Impact of the RxVaccinate program for pharmacy-based pneumococcal immunization: A cluster-randomized controlled trial.

Objectives: To evaluate the impact of the RxVaccinate program on the structure, process, and outcome measures and to assess team leaders' perceptions of the program.

Design: Cluster-randomized experimental design.

Setting: Community pharmacies.

Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases.

Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.

Self-assessment tool for screening patients at risk for drug therapy problems.

Objective: To describe the development, use, and evaluation of a patient self-assessment tool for screening patients at risk for drug therapy problems (DTPs) and potentially interested in receiving a personal consultation with a pharmacist.

Design: Quasi-experimental, nonrandomized, controlled study.

Setting: Area Agency on Aging-affiliated senior centers in Florida from April 2005 to December 2005.

Nisoldipine CC: clinical experience in ischaemic heart disease.

Nisoldipine coat core (CC) is a long-acting calcium channel blocker (CCB) with a slow and smooth onset of action. It is effective in the treatment of angina pectoris, increasing exercise duration, time to ST segment depression and time to onset of angina. The results of two studies reviewed here, in which patients received concomitant treatment with a beta-blocker, showed that the anti-anginal efficacy of nisoldipine CC, 40 mg once daily, measured at trough was comparable with amlodipine, 10 mg once daily, and with diltiazem retard, 120 mg twice daily, and that efficacy was maintained over a 24-hour period.

Gastric mucosal cell loss caused by aspirin and alcohol.

Gastric epithelial cell loss was studied in healthy volunteers before and after intragastric instillation of four aspirin (ASA) formulations and three strengths of alcohol. Each test solution was administered three times over a period of three hours during one of the experiments. Three of the four aspirin formulations significantly increased gastric epithelial cell loss.

[Campylobacter-like bacteria (C. pylori) in the healthy stomach?].

Unlabelled: Some authors recently published reports on the findings of unidentified S-shaped spiral bacteria, so called "Campylobacter pylori", in the gastric epithelium and the significant connection between these strains and gastric diseases. 24 fasting gastric juice samples of young healthy volunteers were now analysed bacteriologically using the campylobacter isolation techniques.

Results: It was not possible to find the so called "C.

Nitrate and nitrite in normal gastric juice. Precursors of the endogenous N-nitroso compound synthesis.

The nitrate and nitrite levels of 75 gastric juice samples from young and healthy fasting volunteers were examined. For both parameters a dependence on the specific pH value of the secretion was detected. The rise of the nitrite level from normal 0.

Video endoscopy. Fundamentals and problems.

The video system represents a new endoscopic technique with major advantages, some of which point the way into the future. This system permits a large number of persons to participate directly in the examination. Documentation is more comprehensive and more reliable, and pathological processes can be observed with the aid of video tape recordings.

[Bacterial colonization of the stomach caused by acid neutralization and inhibition of stomach emptying].

Gastric bacterial overgrowth was studied in 8 healthy volunteers. Total bacterial counts, nitrate-reducing bacteria and nitrite concentration were determined in fasting gastric juice before and after 4 weeks of treatment with a strong or with a mild antacid drug, a placebo preparation and the spasmolytic agent papaverine which is known to inhibit gastric evacuation. Placebo therapy and the mild antacid did not change any of the above parameters studied.

[Dynamics of endogenous bacterial nitrite formation in the stomach. 1. Follow-up studies in humans under natural conditions].

The fasting gastric secretion was analysed both bacteriologically and chemically in 15 young, voluntary test subjects with histories of a healthy stomach and physiological gastric secretion tests (Basal Acid Output, Peak Acid Output) made at regular intervals of two and 4 weeks over a period of three and six months. Two thirds of the persons studied showed during the entire period of examination the same pH values with tolerable variations and, as a result, the same order of magnitude for the total germ count, the colony count of the nitrite-forming bacteria and for the NO2- concentration. From this the conclusion can be drawn that, depending on the acidity of the individual stomach, there is an autonomous bacterial flora, which repeated examinations have shown to remain unaltered in quality and quantity.

[Endogenous synthesis of carcinogenic N-nitroso compounds: bacterial flora and nitrite formation in the healthy human stomach].

The endogenous synthesis of cancerogenic N-nitroso compounds: Bacterial flora and nitrite formation in the human stomach. In the discussion of the endogenous nitrosamine synthesis, nitrites play a decisive role. Since in a healthy stomach the acidity important for the nitrosamine formation is present, but since this acid environment is hostile to the bacterial growth and thus counteracts bacterial endogenous nitrite formation, the oral cavity has so far been regarded as the main site of endogenous nitrite formation.

[The combination preparation VisanoCor in patients with angina pectoris with special monitoring of urinary catecholamines].

In 18 patients with clinically confirmed arteriosclerosis, angina pectoris attacks and myocardial infarction, a distinct recession of catecholamines (adrenalin and noradrenalin were determined separately) was found in urine, also, a normalization of blood fat parameters. Frequency and intensity of angina pectoris attacks regressed. It is discussed that these effects might be explained by the special composition of VisanoCor.