Publications by authors named "Haejin An"
Serum response factor (SRF) is a master transcription factor that regulates immediate early genes and cytoskeletal remodeling genes. Despite its importance, the mechanisms through which SRF stably associates with its cognate promoter remain unknown. Our biochemical and protein-induced fluorescence enhancement analyses showed that the binding of SRF to serum response element was significantly increased by inositol polyphosphate multikinase (IPMK), an SRF cofactor.
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- Spt5 is a key transcription factor that influences various stages of gene expression, from initiation to termination.
- Recent findings indicate that mutations in Spt5 lead to increased antisense transcripts near promoters, suggesting a complex regulatory role.
- Spt5p maintains the balance of transcription by suppressing undesired antisense transcription through modifications like histone acetylation and interacting with termination factors, which is crucial for proper RNA polymerase II function.