Evaluation of linear regression statistical approaches for withdrawal time estimation of veterinary drugs.

The safety of foods of animal origin requires the determination of the time at which veterinary drug residues in edible tissues are below a given maximum residue limit (MRL). For this reason, a certain withdrawal time estimate is determined for drugs based on statistical evaluation of concentrations determined by analytical analysis of residues in target organs of healthy animals. The purposes of this paper is to evaluate the linear regression statistical approach for the estimation of withdrawal time of veterinary drugs as recommended by Food and Drug Administration (FDA) and European Union/Committee for Medicinal Products for Veterinary use (EU/CVMP) and compare the application with a real model example.