Publications by authors named "Hagit Barsheshet"
Adv Sci (Weinh)
July 2023
Article Synopsis
- Multiple myeloma (MM) is an incurable cancer affecting plasma cells in the bone marrow, making treatment challenging despite new drugs.
- Researchers developed targeted lipid nanoparticles (tLNPs) coated with an anti-CD38 antibody to deliver RNA therapies directly to MM cells, significantly reducing cell viability in vitro.
- The study also introduced a new mouse model that mimics human MM, demonstrating effective delivery of tLNPs to MM cells and improved treatment outcomes in these mice, highlighting the potential of RNA-based therapies in managing MM.
