Development of a novel geometrically-parametric patient-specific finite element model for anterior cruciate ligament reconstruction.

Purpose: A personalized model of the knee joint, with adjustable effective geometric parameters for the transplanted autograft diameter in Anterior Cruciate Ligament Reconstruction (ACLR) using the bone-patella-tendon-bone (BPTB) technique, has been developed. The model will assist researchers in understanding how different graft sizes impact a patient's recovery over time.

Methods: The study involved selecting a group of individuals without knee injuries and one patient who had undergone knee surgery.

Low-level laser therapy and laser acupuncture therapy for pain relief after initial archwire placement : A randomized clinical trial.

Objective: Pain is among the most unpleasant experience during fixed orthodontic therapy. This study compared the effectiveness of low-level laser therapy (LLLT) and laser acupuncture therapy (LAT) in pain reduction after initial archwire placement.

Methods: This randomized, parallel-group, single-blind clinical trial included 60 female patients who required four premolar extractions to relieve crowding.

FEM thermal assessment of a 3-D irregular tumor with capillaries in magnetic nanoparticle hyperthermia via dissimilar injection points.

In this study, simulation of magnetic nanoparticle hyperthermia is performed on a 3D tumor model constructed based on a CT image of a tumor. In the first step, magnetic nanoparticles are injected into two points of the tumor tissue with the same parameters. Results show that temperature profiles in the vicinity of the injection points are not similar due to the presence of blood capillaries.

Simulation of heat transfer, mass transfer and tissue damage in magnetic nanoparticle hyperthermia with blood vessels.

Numerical simulation of magnetic nanoparticle hyperthermia for cancer treatment has been investigated in this study. The presented simulation did account for the effects of fluid flow, mass flow, and heat transfer during the MNP hyperthermia. The tumor was assumed to be a porous slab, 30% of which had been necrosed previously, with two capillaries, where magnetic nanoparticles were added into the bloodstream and distributed in the tumor by blood flow through capillaries.

The Effects of Chronic Ankle Instability on the Biomechanics of the Uninjured, Contralateral Ankle During Gait.

Objective: To determine whether unilateral chronic ankle instability (CAI) affects the kinematics of the uninjured contralateral ankle.

Methods: In this case-control study, 15 adult patients with unilateral CAI and 15 healthy controls were studied. Both the unstable and uninjured ankles in patients with unilateral CAI (CAI group, n = 15) were compared with that of healthy individuals (control group, n = 15).

Using different unit-cell geometries to generate bone tissue scaffolds by additive manufacturing technology.

The design and manufacturing three-dimensional scaffolds are a significant concept in bone tissue engineering (BTE). Firstly, from the perspective of manufacturing, Additive manufacturing (AM) technology has achieved great attraction in the field of BTE during the past few years. In the field of BTE, the possibility of generating complex porous structures with high precision compared to typical manufacturing methods has made AM the leading option for scaffold production.

Does ipsilateral chronic ankle instability alter kinematics of the other joints of the lower extremities: a biomechanical study.

Purpose: We evaluated and compared kinematics of bilateral ankle, knee, and hip joints in patients with chronic unilateral ankle instability (CAI) with healthy controls.

Methods: Fifteen individuals diagnosed with CAI and a control group of 16 individuals were matched. Different peaks within the gait cycle (at different intervals) for the dorsiplantar, inversion/eversion, and abduction/adduction axis were compared between injured and uninjured sides of patients with CAI with a control group.

Biomechanics Following Anatomic Lateral Ligament Repair of Chronic Ankle Instability: A Systematic Review.

One of the most common orthopedic injuries in the general population, particularly among athletes, is ankle sprain. We investigated the literature to evaluate the known pre- and postoperative biomechanical changes of the ankle after anatomic lateral ligament repair in patients suffering from chronic ankle instability. In this systematic review, studies published till January 2020 were identified by using synonyms for "kinetic outcomes," "kinematic outcomes," "Broström procedure," and "lateral ligament repair.

Synthesis of Core-Shell Magnetic Supramolecular Nanocatalysts based on Amino-Functionalized Calix[4]arenes for the Synthesis of -Chromenes by Ultrasonic Waves.

One of the most common phenol-formaldehyde cyclic oligomers from hydroxyalkylation reactions that exhibit supramolecular chemistry are calixarenes. These macrocyclic compounds are qualified to act as synthetic catalysts due to their specific features including being able to form host-guest complexes, having unique structural scaffolds and their relative ease of chemical modifications with a variety of functions on their upper rim and lower rim. Here, a functional magnetic nanocatalyst was designed and synthesized by using a synthetic amino-functionalized calix[4]arene.

Computational simulation of the multiphasic degeneration of the bone-cartilage unit during osteoarthritis via indentation and unconfined compression tests.

It has been experimentally proposed that the discrete regions of articular cartilage, along with different subchondral bone tissues, known as the bone-cartilage unit, are biomechanically altered during osteoarthritis degeneration. However, a computational framework capturing all of the dominant changes in the multiphasic parameters has not yet been developed. This article proposes a new finite element model of the bone-cartilage unit by combining several validated, nonlinear, depth-dependent, fibril-reinforced, and swelling models, which can computationally simulate the variations in the dominant parameters during osteoarthritis degeneration by indentation and unconfined compression tests.

Publisher Correction: Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network.

In the version of this article originally published, the x axis labels in Fig. 1a were incorrect. The labels originally were 'Specificity,' but should have been '1 - Specificity.

Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network.

Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow. Widely available digital ECG data and the algorithmic paradigm of deep learning present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive evaluation of an end-to-end deep learning approach for ECG analysis across a wide variety of diagnostic classes has not been previously reported.

A finite element study on intra-operative corrective forces and evaluation of screw density in scoliosis surgeries.

Scoliosis is an abnormal sideways curvature of the spine and rib cage, which may need surgical treatments. Most of the corrective maneuvers in scoliosis surgeries are based on surgeon's experience; hence, there is great interest of understanding how the correction ratio can be influenced by the magnitude of forces and moments. Therefore, the objective of this study was to develop and validate a detailed finite element model of the thoracolumbar which can be used to simulate the scoliosis surgeries based on patient-specific clinical images.

Plantar Static Pressure Distribution in Normal Feet Using Cotton Socks with Different Structures.

Background: The major goal of investigating plantar pressure in patients with pain or those at risk for skin injury is to reduce pressure under prominent metatarsal heads, especially the first and second metatarsals. In research, the insole is used to reduce plantar pressure by increasing the contact area in the midfoot region, which, in turn, induces an uncomfortable feeling near the arch during walking. It is deduced that sock structure can redistribute plantar pressure distribution.

Effect of socks structures on plantar dynamic pressure distribution.

A major purpose of investigating the plantar pressure in patients with pain or those at risk for skin injury is to reduce the pressure below metatarsal heads, specially first and second metatarsal heads. The aim of this article is to evaluate the effects of the socks structures on the changes in plantar dynamic pressure. In this study, seven socks types with different structures for the sole area were produced.

Thermal analysis of magnetic nanoparticle in alternating magnetic field on human HCT-116 colon cancer cell line.

Purpose: The purpose of this study was to closely investigate the effects of heat dissipation of superparamagnetic nanoparticles on HCT-116 human cancer cell lines cultured under laboratory conditions and also to examine important parameters including size and concentration of nanoparticles, magnetic field frequency, magnetic field intensity, and exposure time.

Materials And Methods: Conducting experimental tests required special hardware capable of producing an AC magnetic field with various frequencies. The design and construction process for such an experimental set-up is presented here.

Effect of heat dissipation of superparamagnetic nanoparticles in alternating magnetic field on three human cancer cell lines in magnetic fluid hyperthermia.

Purpose: The purpose of this study was to propose a method for constructing the software setup required for investigating thermal effect of superparamagnetic nanoparticles on three human cell lines. This article aimed to examine the required nanoparticle dose, frequency, field intensity and the exposure time.

Materials And Methods: In the present study, first some general details were given about design and construction of the setup required for generating a safe magnetic field in order to examine the thermal effect of superparamagnetic nanoparticles on three human cancer cell lines, cultured under laboratory conditions.

Recovering the mechanical properties of denatured intervertebral discs through Platelet-Rich Plasma therapy.

Degenerative disc disease is one of the most common causes of low back pain instigating huge socioeconomic costs and posing an immense burden on healthcare systems worldwide. New therapeutic approaches to damaged intervertebral discs are therefore of great interest. Platelet-Rich Plasma (PRP) has been proposed for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding its effectiveness and influence on disc material properties.

Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury.

Introduction: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program.

Methods: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor (G-CSF) along with rehabilitation program.

Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disk Under Cyclic Loading - A Meta-Model Analysis of Finite Element Simulations.

The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disk degeneration results in degradation of disk solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid-fluid interactions of degenerative disks to cyclic loadings are not well studied yet.

Evaluation of the effects of injection velocity and different gel concentrations on nanoparticles in hyperthermia therapy.

Background And Objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.

Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used.

Scoring consensus of multiple ECG annotators by optimal sequence alignment.

Development of ECG delineation algorithms has been an area of intense research in the field of computational cardiology for the past few decades. However, devising evaluation techniques for scoring and/or merging the results of such algorithms, both in the presence or absence of gold standards, still remains as a challenge. This is mainly due to existence of missed or erroneous determination of fiducial points in the results of different annotation algorithms.

Cylindrical agar gel with fluid flow subjected to an alternating magnetic field during hyperthermia.

Purpose: In magnetic fluid hyperthermia (MFH), nanoparticles are injected into diseased tissue and subjected to an alternating high frequency magnetic field. The process triggers sufficient heat to destroy the cancerous cells. One of the challenging problems during MFH is blood flow in tissue.

Fetal QRS extraction from abdominal recordings via model-based signal processing and intelligent signal merging.

Noninvasive fetal ECG (fECG) monitoring has potential applications in diagnosing congenital heart diseases in a timely manner and assisting clinicians to make more appropriate decisions during labor. However, despite advances in signal processing and machine learning techniques, the analysis of fECG signals has still remained in its preliminary stages. In this work, we describe an algorithm to automatically locate QRS complexes in noninvasive fECG signals obtained from a set of four electrodes placed on the mother's abdomen.

Analysis of different material theories used in a FE model of a lumbar segment motion.

In this study, a nonlinear poroelastic model of intervertebral disc as an infrastructure was developed. Moreover, a new element was defined consisting a disc (Viscoelastic Euler Beam Element) and a vertebra (Rigid Link) as a unit element. Using the new element, three different viscoelastic finite element models were prepared for lumbar motion segment (L4/L5).