiveness of immunosuppressants in patients with fibrotic hypersensitivity pneumonitis (HP), comparing those treated with prednisolone alongside immunosuppressants to those only receiving prednisolone without prior immunosuppressant treatment.
- A total of 42 patients were analyzed, revealing that the group receiving immunosuppressants showed a significant decline in forced vital capacity (FVC) before treatment, but no notable differences in FVC changes during the 12 months of treatment.
- Overall, both groups did not exhibit significant differences in disease progression or transplant-free survival rates after treatment, suggesting limited benefits of adding immunosuppressants to prednisolone in this context.
We evaluated the diagnostic performance of Rapiim SARS-CoV-2-H (Rapiim-H)-a point-of-care qualitative antigen test-using nasopharyngeal swabs (NPS) and saliva samples and compared its results with those from antigen quantification and nucleic acid amplification tests. NPS and saliva were collected from patients with confirmed and suspected coronavirus disease (COVID-19). In total, 142 NPS and saliva samples were collected.
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- The study investigates the relationship between Mycobacterium avium complex pulmonary disease (MAC-PD) and interstitial lung disease (ILD), highlighting characteristics specific to patients diagnosed with both conditions.
- Analysis was conducted on 54 patients with ILD and MAC-PD, revealing that these patients were generally older and had a lower BMI compared to a larger group of ILD patients.
- The findings indicate that MAC-PD in the context of ILD is associated with a higher rate of complications like chronic pulmonary aspergillosis and a poorer prognosis, especially in those with an unclassifiable imaging type.
Background: According to international diagnostic guidelines for hypersensitivity pneumonitis (HP), cases with both nonfibrotic and fibrotic lesions are classified by the predominant feature. Therefore, some cases with nonfibrotic HP, have inflammatory lesions alone, while others have a mixture of fibrosis and inflammation. We investigated the impact of slight fibrotic lesions in nonfibrotic HP.
View Article and Find Full Text PDFVarious symptoms emerge as immune-related adverse events of immune checkpoint inhibitor (ICI). A 73-year-old woman, a non-smoker, receiving chemotherapy including atezolizumab for lung adenocarcinoma, presented with fever, bilateral parotid swelling and sicca syndrome after four courses of chemotherapy. Because the lesions were not localized, the diagnosis was ICI-related sialadenitis rather than infectious.
View Article and Find Full Text PDFHerein, we report a case of 72-year-old man who had L858R EGFR-mutated lung adenocarcinoma. Chest computed tomography revealed a large lung mass that had completely replaced the right upper lobe. Although the mass dramatically shrank after initiating chemotherapy, non-malignant pleural effusion appeared.
View Article and Find Full Text PDFWe present a case of lung adenocarcinoma with malignant pleural effusion. Nineteen days after pleurodesis using minocycline and OK-432 (picibanil), pembrolizumab monotherapy was initiated. Four days later, the patient experienced a persistent cough.
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- Evaluating fibrotic hypersensitivity pneumonitis (HP) is difficult, with serum IgG testing typically used to identify associated antigens, but the effectiveness of testing multiple serum samples had not been explored.
- The study involved 28 patients with a history of HP, where serum IgG levels were measured using two different methods (ELISA and ImmunoCAP) to assess their relationship with changes in lung function, specifically forced vital capacity (FVC).
- Results indicated a significant negative correlation between changes in IgG antibody levels and FVC, meaning as IgG levels increased, lung function worsened, but additional treatments given during the study did not significantly change this outcome.
Background: In compatible with fibrotic hypersensitivity pneumonitis (HP) of the computed tomography (CT) classification using the American Thoracic Society (ATS)/Japanese Respiratory Society (JRS)/Latin American Thoracic Association (ALAT) HP guidelines, the lung fibrosis pattern was classified as either a usual interstitial pneumonia (UIP) pattern or a diffuse ground-glass opacity (GGO) pattern with subtle fibrosis. We investigated whether patients with the same imaging classification had different disease progression. We also attempted to reclassify these patients using the CHEST HP guidelines.
View Article and Find Full Text PDFBackground: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.
Methods: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021.
Amikacin liposome inhalation suspension (ALIS) is known to cause drug-related pneumonitis, which has been described as "hypersensitivity pneumonitis (HP)". However, its clinical and pathological characteristics have never been reported. We retrospectively evaluated 18 patients treated with ALIS.
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- A 73-year-old man with a persistent cough underwent chest CT scans, revealing lung abnormalities and elevated blood markers for inflammation.
- After conducting an antigen avoidance test, both his lung imaging and blood results showed improvement, leading to a diagnosis of hypersensitivity pneumonitis (HP).
- The source of his HP was traced to mold found on decaying walls in his home, highlighting the need for a systematic approach to identify the triggers of this condition.
Background: This prospective multicenter study assessed the prevalence of myocardial injury in patients with COVID-19 using cardiac magnetic resonance imaging (CMR).
Methods And Results: We prospectively screened 505 patients with moderate to severe COVID-19 disease from 7 hospitals in Japan. Of these patients, 31 (mean [±SD] age 63.
Invasive mucinous adenocarcinoma (IMA) of the lung is a rare variant of adenocarcinoma characterized by abundant intracytoplasmic mucin within the tumor. Although IMA has poor sensitivity to conventional chemotherapy regimens used for non-small cell lung cancer, we observed a better response to the bevacizumab (BEV) regimen. In this retrospective study, we aimed to investigate the response to BEV-combined regimens in patients with IMA.
View Article and Find Full Text PDFBackground: Upper-lung field pulmonary fibrosis (upper-PF), radiologically consistent with pleuroparenchymal fibroelastosis (PPFE), was reported to develop in patients with a history of asbestos exposure and tuberculous pleurisy, indicating that chronic pleuritis is correlated with upper-PF development. Round atelectasis reportedly emerges after chronic pleuritis. This study aimed to clarify the association between round atelectasis and upper-PF.
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- The study investigated the differences in acute exacerbation (AE) between fibrotic hypersensitivity pneumonitis (HP) and idiopathic pulmonary fibrosis (IPF).
- A total of 469 patients were analyzed, revealing that fibrotic HP had better survival rates and lower cumulative AE rates compared to IPF.
- The research concluded that while respiratory function tests predicted AE in fibrotic HP, high-resolution CT changes did not, indicating a differing prognostic significance between the two conditions.
Objective Dexamethasone, remdesivir (REM), and baricitinib (BAR) are commonly used to treat coronavirus disease 2019 (COVID-19). High-dose steroids have also been reported to be well tolerated, even when used in combination with multiple drugs. In this retrospective study, we assessed the safety and therapeutic efficacy of a three-drug combination of high-dose steroids, REM, and BAR in hospitalized COVID-19 patients.
View Article and Find Full Text PDFUnlabelled: We present the case of a 65-year-old male with multivessel coronary spasm presumably related to coronavirus disease 2019 (COVID-19). Acetylcholine coronary angiogram and cardiac magnetic resonance imaging were used for the diagnosis. As the precise pathophysiology of myocardial injury by COVID-19 remains unclear, the multimodality approach may contribute to the accurate diagnosis.
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- Patients with non-small cell lung cancer (NSCLC) often have driver mutations, like METex14 skipping, which is linked to the effectiveness of MET kinase inhibitors like Tepotinib.
- Tepotinib has a 46% overall response rate and provides a median response duration of 11.1 months, but diagnostic options in Japan are limited mostly to ArcherMET and AmoyDx tests.
- A case study of a 60-year-old man showed that he had a positive METex14 skipping result on the Oncomine Dx test but negative on ArcherMET, highlighting that Tepotinib may still be effective even when other tests yield lower read counts (like 46 in this case).
Background: In the two fibrotic hypersensitivity pneumonitis (fHP) diagnostic guidelines, the multidisciplinary discussion (MDD) is required to be performed in diagnosis of fHP, as in idiopathic pulmonary fibrosis (IPF) diagnostic guideline. Although some patients with fHP can improve disease condition during antigen avoidance, which can facilitate the diagnosis of fHP, it is unclear if MDD is necessary in all patients with suspected fHP who improved an antigen avoidance.
Objective: To investigate the diagnosis of fHP via MDD with positive antigen avoidance tests (AATs) and the clinical diagnosis with positive AATs.
Article Synopsis
- A study analyzed the rates and impact of respiratory bacterial infections in Japanese patients hospitalized with COVID-19, finding that 7.5% of patients experienced such infections.
- The most common causes of these infections included Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus pneumoniae, with more severe outcomes linked to hospital-acquired infections and pre-existing health conditions.
- The research highlights the importance of monitoring and assessing bacterial complications in COVID-19 patients, as these infections can significantly increase mortality rates.
Article Synopsis
- - The study focuses on the relationship between thromboembolism and BRAF V600E-mutant non-small-cell lung cancer, discovering that nearly half of the patients experienced thrombotic events within a year.
- - Out of 10 patients analyzed, 5 had seven thromboembolic occurrences, including four cancer-related strokes and three venous events, linking early strokes to poor outcomes.
- - The findings suggest that the presence of cancer-related strokes can indicate a worse prognosis for patients with this specific lung cancer mutation.
Article Synopsis
- The study examined the impact of non-respiratory bacterial and fungal infections on hospitalized COVID-19 patients, focusing on the types of infections, their causative organisms, and their effects on mortality rates.
- Out of 1914 patients, 4.2% developed non-respiratory bacterial infections, predominantly bacteremia, which was linked to a higher risk of death, particularly in patients with certain predisposing factors.
- The findings highlight the need for effective medical strategies to manage secondary infections in COVID-19 patients, especially those at a greater risk, such as older individuals and those admitted to intensive care.
Introduction: The accuracy of serum immunoglobulin (Ig) G testing for diagnosis of stable bird-related fibrotic hypersensitivity pneumonitis (HP) is controversial. Furthermore, avian serum, extracts, or feathers were employed as antigens in bird-related HP; however, the usage of egg whites has not been reported. We investigated the utility of IgG testing against pigeon egg whites in patients with stable bird-related fibrotic HP.
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