Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light.

Background: Photothermal therapy (PTT) is one of the effective and non-invasive strategies which hold great promise for improving the treatment of cancer cells. PTT is based on activating a photosensitizer by infrared light irradiation and producing heat and reactive species and apoptosis in the tumor area.

Objective: The aim of this study was to investigate the effect of photothermal/chemotherapy on melanoma cancer cells using poly (2-amino phenol)/gold (P2AO/AuNPs) and doxorubicin (DOX).

Synchronized Chemotherapy/Photothermal Therapy/Sonodynamic Therapy of Human Triple-Negative and Estrogen Receptor-Positive Breast Cancer Cells Using a Doxorubicin-Gold Nanoclusters-Albumin Nanobioconjugate.

Objective: Novel strategies for treating triple-negative breast cancer (TNBC) are ongoing because of the lack of standard-of-care treatment. Nanoframed materials with a protein pillar are considered a valuable tool for designing multigoals of energy-absorbing/medication cargo and are a bridge to cross-conventional treatment strategies.

Methods: Nanobioconjugates of gold nanoclusters-bovine serum albumin (AuNCs-BSA) and doxorubicin-AuNCs-BSA (Dox-AuNCs-BSA) were prepared and employed as a simultaneous double photosensitizer/sonosensitizer and triple chemotherapeutic/photosensitizer/sonosensitizer, respectively.

Beyond Conventional Monitoring: A Semantic Segmentation Approach to Quantifying Traffic-Induced Dust on Unsealed Roads.

Road dust is a mixture of fine and coarse particles released into the air due to an external force, such as tire-ground friction or wind, which is harmful to human health when inhaled. Continuous dust emission from the road surfaces is detrimental to the road itself and the road users. Due to this, multiple dust monitoring and control techniques are currently adopted in the world.

Institutionalization for good governance to reach sustainable health development: a framework analysis.

Background: This article explores the concept of institutionalization, which is the process of transforming ideas into programs and automating actions, in the context of health system governance and sustainable development. Institutionalization is a key mechanism for creating accountable and transparent institutions, which are essential for achieving health system resilience and sustainability. This study identifies the components and dimensions of institutionalization in the health system and its relationship with good governance and sustainable health development.

An amplified sonodynamic therapy by a nanohybrid of titanium dioxide-gold-polyethylene glycol-curcumin: HeLa cancer cells treatment in 2D monolayer and 3D spheroid models.

The utilization of ultrasound (US) to activate sonosensitizers for sonodynamic therapy (SDT) has faced challenges such as low activation efficiency and limited therapeutic outcomes, which have hampered its clinical applications. In this study, a nanohybrid of titanium dioxide-gold-polyethylene glycol-curcumin (TiO-Au-PEG-Cur NH), as a novel US sensitizer, was synthesized, characterized, and applied for SDT of HeLa cancer cells in 2D monolayer model, and also a 3D spheroid model to bridge the gap between 2D cell culture and in vivo future studies. TiO-Au-PEG-Cur NH contained TiO nanoparticles of 36 ± 11 nm in diameter, PEG-curcumin as a filler, and gold nanoparticles of 21 ± 7 nm in diameter with a high purity and a 35:17 of Ti:Au ratio (W/W), and it had a band gap of 2.

Study the Anticancer Properties of Thymol-Loaded PEGylated Bovine Serum Albumin Nanoparticles Conjugated with Folic Acid.

Phenolic compounds such as Thymol have an effective role in suppressing cancer, however, their low solubility in aqueous solution has limited their use. This study aimed to prepare Thymol (TY)-loaded bovine serum albumin (BSA) nanoparticles surface-modified with polyethylene glycol (PEG) conjugated with folic acid (FA) and evaluate their inhibitory activity on cancer cells. The TY-BSA-PEG-FA was characterized using DLS, FESEM, and FTIR.

Exploiting Big Data for Experiment Reporting: The Hi-Drive Collaborative Research Project Case.

As timely information about a project's state is key for management, we developed a data toolchain to support the monitoring of a project's progress. By extending the Measurify framework, which is dedicated to efficiently building measurement-rich applications on MongoDB, we were able to make the process of setting up the reporting tool just a matter of editing a couple of .json configuration files that specify the names and data format of the project's progress/performance indicators.

Pulsed sonodynamic therapy of melanoma cancer cells using nanoparticles of and mesoporous platinum.

Objective: Noble metal nanomaterials have been introduced as ideal sonosensitizers for sonodynamic therapy (SDT) of cancer. In this research, platinum nanoparticles (PtNPs) and mesoporous platinum (MPt) were first synthesized and then evaluated as novel sonosensitizers.

Methods: Ultrasound waves were radiated at two different power densities and two different pulse ratios to develop a pulsed radiation route for SDT of the malignant melanoma cell line C540 (B16/F10).

Correction: Bigi et al. Waste Orange Peels as a Source of Cellulose Nanocrystals and Their Use for the Development of Nanocomposite Films. 2023, , 960.

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Waste Orange Peels as a Source of Cellulose Nanocrystals and Their Use for the Development of Nanocomposite Films.

To date, approximately 30-50% of food is wasted from post-harvesting to consumer usage. Typical examples of food by-products are fruit peels and pomace, seeds, and others. A large part of these matrices is still discarded in landfills, while a small portion is valorized for bioprocessing.

A benchmark dataset for binary segmentation and quantification of dust emissions from unsealed roads.

The generation of reference data for machine learning models is challenging for dust emissions due to perpetually dynamic environmental conditions. We generated a new vision dataset with the goal of advancing semantic segmentation to identify and quantify vehicle-induced dust clouds from images. We conducted field experiments on 10 unsealed road segments with different types of road surface materials in varying climatic conditions to capture vehicle-induced road dust.

Does maturity estimation, 2D:4D and training load measures explain physical fitness changes of youth football players?

Objectives: The purpose of the present study was two-fold: (1) To analyse physical fitness changes of youth football players after a full-season; and (2) to examine whether physical fitness changes are explainable by estimated maturity status, 2digit:4digit ratio (2D:4D) from each hand and training load (TL) measures.

Methods: Twenty-seven youth elite Under-15 football players were daily monitored for training load measures during 38 weeks. At the beginning and at the end of the season, all players were assessed for physical fitness.

Relationship between donated kidney volume determined by ultrasound adjusted for clinical factors and 1-month and 1-year creatinine clearance: A retrospective study.

Background: Graft volume as a surrogate of nephron numbers correlates with allograft function. The primary aim of this study was to correlate renal volume determined by ultrasound, adjusted to recipient clinical parameters in order to determine post-transplant renal function at the end of the first year.

Materials And Methods: A total of 140 patients were enrolled in this study, including 75 males, with a total mean age of 41.

Response Time and Causes of Delay in Prehospital Emergency Missions in Mashhad, 2015.

The response time is considered as one of the most important criteria for the quality of given care to the injured. This research aimed to investigate the frequency and causes of prehospital emergency delays in the 115 emergency center, in city of Mashhad, in 2015. In this cross-sectional study, 21,142 missions performed in 2015 were investigated, from among which 640 missions with delays in systematic sampling were recognized.

Application of ICT in effective crisis management: A systematic review.

Introduction: Effective crisis management can reduce the costs and consequences of a crisis and has a significant impact on saving human lives in critical situations. Proper use of information and communication technologies (ICTs) can improve all crisis management phases and crisis communication cycles according to the needs of stakeholders. The purpose of this review article is to identify which ICTs have been used in effective crisis management and what managerial tasks they support.

Assessing effectiveness of Komagataeibacter strains for producing surface-microstructured cellulose via guided assembly-based biolithography.

In this study, a medical device made of surface microstructured bacterial cellulose was produced using cellulose-producing acetic acid bacteria wild-type strains in combination with guided assembly-based biolithography. The medical device aims at interfering with the cell's focal adhesion establishment and maturation around implantable devices placed in soft tissues by the symmetrical array on its surface. A total of 25 Komagataeibacter strains was evaluated over a three-step selection.

Impact of different dietary lutein levels on growth performance, biochemical and immuno-physiological parameters of oriental river prawn (Macrobrachium nipponense).

A 56-day trial was conducted to evaluate the effects of dietary lutein pigment on growth, biochemical, and immuno-physiological parameters of the oriental river prawn. Prawns were fed five formulated diets containing different lutein levels, 0 (control), 50, 100, 150, and 200 mg/kg. Growth performance, except hepatosomatic index, was affected by different lutein levels, and biochemical parameters (urea, uric acid, glucose, creatinine, and triglycerides) decreased.

Association between Training Load and Well-Being Measures in Young Soccer Players during a Season.

This study aimed to analyze the correlations among weekly (w) acute workload (wAW), chronic workload (wCW), acute/chronic workload ratio (wACWR), training monotony (wTM), training strain (wTS), sleep quality (wSleep), delayed onset muscle soreness (wDOMS), fatigue (wFatigue), stress (wStress), and Hooper index (wHI) in pre-, early, mid-, and end-of-season. Twenty-one elite soccer players (age: 16.1 ± 0.

COVID-19 and Comparative Health Policy Learning; the Experience of 10 Countries.

Background: Since December 2019, the world has been facing one of the most critical health threats of the last decades. In March 2021, the official number of deaths passed 2.6 million worldwide.

Quantification of training and match load in elite youth soccer players: a full-season study.

Background: The present study aimed to quantify training and match load in elite young soccer players over the course of an entire season.

Methods: Using a longitudinal design, session-rate of perceived exertion (s-RPE) and its metrics (weekly acute workload [wAW], acute to chronic workload ratio [wACWR], training monotony and training strain) were examined in twenty-one elite young soccer players (mean±standard deviation; age: 16.1±0.

Automatic Evaluation of Crown Preparation Using Image Processing Techniques: A Substitute to Faculty Scoring in Dental Education.

Background: This study presents a new and innovative experimental method, including software and its prerequisite instruments, to use image processing techniques for crown preparation analysis.

Method: A platform was designed and constructed to take images from artificial teeth in different angles and directions and to process and analyze them by the proposed method to evaluate the quality and quantity of crown preparation. For each tooth, two series of images were taken from the artificial teeth before and after preparation, and image series were registered by two semi-automated and automated methods to transform them into one coordinate system.

Suitability Assessment of PLA Bottles for High-Pressure Processing of Apple Juice.

The aim of the present study is to assess the use of polylactic acid (PLA) bottles as an alternative to polyethylene terephthalate (PET) ones for high-pressure processing (HPP) of apple juice. The treatment of PLA bottles at 600 MPa for 3 min did not cause alterations in the packaging shape and content, confirming the suitability of PLA bottles to withstand HPP conditions as well as PET bottles. Quantification of total mesophilic bacterial and fungal load suggested HPP treatment can be effectively applied as an alternative to pasteurization for apple juice packed in PLA bottles since it guarantees microbial stability during at least 28 days of refrigerated storage.

COVID-19 Pandemic and Comparative Health Policy Learning in Iran.

Background: On March 11, 2020, the World Health Organization (WHO) declared the novel coronavirus disease (COVID-19) a global pandemic. Starting in December 2019 from China, the first cases were officially announced on February 19 in Qom city, Iran. As of April 3, 2020, 206 countries have reported a total of 932166 cases with 46764 deaths.

The Factors Associated With Direct Medical Costs in Patients With Gastric Cancer: Quantile Regression Approach Compared With Gamma Regression.

Objectives: Evaluating the costs of illness can provide evidence to improve performance at all levels of health organizations. This study aimed to identify the relationship between the costs of diagnosing and treating patients with gastric cancer and their explanatory variables, using quantile and gamma regressions and comparing the results of the two models.

Methods: This was a cross-sectional and descriptive-analytic study carried out in 2016.