Comparing Different Methods for the Diagnosis of Liver Steatosis: What Are the Best Diagnostic Tools?

Background: Due to the ongoing organ shortage, marginal grafts with steatosis are more frequently used in liver transplantation, leading to higher occurrences of graft dysfunction. A histological analysis is the gold standard for the quantification of liver steatosis (LS), but has its drawbacks: it is an invasive method that varies from one pathologist to another and is not available in every hospital at the time of organ procurement. This study aimed to compare non-invasive diagnostic tools to a histological analysis for the quantification of liver steatosis.

In Vivo Feasibility of Arterial Embolization with a New Permanent Agar-agar-Based Agent.

Purpose: Evaluate the safety and efficacy of an eco-friendly permanent agar-agar-based embolization agent (ABEA) (EmboBio®) for intra-arterial use.

Materials And Methods: Six pigs embolized with one ABEA torpedo (6 lower polar renal and 6 lumbar arteries) and one coil (6 lower polar renal and 6 lumbar arteries). Technical success was defined as a complete occlusion with no residual flow in DSA.

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control.

MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expression in normal/healthy tissues, making them attractive targets for therapeutic intervention. We have generated a series of anti-MICA and MICB cross-reactive antibodies with the unique feature of binding to the most prevalent isoforms of both these molecules.

[BRAF mutation evolution in melanoma: Myth or reality?].

Knowledge of the BRAF mutational status has become essential for melanoma therapeutic management. B-Raf inhibitors are associated with significant overall survival in patients with BRAFV600-mutated metastatic melanoma. Although the BRAF mutation appears to be an early and driver mutation, some authors hypothesized that its expression was not stable during melanoma progression, suggesting a molecular heterogeneity.

Supertetrahedral anions in the phosphidosilicates NaBaSiP and NaBaSiP.

Solid ionic conductors are one key component of all-solid-state batteries, and recent studies with lithium, sodium and potassium phosphidosilicates revealed remarkable ion conduction capabilities in these compounds. We report the synthesis and crystal structures of two quaternary phosphidosilicates with sodium and barium, which crystallize in new structure types. Na1.

NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms.

YAP1-NUTM1 fusion transcripts have been recently reported in poroma and porocarcinoma. NUTM1 translocation can be screened by nuclear protein in testis (NUT) immunohistochemistry in various malignancies, but its diagnostic performance has not been thoroughly validated on a large cohort of cutaneous epithelial neoplasms. We have evaluated NUT immunohistochemical expression in a large cohort encompassing 835 cases of various cutaneous epidermal or adnexal epithelial neoplasms.

Polymorphism and Fast Potassium-Ion Conduction in the T5 Supertetrahedral Phosphidosilicate KSi P.

The all-solid-state battery (ASSB) is a promising candidate for electrochemical energy storage. In view of the limited availability of lithium, however, alternative systems based on earth-abundant and inexpensive elements are urgently sought. Besides well-studied sodium compounds, potassium-based systems offer the advantage of low cost and a large electrochemical window, but are hardly explored.

Preparation of iron(IV) nitridoferrate CaFeN through azide-mediated oxidation under high-pressure conditions.

Transition metal nitrides are an important class of materials with applications as abrasives, semiconductors, superconductors, Li-ion conductors, and thermoelectrics. However, high oxidation states are difficult to attain as the oxidative potential of dinitrogen is limited by its high thermodynamic stability and chemical inertness. Here we present a versatile synthesis route using azide-mediated oxidation under pressure that is used to prepare the highly oxidised ternary nitride CaFeN containing Fe ions.

Combination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model.

Objective: To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)-Alco-Squid 18-in a swine model.

Materials And Methods: Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. An arteriovenous malformation (AVM) model was created in group 1 ( = 2).

[Point of view: A lesson from lockdown, histopathology through videoconferencing].

The use of videoconferencing had increased significantly during lockdown. During this period, videoconferencing has been used in the pathological department of pathology (Timone university hospital, Marseille, France) for academic, diagnosis and referral. We provide our point of view regarding the use of this tool.

Genetic variant of SRF-rearranged myofibroma with a misleading nuclear expression of STAT6 and STAT6 involvement as 3' fusion partner.

Pediatric neoplasms with a myofibroblastic differentiation are frequent in children, in particular myofibroma. Recently, a novel deep soft tissue myofibroblastic neoplasm has been described with high cellularity, a smooth muscle phenotype and SRF-RELA fusion. We report the case of a 15-year-old boy who presented with a tumor of the deep soft tissue of the arm, with overlapping histological features with the recently described SRF-RELA group of myofibromas but differing by the presence of calcifications, a novel SRF-STAT6 fusion transcript and nuclear expression of STAT6.

Supertetrahedral Layers Based on GaAs or InAs.

The solid-state compounds As and GaAs ( = Sr, Eu; = Ga, In) were synthesized by heating the elements, and their crystal structures were determined by single-crystal and powder X-ray diffraction (space group 2/). The structures are hierarchical variants of the HgI type and consist of layers of polymeric T5 (As) or T6 supertetrahedra (GaAs), separated by strontium or europium cations. These compounds constitute hitherto unknown GaAs- or InAs-based supertetrahedral structures and represent the first binary vacancy-free T5 and T6 supertetrahedra.

In Vivo Feasibility of Arterial Embolization with Permanent and Absorbable Suture: The FAIR-Embo Concept.

Purpose: Arterial embolization has been shown to be effective and safe for the management of bleeding, especially for postpartum and pelvic traumatic bleeding. We propose to evaluate the proof of concept of feasibility and effectiveness of arterial embolization with absorbable and non-absorbable sutures in a porcine model.

Materials And Methods: In the acute setting (n = 1), several different arteries (mesenteric, splenic, pharyngeal, kidney) were embolized using non-absorbable sutures (NAS): Mersutures™ braided sutures (polyethylene terephthalate).

Density-dependent determination of scattering properties of pharmaceutical tablets using coherent backscattering spectroscopy.

We report on measurements of coherent backscattering from pharmaceutical tablets. Experimental data is analysed using the radiative transfer equation with focus on the determination of the reduced scattering coefficient μs'. The results show a good agreement with μs' determined by measuring the spatially resolved reflectance, whereat we demonstrate advantages of the coherent backscattering measurements.

Fast Sodium-Ion Conductivity in Supertetrahedral Phosphidosilicates.

Fast sodium-ion conductors are key components of Na-based all-solid-state batteries which hold promise for large-scale storage of electrical power. We report the synthesis, crystal-structure determination, and Na -ion conductivities of six new Na-ion conductors, the phosphidosilicates Na Si P , Na Si P , Na Si P , Na Si P , LT-NaSi P and HT-NaSi P , based entirely on earth-abundant elements. They have SiP tetrahedra assembled interpenetrating networks of T3 to T5 supertetrahedral clusters and can be hierarchically assigned to sphalerite- or diamond-type structures.

Supertetrahedral Networks and Lithium-Ion Mobility in Li SiP and LiSi P.

The new phosphidosilicates Li SiP and LiSi P were synthesized by heating the elements at 1123 K and characterized by single-crystal X-ray diffraction. Li SiP (I4 /acd, Z=32, a=12.111(1) Å, c=18.

[Perianal dermatoses].

Perinatal skin disease present a frequent problem in clinical practise. Their treatment confronts different medical specialties. For the sake of modesty, it often takes a long time until patients seek medical attention.

The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapy.

Background: Epicutaneous vaccination has gained increasing interest during the past decade as it offers a safe, needle-free, and patient-friendly alternative to invasive vaccine administrations. Recently, the safety and early efficacy of epicutaneous immunotherapy were also demonstrated in patients with hay fever, as an alternative to conventional subcutaneous allergen-specific immunotherapy (SCIT). One major challenge to epicutaneous vaccination is the barrier function of the stratum corneum, which must be overcome either by abrasive methods or by hydration.