Comparing the efficacy of intra-articular injection of Platelet Rich Plasma (PRP) with corticosteroids (CS) in patients with chronic zygapophyseal joint low back pain confirmed by double intra-articular diagnostic blocks: A triple-blinded randomized multicentric controlled trial with a 6-month follow-up.

Objective: To compare the safety and effectiveness in improving function and reducing pain of autologous PRP to corticosteroid (CS) zygapophyseal (Z-joint) intra-articular (IA) injections at six months for patients with chronic osteoarthritis Z-joint mediated low back pain (LBP).

Design: Prospective triple-blinded multicentric randomized controlled trial.

Methods: Fifty participants with radiological signs of Z-joint OA and chronic Z-joint mediated LBP confirmed by a ≥80 % pain improvement after two IA local anesthetic injections were randomized into PRP and CS groups, using a 1:1 ratio.

Sensitivity analysis of an inertial calibration method: Influence of leg position on 3D knee kinematics.

Background: Inertial systems are increasingly used to analyze human motion, especially for gait analyses and in clinical settings. Calibration methods for these systems are designed for ease of implementation, and previous studies have shown that they can provide accurate knee kinematics in the sagittal plane. However, the reason of their lack of accuracy in the other planes (i.

Unveiling distinct kinematic profiles among total knee arthroplasty candidates through clustering technique.

Background: Characterizing the condition of patients suffering from knee osteoarthritis is complex due to multiple associations between clinical, functional, and structural parameters. While significant variability exists within this population, especially in candidates for total knee arthroplasty, there is increasing interest in knee kinematics among orthopedic surgeons aiming for more personalized approaches to achieve better outcomes and satisfaction. The primary objective of this study was to identify distinct kinematic phenotypes in total knee arthroplasty candidates and to compare different methods for the identification of these phenotypes.

Evaluation of a method to quantify posture and scapula position using biplanar radiography.

Background: Recent studies have stated the relevance of having new parameters to quantify the position and orientation of the scapula with patients standing upright. Although biplanar radiography can provide 3D reconstructions of the scapula and the spine, it is not yet possible to acquire these images with patients in the same position.

Methods: Two pairs of images were acquired, one for the 3D reconstruction of the spine and ribcage and one for the 3D reconstruction of the scapula.

3D reconstruction of the scapula from biplanar X-rays for pose estimation and morphological analysis.

Background: Patient-specific scapular shape in functional posture can be highly relevant to clinical research. Biplanar radiography is a relevant modality for that purpose with already two existing assessment methods. However, they are either time-consuming or lack accuracy.

Targeted exercises can improve biomechanical markers in individuals with knee osteoarthritis: A secondary analysis from a cluster randomized controlled trial.

Background: It is not clear whether exercise therapy significantly improves knee biomechanics during gait in osteoarthritis (OA) patients. This study aimed to determine whether targeted exercises based on a knee kinesiography exam improve biomechanical markers (BMs) compared with conventional primary care (CPC) management.

Methods: This was a secondary analysis of a cluster randomized controlled trial in which patients were assigned to one of three groups: (1) Control (CPC), (2) Exercise, and (3) Exercise&Education.

Biomechanical markers associations with pain, symptoms, and disability compared to radiographic severity in knee osteoarthritis patients: a secondary analysis from a cluster randomized controlled trial.

Background: Conventional radiography is commonly used to diagnose knee osteoarthritis (OA), but also to guide clinical decision-making, despite a well-established discordance between radiographic severity and patient symptoms. The incidence and progression of OA is driven, in part, by biomechanical markers. Therefore, these dynamic markers may be a good metric of functional status and actionable targets for clinicians when developing conservative treatment plans.

Multimodal data analysis of knee osteoarthritis assessment: factors selection for conservative care decision making.

When assessing a patient with knee osteoarthritis (OA), a number of factors are considered to guide treatment plan, namely, demographic, radiographic, clinical, musculoskeletal, and biomechanical factors. The aim of this study is to identify which of these factors are the most related to each other to potentially better prioritize the modifiable factors to be addressed as they may influence treatment outcomes. We investigated a multimodal canonical correlation analysis to evaluate associations between these factors.

Graphical-based multivariate analysis for knee joint clinical and kinematic data correlation assessment.

A large amount of data including joint kinematics, joint kinetics, clinical and functional measurements constitutes the clinical gait analysis basis which is a process whereby quantitative gait information are collected to aid in clinical decision-making. Therefore, better understanding the relationship between the biomechanical and clinical data for the knee osteoarthritis (OA) patient is for a relevant importance. It's the purpose of this paper, which aims to analyze and visualize the correlation structure between biomechanical characteristics and clinical symptoms, and thus to provide an additional knowledge from the coupling of these parameters that will be useful for the pathology assessment of knee-joint disease in the end-staged knee OA patients.

Morphologic and radiologic parameters correlating to shoulder function at diagnosis for patients with rotator cuff tear.

Background: The magnetic resonance imaging (MRI) parameters used to diagnose rotator cuff tears are weakly correlated to shoulder function. Our hypothesis was that adding 3-dimensional morphologic parameters resulting from biplanar radiographs (3DXR parameters) to the MRI parameters would improve this correlation.

Methods: We assessed 52 patients with rotator cuff tears with an EOS Imaging radiographic examination, MRI study, and clinical evaluation of the shoulder, as well as the Constant score.

Inertial motion capture validation of 3D knee kinematics at various gait speed on the treadmill with a double-pose calibration.

Background: Inertial motion capture (IMC) is rapidly gaining in popularity to evaluate gait in clinical settings. Previous examinations of IMC knee kinematics were often limited to the sagittal plane and IMC calibration has not been thoroughly investigated.

Research Question: The objective was to validate IMC 3D knee kinematics calibrated with a double-pose during gait with reference to optical motion capture (OMC).

A multi-arm cluster randomized clinical trial of the use of knee kinesiography in the management of osteoarthritis patients in a primary care setting.

: An important clinical gap reported by primary care physicians (PCPs) in managing knee osteoarthritis patients is the lack of validated tools to help them guide conservative treatment decision-making. This study aimed at evaluating the clinical utility of adding to current medical management (CMM) by PCPs, a dynamic knee kinesiography (KneeKG) exam assessing biomechanical risk factors linked to osteoarthritis progression.: In this 6-month cluster randomized controlled trial, primary care clinics were randomized into three groups: 1-CMM by PCPs, 2-CMM+KneeKG, and 3-CMM+KneeKG+Education (a self-management education session and two follow-up group meetings).

Hip-Knee-Ankle (HKA) angle modification during gait in healthy subjects.

Background: Achieving a neutral static Hip-Knee-Ankle angle (sHKA) measured on radiographs has been considered a factor of success for total knee arthroplasty (TKA). However, recent studies have shown that sHKA seems to have no effect on TKA survivorship. sHKA is not representative of the dynamic loading occurring during gait, unlike the dynamic HKA (dHKA).

A multivariate relationship between the kinematic and clinical parameters of knee osteoarthritis population.

Background: Biomechanical and clinical parameters contribute very closely to functional evaluations of the knee joint. To better understand knee osteoarthritis joint function, the association between a set of knee biomechanical data and a set of clinical parameters of an osteoarthritis population (OA) is investigated in this study.

Methods: The biomechanical data used here are a set of characteristics derived from 3D knee kinematic patterns: flexion/extension, abduction/adduction, and tibial internal/external rotation measurements, all determined during gait recording.

Can total knee arthroplasty restore the correlation between radiographic mechanical axis angle and dynamic coronal plane alignment during gait?

Background: Total knee arthroplasty (TKA) is the treatment of choice for end-stage knee osteoarthritis. Postoperative static knee alignment has been recognized as a key component of successful surgery. A correction toward the kinematics of a native knee is expected after TKA, with an aim for neutral mechanical alignment.

Quantification of joint alignment and stability during a single leg stance task in a knee osteoarthritis cohort.

Background: Knee osteoarthritis alters joint stability but its kinematics during functional weight-bearing tasks remain unclear. We propose and validate an assessment technique for the quantification of knee alignment and stability in patients during a short single leg stance task.

Methods: Three-dimensional knee kinematics were acquired non-invasively from 31 knee osteoarthritis patients (subdivided as moderate or severe) and 15 asymptomatic individuals during six short single-leg stance tasks.

Kinematic alignment in total knee arthroplasty better reproduces normal gait than mechanical alignment.

Purpose: Kinematic alignment technique for TKA aims to restore the individual knee anatomy and ligament tension, to restore native knee kinematics. The aim of this study was to compare parameters of kinematics during gait (knee flexion-extension, adduction-abduction, internal-external tibial rotation and walking speed) of TKA patients operated by either kinematic alignment or mechanical alignment technique with a group of healthy controls. The hypothesis was that the kinematic parameters of kinematically aligned TKAs would more closely resemble that of healthy controls than mechanically aligned TKAs.

Healthy 3D knee kinematics during gait: Differences between women and men, and correlation with x-ray alignment.

Background: Normal 3D knee kinematics during gait is still not well understood, especially regarding differences between women and men.

Research Question: The objective of the present study was to characterize 3D knee kinematics during gait in healthy women and men with a validated tool.

Methods: Knee kinematics was analysed with the KneeKG™ system in 90 healthy subjects (49 females and 41 males).

Rotator Cuff Tear Morphologic Parameters at Magnetic Resonance Imaging: Relationship With Muscle Atrophy and Fatty Infiltration and Patient-Reported Function and Health-Related Quality of Life.

Objective: The aim of this study was to determine the relationship between rotator cuff tear (RCT) morphologic parameters and muscle atrophy and fatty infiltration, and patient-reported outcome measures, in patients with symptomatic full-thickness RCT.

Methods: Rotator cuff tear location, length, width, thickness, and musculotendinous junction position were assessed in 57 magnetic resonance imaging scans and correlated to the outcome measures using multivariate regression analysis.

Results: Supraspinatus tendon tear length (odds ratio [OR], 2.

Comparison of soft tissue artifact and its effects on knee kinematics between non-obese and obese subjects performing a squatting activity recorded using an exoskeleton.

Background: Rigid attachment systems are one of the methods used to compensate for soft tissue artifact (STA) inherent in joint motion analyses.

Research Question: The goal of this study was to quantify STA of an exoskeleton design to reduce STA at the knee, and to assess the accuracy of 3D knee kinematics recorded with the exoskeleton in non-obese and obese subjects during quasi-static weight-bearing squatting activity using biplane radiography.

Methods: Nine non-obese and eight obese subjects were recruited.

Total knee arthroplasty with unexplained pain: new insights from kinematics.

Introduction: Up to 20% of total knee arthroplasty patients remain unsatisfied post-surgery, and a large proportion of them report anterior knee pain. This study aims to verify whether patients who experience anterior knee pain after total knee arthroplasty (TKA) will exhibit kinematic characteristics similar to those associated with patellofemoral syndrome, including in the frontal and transverse planes.

Materials And Methods: Using four different assessment methods [radiological, patient-reported outcome, musculoskeletal assessment with functional performance testing, and a 3D kinematic assessment during gait], the clinical and 3D knee kinematic profiles of three groups were compared: a painful and an asymptomatic TKA group and a healthy control group.

A multi-criteria evaluation platform for segmentation algorithms.

The purpose of this paper is to present a platform for evaluating segmentation algorithms that detect anatomical structures in medical images. Structure detection being subject to human interpretation, we first describe a method to define a ground truth model, i.e.

Tibio-femoral joint contact in healthy and osteoarthritic knees during quasi-static squat: A bi-planar X-ray analysis.

The aim of this study was to quantify the tibio-femoral contact point (CP) locations in healthy and osteoarthritic (OA) subjects during a weight-bearing squat using stand-alone biplanar X-ray images. Ten healthy and 9 severe OA subjects performed quasi-static squats. Bi-planar X-ray images were recorded at 0°, 15°, 30°, 45°, and 70° of knee flexion.

Mechanical biomarkers of medial compartment knee osteoarthritis diagnosis and severity grading: Discovery phase.

Objective: To investigate, as a discovery phase, if 3D knee kinematics assessment parameters can serve as mechanical biomarkers, more specifically as diagnostic biomarker and burden of disease biomarkers, as defined in the Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic classification scheme for osteoarthritis (OA) (Altman et al., 1986). These biomarkers consist of a set of biomechanical parameters discerned from 3D knee kinematic patterns, namely, flexion/extension, abduction/adduction, and tibial internal/external rotation measurements, during gait recording.

Effects of Prosthetic Mismatch and Subscapularis Tear on Glenohumeral Contact Patterns in Total Shoulder Arthroplasty: A Numerical Musculoskeletal Analysis.

Prosthetic components' mismatch and subscapularis (SC) tear are determining factors for glenoid failure complication in nonconforming total shoulder arthroplasty (NC-TSA). Risk factors are linked to glenoid prosthetic loading. However, the mechanisms underlying the clinical observations remain unclear.