Publications by authors named "Haft J"

Article Synopsis
  • - Of the 5 randomized controlled trials (RCTs) analyzed, 20% of participants had chronic thromboembolic pulmonary hypertension (CTEPH), but none specifically studied the impacts of exercise training in these patients.
  • - The study suggests that exercise training can enhance exercise capacity in pulmonary hypertension (PH) patients, specifically indicated by improvements in 6-minute walk distance.
  • - It also highlights that exercise training appears to be safe for patients with CTEPH and pulmonary arterial hypertension (PAH), challenging the common belief that exercise is risky for these individuals.
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Introduction:  Primary preventative medicine lacks a consensus on effective concussion prevention strategies for collegiate athletes. Cervical strength has been identified as a potential factor in concussion risk reduction. This study evaluates the impact of a commercially available, portable cervical muscle stretching and strengthening device, NeckX®, on cervical strength, range of motion (ROM), and concussion incidence in collegiate athletes participating in high-concussion-risk sports.

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Article Synopsis
  • Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension (CTEPH) faces challenges due to the need for safe devices to cross vascular lesions, prompting a study on the piercing properties of artery walls and CTEPH lesions.
  • In a lab experiment using specimens from nine patients, researchers measured the force required to penetrate artery walls and CTEPH lesions, finding that less force was needed for lesions compared to the arterial wall.
  • The study concluded that the arterial wall is delicate and can be damaged easily, but the lower force needed to cross CTEPH lesions suggests a potential safety margin for improving balloon pulmonary angioplasty procedures.
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  • Heart transplantation requires urgent procedures, as transplants must occur within 6 hours to avoid organ failure; traditionally, static cold storage (SCS) is the standard preservation method.
  • This study investigates the outcomes of piglet hearts preserved for extended periods (12 and 24 hours) using SCS, followed by a new warming technique called normothermic ex situ heart perfusion (NEHP).
  • Results show that hearts restored their function quickly after NEHP and were successfully transplanted, indicating that NEHP could improve the viability of hearts stored for long periods and potentially enhance transplant success rates.
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Article Synopsis
  • Catheter-based treatments are becoming important for both acute and chronic pulmonary blood clots, making it essential to understand the anatomy of pulmonary arterial branches.* -
  • A study of 179 patients undergoing angiography showed a variety of branching patterns in the pulmonary arteries, with a total of 7 patterns in the right upper lobe, 3 in the right middle lobe, and so on across the left lobes.* -
  • Notably, only 2-3 branching patterns per lobe were responsible for over 90% of the observed variations, offering valuable insights for medical professionals and future research in pulmonary interventions.*
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This year, we have again assembled an expert opinion on several key topics that pertain to the perioperative and critical care management of the cardiac surgery patient and for patients requiring extracorporeal membrane oxygenation. Approximately 1 in 3 patients undergoing cardiac surgery have diabetes mellitus; contemporary glycemic control management of these patients to minimize perioperative complications are reviewed. Goal directed fluid therapy remains an area on interest and controversy; the use of albumin as a resuscitation fluid and recent clinical trial data is reviewed.

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Objective: The technique for sternal closure has remained largely unchanged owing to the efficacy, simplicity, and low cost of stainless-steel sternal wires. Despite their ubiquity, several other closure devices designed to address the complications associated with sternal wires such as sternal bleeding and dehiscence have become popular. We have developed a novel sternal closure device that reduces sternal bleeding and dehiscence.

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The most common means of sternal closure after sternotomy is stainless steel wire cerclage. These wires, while inexpensive and simple in design, are known to be associated with low strength and sternal dehiscence. In this biomechanical analysis, we compare single sternal wires, double sternal wires, and a novel sternal closure device we have designed to mitigate sternal dehiscence.

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Background: Adult patients surviving with congenital heart disease (ACHD) is growing. We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-surgeries.

Methods: We reviewed the United Network for Organ Sharing-Standard Transplant Analysis and Research database and analyzed 35,952 heart transplants from January 1st, 2000, to September 30th, 2018.

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Background: Gastrointestinal bleeding (GIB) results in frequent hospitalizations and impairs quality of life in durable left ventricular assist device (LVAD) recipients. Anticipation of these events before implantation could have important implications for patient selection and management.

Methods: The study population included all adult HeartMate 3 (HM3) primary LVAD recipients enrolled in the STS Intermacs registry from January 2017 to December 2020.

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Estimating thresholds when a threshold effect exists has important applications in biomedical research. However, models/methods commonly used in the biomedical literature may lead to a biased estimate. For patients undergoing coronary artery bypass grafting (CABG), it is thought that exposure to low oxygen delivery (DO2) contributes to an increased risk of avoidable acute kidney injury.

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Extracorporeal membrane oxygenation (ECMO) is a type of extracorporeal life support (ECLS) in which the function of the heart and/or lungs is partially or completely replaced by a portable system that provides prolonged support to critically ill patients with respiratory or cardiac failure. There are two major variants of ECMO: veno-venous (VV) ECMO and veno-arterial (VA) ECMO. VV ECMO replaces the function of the lung in which it uses a cannula to remove venous blood and oxygenates it using the extracorporeal system, and returns the blood to the right atrium to be pumped to the body.

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Background: Persistent symptoms of chest pain, dyspnea, fatigue, lightheadedness, and/or syncope more than 3 months after an acute pulmonary embolism (PE) are collectively classified as postpulmonary embolism syndrome (PPES). Although PPES is increasingly recognized as an important long-term sequel of acute PE, its contemporary incidence is unclear. Furthermore, the utilization of diagnostic testing for further phenotypic characterization of these patients is unknown.

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Acute pulmonary embolism (PE) is a common cause of death and morbidity in the United States and the prevalence of chronic thromboembolic pulmonary hypertension (CTEPH), a possible sequela of PE, has increased during the past decade. The mainstay treatment of CTEPH is open pulmonary endarterectomy, a procedure performed under hypothermic circulatory arrest, which entails endarterectomy of the branch, segmental and subsegmental pulmonary arteries. Acute PE may be similarly be treated with an open embolectomy in certain select circumstances.

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Background: Balloon pulmonary angioplasty (BPA) was introduced as a treatment modality for patients with inoperable, medically refractory chronic thromboembolic pulmonary hypertension decades ago; however, reports of high rates of pulmonary vascular injury have led to considerable refinement in procedural technique.

Objectives: The authors sought to better understand the evolution of BPA procedure-related complications over time.

Methods: The authors conducted a systematic review of original articles published by pulmonary hypertension centers globally and performed a pooled cohort analysis of procedure-related outcomes with BPA.

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: The Extracorporeal Life Support Organization Supplies Platform (https://Supplies.ELSO.org) was created out of Extracorporeal Membrane Oxygenation (ECMO) disposable product shortage prior to and during the Coronavirus Disease 2019 (COVID-19) pandemic.

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Article Synopsis
  • After heart surgery, some patients end up staying in the ICU for a long time, which can lead to worse outcomes.
  • The study looked at over 8000 patients to see how long stays in the ICU affect survival rates and what factors might be linked to dying.
  • They found that the longer patients stayed in the ICU, the higher the chances were of them not surviving, with certain health issues like pneumonia making it worse.
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Background: Balloon pulmonary angioplasty (BPA) is currently performed at select centers worldwide, with the current standard of practice being postprocedural inpatient monitoring for 24 to 72 hours. We sought to evaluate the safety and efficacy of BPA in a cohort of patients with chronic thrombo-embolic pulmonary disease (CTEPD) and chronic thromboembolic pulmonary hypertension (CTEPH) and outline a protocol for implementation in the outpatient setting.

Methods: All patients with distal, inoperable CTEPH, residual symptoms after pulmonary endarterectomy, or symptomatic CTEPD from July 1, 2020, to June 30, 2022, were evaluated by a multidisciplinary chronic thromboembolic pulmonary hypertension team for consideration of BPA.

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Background: The Society of Thoracic Surgeons Workforce on Critical Care and the Extracorporeal Life Support Organization sought to identify how the coronavirus disease 2019 (COVID-19) pandemic has changed the practice of venoarterial (VA) and venovenous (VV) extracorporeal membrane oxygenation (ECMO) programs across North America.

Methods: A 26-question survey covering 6 categories (ECMO initiation, cannulation, management, anticoagulation, triage/protocols, and credentialing) was emailed to 276 North American Extracorporeal Life Support Organization centers. ECMO practices before and during the COVID-19 pandemic were compared.

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