Publications by authors named "Hafiz Muhammad Khalid"

Primary lymphoma of the central nervous system (PCNSL) is a rare and aggressive form of extranodal non-Hodgkin lymphoma primarily involving the brain, spinal cord, cerebrospinal fluid, and eyes. The role of surgical intervention in PCNSL is currently limited to biopsy and decompression of critical structures if needed - extended resection is debated. Chemotherapy is the mainstay of treatment.

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The understanding of brainstem gliomas and diffuse midline gliomas has significantly increased in the last decade. However, the management paradigm remains a dilemma. The critical location is the foremost factor dictating the outcome.

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This paper presents comprehensive consensus guidelines for the management of intracranial ependymoma, neoplasms arising from ependymal cells in the central nervous system's ventricular system, in low- and middleincome countries (LMICs). Acknowledging the distinct epidemiological patterns of ependymomas, notably their higher incidence in paediatric patients, and variable survival rates, these guidelines emphasize tailored management approaches for different age groups. An expert panel, comprising specialists in neuro-oncology, convened to address gaps in diagnosis and management within LMICs, considering the varying clinical presentation based on tumour size and location.

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Article Synopsis
  • Craniopharyngiomas are non-cancerous tumors linked to the pituitary gland, causing challenges due to their location near vital brain structures like the hypothalamus and optic nerves.
  • Surgical removal is the main treatment, but complications like recurrence and visual problems are more common in low- and middle-income countries (LMICs) due to factors like late diagnosis and lack of resources.
  • The manuscript offers management guidelines for LMICs, suggesting a mix of surgery and chemoradiation for better patient outcomes, ideally overseen by a specialized neuro-oncology team.
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