Pharmacological Assessment of Aqueous Ethanolic Extract of Against Haloperidol-Induced Parkinson's Like Symptoms in Animal Model: A Dose-Dependent Study With Mechanistic Approach.

Parkinson's disease (PD) is characterized by dopamine deficiency in the corpus striatum due to the degeneration of dopaminergic neurons in the substantia nigra. Symptoms include bradykinesia, resting tremors, unstable posture, muscular rigidity, and a shuffled gait. is traditionally used for neurodegenerative disorders.

Effects of long-term extract supplementation on fear, cognition and brain antioxidant levels.

Introduction: is an indigenous plant known for various remedial properties. The present study aimed to evaluate the neuroprotective potential of methanolic extract (AA) bark as current scientific trend is searching plant for neurodegenerative diseases, worldwide.

Methodology: In experiments, the AA was analyzed for phenols, flavonoids, antioxidative and cholinesterase inhibitory properties with subsequent detailed characterization for secondary metabolites.

Improved solubility and corneal permeation of PEGylated curcumin complex used for the treatment of ophthalmic bacterial infections.

Naturally occurring curcumin can be used for the treatment of corneal bacterial infections with its limitation of poor solubility. Aim of the present study was to enhance solubility and permeation of curcumin for the treatment of corneal bacterial infections. For increasing solubility, curcumin and polyethylene glycol (PEG 6000) complex (1:3) was prepared by fusion melting method.

Chemical characterization and evaluation of the neuroprotective potential of studies and behavioral tests in scopolamine-induced memory compromised rats.

In the current study, we investigated the phytochemical and neuropharmacological potential of , an indigenous least characterized plant widely distributed in deserted areas of Pakistan. The crude extract of the whole plant (IS.CR) was preliminary tested for the existence of polyphenol content, antioxidant and anticholinesterase potential followed by detailed chemical characterization through UHPLC-MS.

Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies.

In the current research work, a facile synthesis of a series of novel thiophene-based derivatives of 5-bromothiophene-2-carboxylic acid ( ) have been synthesized. All analogs ( - , - ) were obtained from the coupling reaction of 5-bromothiophene-2-carboxylic acid ( ) and different arylboronic acids with moderate-to-good yields under controlled and optimal conditions. The structures of the newly synthesized compounds were characterized through spectral analysis and their spasmolytic activity, and most of the compounds exhibited potentially good spasmolytic effect.

Pharmacological Modulation of Smooth Muscles and Platelet Aggregation by .

Traditionally, in the Southern Asian countries, is a widely used plant for the management of various ailments such as gastrointestinal, respiratory, and cardiac disorders, but it lacks proof on a scientific basis, and therefore, this is the major emphasis of the current research work. Crude extract of (Pc.Cr) was preliminary analyzed for the presence of different classes of bioactive molecules.

Development and validation of an economical uric acid-Fe/Fe-ferrozine-based colorimetric assay to estimate uric acid level of pure and biological samples.

This work presents the development and validation of a simple, rapid, and cost-effective spectrophotometric method for quantitative analysis of uric acid in biological samples. The method relies upon uric acid-led reduction of Fe(III) to Fe(II) of sample/standard solutions which stoichiometrically engages ferrozine to form a magenta-colored complex. Different parameters including pH, metal and chelator concentrations, temperature, etc.

Pharmacological Studies Pertaining to Smooth Muscle Relaxant, Platelet Aggregation Inhibitory and Hypotensive Effects of .

Objective: This in vitro and in vivo study was conducted to rationalize some of traditional medicinal uses of in gastrointestinal, respiratory, and cardiovascular systems.

Materials: Crude extract of (Aa.Cr) and its fractions were prepared and utilized in in vitro and in vivo studies.

Pharmacological evaluation of smooth muscle relaxant and cardiac-modulation potential of Phyla nodiflora in ex-vivo and in-vivo experiments.

Objective: To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation.

Methods: The crude hydroalcoholic extract of P.

Pharmacological Evaluation of Gut Modulatory and Bronchodilator Activities of Achyranthes aspera Linn.

Achyranthes aspera L. is traditionally used to relieve constipation, diarrhea, and asthma. Its crude extract (Aa.

Calcium channel blocking activity in Desmostachya bipinnata (L.) explains its use in gut and airways disorders.

Desmostachya bipinnata, despite of its popular medicinal uses, has not been widely studied for its effect in diarrhea, indigestion, and asthma. The aim of the present investigation was to provide scientific rationale for these applications. The crude aqueous-methanolic extract of D.