Publications by authors named "Hagay Livne"
Article Synopsis
- Delivering large therapeutic proteins effectively across biological barriers like the blood-brain barrier is challenging, but Toxoplasma gondii, a parasite, shows promise in overcoming this issue by naturally moving from the gut to the central nervous system.
- Researchers have engineered T. gondii's secretion systems to facilitate the delivery of these proteins into neurons, testing their effectiveness in lab cultures, brain organoids, and living mice.
- The study specifically highlights the successful delivery of the MeCP2 protein, which could be a potential treatment for Rett syndrome, while also discussing the system's limitations and potential for future improvements.
Generation and characterization of a novel Knockout Model in Zebrafish.
Front Cell Dev Biol
October 2022
GNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human gene. encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis pathway. However, the process in which mutations lead to the development of a muscle pathology is not clear yet.
View Article and Find Full Text PDF