Publications by authors named "Hae-Soo Lee"
Drug Deliv Transl Res
May 2023
Article Synopsis
- Ticagrelor (TCG) is a poorly soluble and permeable antiplatelet drug, leading to research on drug delivery improvements.
- A high-loaded nanostructured lipid carrier (HL-NLC) for TCG was created, resulting in an optimized particle size and high encapsulation efficiency.
- The final product, an S-HL-NLC tablet, showed significant improvement in bioavailability compared to raw TCG, with over 90% drug release in 24 hours and no cytotoxicity in tests.
Pharmaceutics
January 2021
Article Synopsis
- - The synthesis of mesoporous silica nanoparticles (MSNs) using the Box-Behnken design focused on optimizing variables like CTAB, TEOS, and NaOH to improve their physicochemical properties.
- - The generated MSNs, with specific reagent amounts, exhibited favorable characteristics and demonstrated low toxicity when tested on MCF-7 cancer cells.
- - MSN@DOX, the version loaded with doxorubicin, showed effective drug release that increased with lower pH levels and sustained for 48 hours, confirming its potential as a drug delivery system.
