The outcomes of children with primary malignant renal tumors: a 14-year single-center experience.

Background: Wilms tumor (WT) is the most common malignant renal tumor in children. This study investigated the clinical features, pathological findings, and outcomes of children with malignant renal tumors in Southern Iran. Factors associated with recurrence and mortality were assessed.

Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study.

Purpose: Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan) for assessing liver fibrosis in patients with pediatric cancer.

Methods: We enrolled 106 consecutive cases of acute leukemia in individuals under 21 years of age.

Modeling and control of COVID-19 disease using deep reinforcement learning method.

The prevalence of epidemics has been studied by researchers in various fields. In the last 2 years, the outbreak of COVID-19 has affected the health, economy, and industry of communities around the world and has caused the death of millions of people. Therefore, many researchers have tried to model and control the prevalence of this disease.

The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis.

This meta-analysis evaluated the impact of prophylactic post-chemotherapy granulocyte colony-stimulating factor (G-CSF) in patients with acute myeloid leukemia (AML). Overall, the relapse rate, overall survival, event-free survival, and mortality rate were similar in G-CSF (+) compared to G-CSF (-) patients. However, the relative risk (RR) of relapse was higher in children and in secondary AML patients who were treated with G-CSF compared to the G-CSF (-) group [RR, 95% confidence interval: 1.

Abnormal frequency of the memory B cell subsets and plasmablasts in patients with congenital severe hemophilia A: correlation with "Inhibitor" formation.

Background: Development of antibodies against infused Factor VIII (FVIII) or "inhibitors" represents a major challenge following FVIII replacement therapy in patients with hemophilia A (HA). Recent studies have shown that certain cellular compartments of the immune system contribute to the production of such antibodies. Herein, we determined the frequency of class-switched CD19IgDCD27/non-class-switched CD19IgDCD27 memory B cell subsets and CD19CD27CD38 plasmablasts in patients with severe HA and their association with the development of inhibitors in these patients.

Iron Overload in Children With Leukemia; Identification of a Cutoff Value for Serum Ferritin Level.

Objective: To determine the prevalence of iron overload in children with acute lymphoblastic leukemia (ALL) after treatment cessation and establish a cutoff value for serum ferritin level as an indicator of iron overload.

Background: Early detection and monitoring of iron overload in patients with leukemia is crucial.

Methods: In this prospective cohort study, 66 pediatric patients with ALL who were treated at a tertiary referral center affiliated with Shiraz University of Medical Sciences in Shiraz, Southern Iran, were investigated from July 2020 to December 2022.

The Prevalence of Obstructive Sleep Apnea and Associated Symptoms among Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis.

Previous studies have shown that patients with sickle cell disease (SCD) are at high risk for obstructive sleep apnea (OSA). In the current study, we aimed to systematically review the literature to address the prevalence of OSA and associated symptoms among patients with SCD. Electronic databases, including Web of Science, Scopus, PubMed, Google Scholar, and Embase were systematically searched to identify the relevant original articles on patients with SCD.

The efficacy of L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial.

Introduction: Febrile neutropenia is a serious complication of cancer chemotherapy that can result in delays in treatment. This study evaluates the efficacy of L. at neutrophil recovery time in children with chemotherapy-associated febrile neutropenia.

Skeletal complications in patients with hemophilia: a single-center experience.

Background: Arthropathy is a common complication in patients with hemophilia. We examined the prevalence of this skeletal complication in patients with hemophilia who were registered at a Comprehensive Hemophilia Center in Shiraz, Southern Iran.

Materials And Methods: In this cross-sectional study, an orthopedic specialist visited 448 patients and conducted screenings for skeletal complications.

Investigating the trends of incidence rates of breast cancer in Southern Iran: a population based survey.

Background: The overall incidence of breast cancer is different all over the world and even within a nation. The present study aims to investigate the stratum-specific incidence trends of breast cancer in southern Iran.

Methods: In this retrospective cohort study, the data of Fars Population-Based Cancer Registry was used during 2001-2018.

Modeling and Robust Control of a 5 DOF Model for Rowing Motion by Inverse Dynamics Method.

Background: Competitive sailing requires efforts pertinent to physiological limitations and coordination between different parts of the body. Such coordination depends on the torques applied by muscles to the joints.

Objective: This study aims to simulate the motion and provide a control law for the joint torques in order to track the desired motion paths.

The impact of inhibitors on the quality of life in patients with hemophilia.

Objective: To investigate the association of health-related quality of life in hemophilia patients with inhibitor and clinical and demographic characteristics.

Methods: In this multi-center cross-sectional study, 41 male patients with hemophilia A were investigated from May to October 2021. All patients were registered at the Hemophilia Clinic affiliated with Shiraz and Zahedan Universities of Medical Sciences in Iran.

Risk Factors for the Occurrence of Asymptomatic Brain Lesions in Patients with β-Thalassemia: a Systematic Review and Meta-Analysis.

Background: Several factors, including increased platelet aggregation, decreased platelet survival, decreased antithrombotic factors cause a hypercoagulable state in thalassemia patients. This is the first meta-analysis designed to summarize the association of age, splenectomy, gender, and serum ferritin and hemoglobin levels with the occurrence of asymptomatic brain lesions in thalassemia patients using MRI.

Methods: This systematic review and meta-analysis was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist.

Correlation of Serum Ferritin Level with Heart T2 MRI in Transfusion Dependent Thalassemia: a Systematic Review and Meta-Analysis.

Background: Cardiac complications in patients with transfusion-dependent thalassemia (TDT) are one of the major causes of mortality in these patients which annually impose economic burden on the endemic countries. Heart T2 MRI is a good modality for evaluating iron overload. Our aim was to investigate the pooled correlation between the serum ferritin level and heart iron overload in TDT patients and compare the effect size in different geographical areas.

Prediction of Heart and Liver Iron Overload in β-Thalassemia Major Patients Using Machine Learning Methods.

Patients with β-thalassemia major (β-TM) face a wide range of complications as a result of excess iron in vital organs, including the heart and liver. Our aim was to find the best predictive machine learning (ML) model for assessing heart and liver iron overload in patients with β-TM. Data from 624 β-TM patients were entered into three ML models using random forest (RF), gradient boost model (GBM), and logistic regression (LR).

The survival of childhood leukemia: An 8-year single-center experience.

Background: The survival of childhood leukemia has improved. We aimed to report the survival rate and the associated factors in children with acute leukemia during an 8-year follow-up.

Aims: This study investigates the 8-year survival rates of children with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in Shiraz, the largest oncology center in Southern Iran.

Cytokine Levels in Patients with β-Thalassemia Major and Healthy Individuals: a Systematic Review and Meta-Analysis.

Background: Cytokine levels in patients with β-thalassemia major (β-TM) have been assessed in several studies. Accordingly, a wide variety of immune disturbances has been shown in patients with thalassemia. Recurrent transfusions cause iron overload, which induces an increase in the production of cytokines.

Thromboprophylaxis Outcome in Childhood SARS-CoV-2 Infection: A Single-Center Experience.

Background: The SARS-CoV-2 infection has been associated with potentially endothelial damage and coagulation cascade activation that cause thrombosis. There is limited information on thrombosis and anticoagulant therapy in children with coronavirus disease 2019 (COVID-19).

Aims: This study evaluates the outcome of thromboprophylaxis in children younger than 18-year old with COVID-19 infection.

Comparison of Kinematic Movement Patterns Between 2 Subgroups of Females With Low Back Pain and Healthy Women During Sit-to-Stand and Stand-to-Sit.

The purpose of study was to compare the kinematic patterns of the thoracic, lumbar, and pelvis segments and hip joints between 2 low back pain subgroups and healthy women during sit-to-stand and stand-to-sit. Kinematic data of 44 healthy women and 2 subgroups of females with low back pain in 2 subgroups of movement system impairment model (rotation-extension [Rot.Ext] and rotation-flexion [Rot.

Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia.

Background: Structural ophthalmologic findings have been reported in patients with β-thalassemia due to chronic anemia, iron overload, and iron chelation therapy toxicity in few previous studies. We aimed to investigate structural ocular findings and their relationship with hematological parameters in patients with transfusion-dependent β-thalassemia (TDT).

Methods: In this cross-sectional study, from January 2018 to January 2019, 39 patients with TDT over the age of 18 participated.