The effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: a prospective case-control study.

Background: Every year, thousands of donors are exposed to granulocyte-colony stimulating factor (G-CSF) for stem cell mobilization in hematopoietic stem cell transplantations (HSCT). Previous studies about the genotoxicity of G-CSF were inconclusive. In this study, the genotoxic effects of G-CSF in peripheral blood stem cell (PBSC) donors were evaluated prospectively by using three different validated and reliable methods for the first time in the literature to the best of our knowledge.

Serum Basic Fibroblastic Growth Factor Levels in Children with Infantile Hemangioma.

Objectives: To determine serum levels of basic fibroblastic growth factor (b-FGF) in hemangioma patients under 2 y of age.

Methods: The study group consisted of 43 children with infantile hemangioma and b-FGF levels were analyzed using ELISA.

Results: The serum b-FGF levels were higher in hemangioma patients than in healthy control individuals (p 0.

An analysis of the levels of the soluble form of the endothelial protein C receptor in children with Henoch-Schönlein Purpura.

The pathogenesis of Henoch-Schönlein Purpura (HSP) has not been clearly defined. Inflammatory cytokines have been associated with HSP but there are only a few reports that have focused on coagulation. The endothelial protein C receptor (EPCR), which has anticoagulant and antiinflammatory activity, is the key component of the protein C pathway.

Serum soluble transferrin receptor is a valuable diagnostic tool in iron deficiency of breath-holding spells.

Iron-deficiency anemia may be a factor contributing to breath-holding spells. The serum transferrin receptor provides a useful measure of tissue iron deficiency. In this study of 50 breath-holders, while iron-deficiency anemia was detected in 28 (56%) of patients with routine tests, serum transferrin receptor levels were found increased in all patients.

Evaluation of erythropoiesis by serum transferrin receptor and ferritin in infants aged 0-6 months.

The aim of this study was to evaluate erythropoiesis in 198 healthy babies aged 0-6 months by determination of their blood count, serum transferrin receptor (STfR), and ferritin levels. Anemia and microcytosis were present in 9% and 13% of the sample, respectively. Microcytosis rate was as high as 45% in 6-month-old babies.

Effect of twice weekly versus daily iron treatment in Turkish children with iron deficiency anemia.

This study was designed to propose a more practical, effective, safer, inexpensive, and manageable alternative treatment of iron deficiency anemia (IDA) for the developing countries. The study involves 94 children between the ages of 5 months and 6 years who had been seen in the authors' hospital and diagnosed as having iron deficiency anemia. Ninety-four children with IDA were randomly divided into two groups: 48 children comprised the first group, which was administered conventional treatment, and 46 children comprised the second group, which was administered intermittent treatment involving iron administration 2 days a week.

Factor VIII levels in children with thrombosis.

Background: A number of coagulation defects have been implicated as risk factors in thrombo-embolic disease. Of these, high levels of clotting factor VIII have been shown to be associated with a five- to six-fold increased risk of thrombosis, compared to levels < 100 IU/dL in adults. The objective of this study was to investigate the prevalence of elevated plasma levels of factor VIII in a pediatric population with thrombo-embolism (TE).

High levels of FVIII and FIX in a pediatric patient with retinal artery occlusion.

A 13-year-old female patient with the diagnosis of retinal artery occlusion was evaluated for thrombophilia. The data revealed high FVIII and FIX levels. The patient had familial clustering.

Red blood cell indexes in patients in patients with hereditary spherocytosis and beta-thalassemia combination.

The spontaneous occurrence of hereditary spherocytosis (HS) and beta-thalassemia in the same patient is a rare event. The mean corpuscular hemoglobin concentration is elevated above the reference range in half to two-thirds of patients with HS, but there are no data for the HS/beta-thal combinations for the red blood cell indexes. This study reassessed these values in these particular patients.