Publications by authors named "Hae Ryoun Park"

Purpose: To evaluate the effects of fucosterol and fucoxanthin on ultimate microtensile strength (µUTS), dentin collagen cross-linking, erosion resistance, and matrix metalloproteinase (MMP) inhibition.

Methods: Dentin beams and slices were prepared from extracted human teeth and treated with concentrations of 50 µg/mL, 100 µg/mL, and 200 µg/mL of fucosterol and fucoxanthin. Fourier-transform infrared spectroscopy (FTIR) was used to analyze collagen cross-linking.

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Fucosterols have been widely studied for their antioxidant, anticancer, and anti-inflammatory properties. However, they have not yet been studied in the field of dentistry. This study aimed to determine whether pretreatment of dentin with fucosterol before resin restoration enhances bond stability in resin-dentin hybrid layers.

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Objective: Porphyromonas gingivalis (P. gingivalis), one of the major periodontopathogens, is associated with the progression and exacerbation of atherosclerosis. In this study, we aimed to investigate whether the gastrin-releasing peptide receptor antagonist, RC-3095, could attenuate P.

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Article Synopsis
  • Type 2 diabetes mellitus (T2DM) and periodontitis (PD) are linked as chronic inflammatory diseases, but their exact connection is not fully understood.
  • Researchers used a multiomics approach to study genetic and epigenetic changes in the tissues of PD patients with and without diabetes, finding common alterations between the two groups.
  • Their results indicate that targeting the Fc-gamma receptor-mediated phagocytosis pathway in monocytes may offer a new treatment strategy for managing complications related to diabetes.
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Objectives: This study aimed to screen oral squamous cell carcinoma (OSCC) diagnostic and prognostic candidates and investigate the potential functions and mechanisms of candidates in the chemoresistance of OSCC cell lines.

Materials And Methods: Differential expression profiling of lncRNA was performed in a large cohort of OSCC patients from the Cancer Genome Atlas database to identify OSCC diagnostic and prognostic candidates. Taxol resistance in OSCC cell lines was analyzed using MTT assay.

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Human papillomavirus (HPV) is a major causative factor of head and neck squamous cell carcinoma (HNSCC), and the incidence of HPV associated HNSCC is increasing. The role of tumor microenvironment in viral infection and metastasis needs to be explored further. We studied the molecular characteristics of primary tumors (PTs) and lymph node metastatic tumors (LNMTs) by stratifying them based on their HPV status.

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Article Synopsis
  • The study investigates the complex relationship between type 2 diabetes mellitus (DM) and periodontitis (PD) to understand their immunological connections better.
  • Researchers analyzed blood samples from healthy individuals, PD patients without DM, and those with both conditions using single-cell RNA sequencing.
  • Findings revealed that DM negatively impacts immune cell function and introduces pro-inflammatory changes, particularly highlighting the role of RESISTIN in increasing diabetes susceptibility, suggesting a significant immunological link between PD and DM.
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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes cartilage and bone damage. Exosomes are small extracellular vesicles that play a critical role in intercellular communication and various biological processes by serving as vehicles for the transfer of diverse molecules, such as nucleic acids, proteins, and lipids, between cells. The purpose of this study was to develop potential biomarkers for RA in peripheral blood by performing small non-coding RNA (sncRNA) sequencing using circulating exosomes from healthy controls and patients with RA.

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Article Synopsis
  • Blood platelets are important for understanding cardiovascular disease risks, especially in patients with periodontitis and type 2 diabetes mellitus (DM), but research on this interaction is limited.
  • In a study, researchers used single-cell RNA sequencing to analyze platelet gene expression in healthy individuals, those with periodontitis, and those with both periodontitis and DM.
  • The findings indicated that while both patient groups showed increased platelet activation, those with periodontitis and DM had altered gene expressions related to stress response and oxidative processes, suggesting a disruption in normal platelet function.*
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The WAVE regulatory complex (WRC) is involved in various cellular processes by regulating actin polymerization. The dysregulation of WRC components is associated with cancer development. ABI family member 3 (ABI3)/new molecule including SH3 (NESH) is one of the WRC components and it has been reported that ABI3 phosphorylation can affect WRC function.

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Purpose: The aim of this study was to investigate the relationship between serum uric acid (SUA) levels and the risk of periodontitis in Korean adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES).

Methods: This cross-sectional study used data from the KNHANES 2016-2018 and analysed 12,735 Korean adults aged ≥19 years who underwent oral examinations. Hypouricemia was defined as SUA <3 mg/dL in men and <2 mg/dL in women, and hyperuricemia was defined as SUA ≥7 mg/dL in men and ≥6 mg/dL in women.

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The homing of M1 and M2 macrophages may play distinct roles in the tumor microenvironment (TME). However, these roles of macrophages in the TME remain unclear. We downloaded RNA sequencing data from The Cancer Genome Atlas (TCGA) database for patients with CRC.

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Deep learning methods are powerful analytical tools for large-scale data analysis. Here, we introduce DeepCIA as a novel diagnostic deep-learning model for cancer type identification using a class activation map via transcription factor expression. Although many deep learning researches attempts have recently been made in relation to cancer diagnosis, there are difficulties in using cancer data due to a large-scale problem.

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Periodontitis and diabetes mellitus (DM) have a bidirectional relationship. Periodontitis is initiated by dysbiosis of oral microorganisms, and in particular, the characteristics of the microorganisms that have penetrated the tissue are directly related to the disease; therefore, we investigated the effect of DM on intragingival microbial profiling of patients with periodontitis. A total of 39 subjects were recruited and divided into three groups in this case control study as follows: healthy (NA, 10), periodontitis only (PD, 18), and periodontitis with DM (PD_DM, 11).

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Growing evidence suggests that genetic and epigenetic factors, including environmental factors, contribute to the development of oral squamous cell carcinoma (OSCC). Here, we investigated the transcriptional silencing of the CD24, CD44, CD133, and CD147 genes, which are well-known cancer stem cell surface markers in various cancer types, including OSCC. We first examined the correlation between the transcriptional expression level and reactivation by 5-aza-2′-deoxycytidine (5-aza-dC) and the promoter methylation levels of the four genes in several OSCC cell lines.

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Background: Periodontitis is a major inflammatory disease of the oral mucosa that is not limited to the oral cavity but also has systemic consequences. Although the importance of chronic periodontitis has been emphasized, the systemic immune response induced by periodontitis and its therapeutic effects remain elusive. Here, we report the transcriptomes of peripheral blood mononuclear cells (PBMCs) from patients with periodontitis.

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Background: Several studies have demonstrated association between coffee consumption and periodontal diseases. However, no systematic review and meta-analysis was performed. Therefore, we performed a systematic review and meta-analysis to evaluate the association between coffee intake and periodontitis.

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Purpose: We retrospectively analysed patients' dental and periodontal status according to the presence of non-communicable diseases (NCDs) and the effects of NCDs on periodontal treatment outcomes. Factors influencing disease recurrence were investigated using decision tree analysis.

Methods: We analysed the records of patients who visited the Department of Periodontology, Pusan National University Dental Hospital from June 2014 to October 2019.

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Background: Microbiome has been shown to substantially contribute to some cancers. However, the diagnostic implications of microbiome in head and neck squamous cell carcinoma (HNSCC) remain unknown.

Methods: To identify the molecular difference in the microbiome of oral and non-oral HNSCC, primary data was downloaded from the Kraken-TCGA dataset.

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Article Synopsis
  • - The text discusses the bidirectional relationship between type 2 diabetes and periodontitis, highlighting the importance of understanding common genetic factors for better treatment strategies.
  • - Researchers analyzed gene expression data, identifying 152 differentially expressed genes (DEGs) that were linked to both diseases, focusing on genes involved in the Fc gamma receptor-mediated phagocytosis pathway.
  • - Three specific up-regulated hub genes were pinpointed as potential therapeutic targets for treating individuals suffering from both periodontitis and type 2 diabetes.
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Objective: This study aimed to profile differentially expressed (DE) exosomal RNAs in healthy subjects and periodontitis patients and compare their levels before and after treatment.

Materials And Methods: Plasma samples from healthy subjects and patients with periodontitis (pre-/post-periodontal treatment) were collected for this case-control study. After isolation of exosomes from the plasma, the RNA was extracted and small RNA sequencing was performed (3 healthy samples, 4 pre-treatment samples, and 5 post-treatment samples).

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To investigate whether dental status, represented by the DMFT score, was affected by the presence of NCDs and determined the NCDs that had a greater impact on the DMFT score. This retrospective cross-sectional study included a total of 10,017 individuals. The presence of NCDs was investigated based on self-reported medical history recorded on each patient's dental hospital record.

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Article Synopsis
  • Oral lichen planus (OLP) is a common oral mucosal disease without a current cure, and this study aimed to understand its development by analyzing gene expression data.
  • The analysis revealed that genes associated with skin development, immune responses, and inflammation were significantly altered in OLP tissue compared to healthy tissue.
  • A specific protein, IL-36γ, showed increased expression in OLP and may represent a potential target for future treatments focusing on healing and immune defense.
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Non-coding microRNAs (miRNAs) have been proposed to play diverse roles in cancer biology, including epithelial-mesenchymal transition (EMT) crucial for cancer progression. Previous comparative studies revealed distinct expression profiles of miRNAs relevant to tumorigenesis and progression of oral cancer. With putative targets of these miRNAs mostly validated , it remains unclear whether similar miRNA-target relationships exist .

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