Publications by authors named "Hagai Marmor-Kollet"
Bloom's syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA secondary structures such as G-quadruplexes (G4s). However, its role in the regulation of cytoplasmic processes that involve RNA G-quadruplexes (rG4s) has not been previously studied. Here, we demonstrate that BLM is recruited to stress granules (SGs), which are cytoplasmic biomolecular condensates composed of RNAs and RNA-binding proteins.
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- - The study analyzes over 25,000 rare genetic variants in noncoding regions related to amyotrophic lateral sclerosis (ALS) using data from more than 6,000 ALS patients and over 70,000 controls.
- - Researchers found that specific variants in the 3' untranslated region of the IL18RAP gene are more common in non-ALS individuals, significantly lowering their risk of developing ALS by five times.
- - These IL18RAP variants enhance the survival of motor neurons by reducing neuroinflammation, highlighting the critical role of noncoding regions in genetic studies related to diseases like ALS.
Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs. Whereas much has been learned about SG formation, a major gap remains in understanding the compositional changes SGs undergo during normal disassembly and under disease conditions. Here, we address this gap by proteomic dissection of the SG temporal disassembly sequence using multi-bait APEX proximity proteomics.
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