The aim of this study was to investigate expression of cyclin D1, bcl-2, p53, Ki-67 and HER-2 proteins in 14 cases of non-small cell lung cancer and to establish their correlation to classical clinico-pathological findings, and alleged prognostic value to estimate biological potential of tumor. Retrospective pilot study of the surgically treated non-small cell lung cancer biopsy specimen, paraffin embedded, used immunohistochemical method to demonstrate expression of cyclin D1, bcl-2, p53, Ki-67 and HER-2. Protein quantification was performed by the semi-quantitative method.
View Article and Find Full Text PDFPenetrating chest injuries are the most frequent causes of serious demage and death in wounded indivisuals. In reports from the last wars where wounds caused by high velocity projectiles predominated, thoracotomies were perfomed in about 15% of the wounded individuals, mostly encompassing injuries of the heart and great vessels, accomanied by massive bleeding that could not be resolved by chest tube insertion. This retrospective analysis was performed on the medical records of 477 patients tretaed for isolated penetrating chest injuries in Department of Thoracic Surgery Clinical Center of the University in Sarajevo between april 1992 - june 1995.
View Article and Find Full Text PDFRole and importance of the explorative thoracotomy in diagnostics of malignant neoplasmas of the lung have great value. Among other diagnostic procedures explorative thoracotomy has an advantage because of visualization of process and possibility of the biopsy "extempore". As each diagnostic procedure, explorative thoracotomy has its own deficiencies because the procedure is aggressive, related to possibility of the postoperative complications, and because of these problems explorative thoracotomy is ultimative method in diagnosis of malignant neoplasmas of the lungs.
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