Publications by authors named "Haeun Ko"
Article Synopsis
- Intestinal bacteria (microbiota) are shown to influence the function of regulatory T (Treg) cells in the colon, but the specifics of this interaction were previously unclear.
- This study utilizes advanced techniques to analyze Tregs from both standard mice and germ-free mice, revealing that microbiota influences the development of specific Treg types.
- The findings highlight a new interaction between gut microbiota and immune cells, suggesting potential therapeutic approaches for treating intestinal inflammatory diseases.
Article Synopsis
- - Innate immune cells play a crucial role in fighting tumors, and their function can be influenced by beneficial bacteria found in food.
- - The specific bacterial strain Lactiplantibacillus plantarum IMB19 enhances antitumor immunity in mouse models, primarily through its capsular heteropolysaccharide, which activates immune pathways.
- - This strain reprograms tumor-related macrophages to promote robust T cell responses while also capturing iron in the tumor environment, potentially leading to cancer cell death and improved treatment strategies using "oncobiotics."
Article Synopsis
- - The gut microbiota composition affects the immune system and is linked to diseases like allergies and inflammation; however, more research is needed on microbial therapies.
- - The study compared the bacterial consortium MPRO (HY7712, HY8002, HY2782) with its individual strains, finding that MPRO was more effective in treating atopic dermatitis and inflammatory colitis.
- - Administration of MPRO reduced inflammation and changed the gut microbiome, resulting in increased immune cells that help suppress inflammation, suggesting that combined bacterial treatments may be more beneficial than single strains.
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. A complex interaction of environmental and genetic factors leads to the disruption of immune tolerance towards self, causing overt immune activation and production of autoantibodies that attack multiple organs. Kidney damage, termed lupus nephritis, is the leading cause of SLE-related morbidity and mortality.
View Article and Find Full Text PDFHypoxia, or low oxygen tension, is a hallmark of the tumor microenvironment. The hypoxia-inducible factor-1α (HIF-1α) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance. Phosphorylation is involved in the stabilization and regulation of HIF-1α transcriptional activity.
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