Publications by authors named "Hafees O Ajibola"
Article Synopsis
- Men of African descent experience the highest rates of prostate cancer, but the genetic factors behind this have not been thoroughly explored.
- Researchers analyzed genetic data from nearly 4,000 prostate cancer cases and over 3,500 controls across several African countries to identify specific genetic associations related to the disease.
- The study found 15 significant genetic associations, including four new ones, highlighting that genetic variation in prostate cancer is influenced by unique African alleles, suggesting that more research in diverse populations is crucial for understanding cancer genetics.
Article Synopsis
- A recent study analyzed genetic data from over 156,000 prostate cancer cases and 788,000 controls from diverse populations, significantly increasing the representation of non-European participants.
- Researchers identified 187 new genetic risk variants for prostate cancer, bringing the total to 451, enhancing understanding of genetic factors across different ancestries.
- The developed genetic risk score (GRS) showed varying risk levels for prostate cancer among different ancestry groups, highlighting its potential for better risk assessment, especially in men of African descent.
Background: Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective: To discover common genetic variants contributing to the risk of PCa in men of African ancestry.
Design, Setting, And Participants: We conducted a meta-analysis of ten genome-wide association studies consisting of 19378 cases and 61620 controls of African ancestry.
Fixed drug eruptions (FDE) are typically associated with residual hyperpigmentation or non-pigmenting lesions. There is no distinctive histopathological feature; though, drug provocation tests (DPT) can be confirmatory within 7 days. We describe a patient with penile FDE associated with residual hypopigmentation, a prolonged refractory period to DPT and recurrent meatal stenosis.
View Article and Find Full Text PDFBackground: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we evaluated test characteristics of PRS from three previous studies using data from the UK Biobank and a novel dataset of 1298 prostate cancer cases and 1333 controls from Ghana, Nigeria, Senegal, and South Africa.
View Article and Find Full Text PDFBackground: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and additional independent studies.
Methods: Within each ancestry population, the association of PRS with prostate cancer risk was evaluated separately in each case-control study and then combined in a fixed-effects inverse-variance-weighted meta-analysis.