Search for new physics in events with a leptonically decaying Z boson and a large transverse momentum imbalance in proton-proton collisions at = 13 .

A search for new physics in events with a Z boson produced in association with large missing transverse momentum at the LHC is presented. The search is based on the 2016 data sample of proton-proton collisions recorded with the CMS experiment at , corresponding to an integrated luminosity of 35.9 .

Search for new physics in dijet angular distributions using proton-proton collisions at and constraints on dark matter and other models.

A search is presented for physics beyond the standard model, based on measurements of dijet angular distributions in proton-proton collisions at . The data collected with the CMS detector at the LHC correspond to an integrated luminosity of 35.9 .

Measurement of the cross section in pp collisions at and validation of lepton analysis techniques.

A measurement is presented of the cross section in collisions at , using data recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of . The product of the inclusive cross section and branching fraction is measured to be , in agreement with the standard model expectation, computed at next-to-next-to-leading order accuracy in perturbative quantum chromodynamics. The measurement is used to validate new analysis techniques relevant for future measurements of lepton production.

Measurement of prompt and nonprompt charmonium suppression in collisions at 5.02 .

The nuclear modification factors of and mesons are measured in collisions at a centre-of-mass energy per nucleon pair of . The analysis is based on and data samples collected by CMS at the LHC in 2015, corresponding to integrated luminosities of 464 and 28 , respectively. The measurements are performed in the dimuon rapidity range of as a function of centrality, rapidity, and transverse momentum ( ) from in the most forward region and up to 50 .

Measurement of b hadron lifetimes in pp collisions at .

Measurements are presented of the lifetimes of the , , , and hadrons using the decay channels , , , , , and . The data sample, corresponding to an integrated luminosity of 19.7 , was collected by the CMS detector at the LHC in proton-proton collisions at .

Measurement of differential cross sections for boson production in association with jets in proton-proton collisions at .

The production of a boson, decaying to two charged leptons, in association with jets in proton-proton collisions at a centre-of-mass energy of 13 is measured. Data recorded with the CMS detector at the LHC are used that correspond to an integrated luminosity of 2.19 .

Studies of and mesons including the observation of the decay in proton-proton collisions at .

Measurements of and mesons are performed using a data sample of proton-proton collisions corresponding to an integrated luminosity of , collected with the CMS detector at the LHC at a centre-of-mass energy of . The analysis studies -wave meson decays into and , where the and mesons are identified using the decays and . The masses of the -wave meson states are measured and the natural width of the state is determined.

Measurement of the top quark mass with lepton+jets final states using collisions at .

The mass of the top quark is measured using a sample of events collected by the CMS detector using proton-proton collisions at at the CERN LHC. Events are selected with one isolated muon or electron and at least four jets from data corresponding to an integrated luminosity of 35.9 .

Search for third-generation scalar leptoquarks decaying to a top quark and a lepton at .

A search for pair production of heavy scalar leptoquarks (LQs), each decaying into a top quark and a lepton, is presented. The search considers final states with an electron or a muon, one or two leptons that decayed to hadrons, and additional jets. The data were collected in 2016 in proton-proton collisions at with the CMS detector at the LHC, and correspond to an integrated luminosity of 35.

Measurement of the weak mixing angle using the forward-backward asymmetry of Drell-Yan events in collisions at 8 .

A measurement is presented of the effective leptonic weak mixing angle ( ) using the forward-backward asymmetry of Drell-Yan lepton pairs ( and ) produced in proton-proton collisions at at the CMS experiment of the LHC. The data correspond to integrated luminosities of 18.8 and in the dimuon and dielectron channels, respectively, containing 8.

Measurement of charged particle spectra in minimum-bias events from proton-proton collisions at .

Pseudorapidity, transverse momentum, and multiplicity distributions are measured in the pseudorapidity range for charged particles with transverse momenta satisfying in proton-proton collisions at a center-of-mass energy of . Measurements are presented in three different event categories. The most inclusive of the categories corresponds to an inelastic data set, while the other two categories are exclusive subsets of the inelastic sample that are either enhanced or depleted in single diffractive dissociation events.

Observation of Top Quark Production in Proton-Nucleus Collisions.

The first observation of top quark production in proton-nucleus collisions is reported using proton-lead data collected by the CMS experiment at the CERN LHC at a nucleon-nucleon center-of-mass energy of sqrt[s_{NN}]=8.16  TeV. The measurement is performed using events with exactly one isolated electron or muon candidate and at least four jets.

Quantitative Proteomic Analysis of the Hippocampus of Rats with GCR-Induced Spatial Memory Impairment.

NASA is planning future missions to Mars, which will result in astronauts being exposed to ∼13 cGy/year of galactic cosmic radiation (GCR). Previous ground-based experiments have demonstrated that low (15 cGy) doses of 1 GeV/n Fe ions impair hippocampus-dependent spatial memory in rats. However, some irradiated rats maintain a spatial memory performance comparable to that seen in the sham-irradiated rats, suggesting that some of these animals are able to ameliorate the deleterious effects of the GCR, while others are not.

Voice and swallowing outcomes following reoperative anterior cervical discectomy and fusion with a 2-team surgical approach.

OBJECTIVE Dysphagia and vocal cord palsy (VCP) are common complications after anterior cervical discectomy and fusion (ACDF). The reported incidence rates for dysphagia and VCP are variable. When videolaryngostroboscopy (VLS) is performed to assess vocal cord function after ACDF procedures, the incidence of VCP is reported to be as high as 22%.

Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.

Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the past 30 years. In our effort to identify potent and isoform-selective histone deacetylase (HDAC) inhibitors as a therapeutic approach to melanoma, a series of new HDAC6 inhibitors based on the nexturastat A scaffold were prepared. The new analogues , , and bearing added hydrophilic substituents, so as to establish additional hydrogen bonding on the rim of the HDAC6 catalytic pocket, exhibit improved potency against HDAC6 and retain selectivity over HDAC1.

The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats.

Objective: Long-term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain.

Methods: Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control.

Obese (Body Mass Index >30) Patients Have Greater Functional Improvement and Reach Equivalent Outcomes at 12 Months Following Decompression Surgery for Symptomatic Lumbar Stenosis.

Objective: To evaluate effect of obesity on 12-month functional outcomes after surgery for lumbar stenosis in adult patients.

Methods: Data were collected on patients treated with lumbar laminectomy for symptomatic lumbar spinal stenosis as part of an observational registry and analyzed using a retrospective cohort study design. Patients with body mass index (BMI) >30 were compared with patients with BMI <30 with respect to baseline, 3-month, and 12-month functional status, adjusted for potential confounders.

Localization of the corticospinal tract within the porcine spinal cord: Implications for experimental modeling of traumatic spinal cord injury.

Spinal cord injury (SCI) researchers have predominately utilized rodents for SCI modeling and experimentation. Unfortunately, a large number of novel therapies developed in rodent models have failed to demonstrate efficacy in human clinical trials which suggests that improved animal models are an important translational tool. Recently, porcine models of SCI have been identified as a valuable intermediary model for preclinical evaluation of promising therapies to aid clinical translation.

Management of acute traumatic spinal cord injuries.

Acute traumatic spinal cord injury (SCI) is a devastating disease process affecting tens of thousands of people across the USA each year. Despite the increase in primary prevention measures, such as educational programs, motor vehicle speed limits, automobile running lights, and safety technology that includes automobile passive restraint systems and airbags, SCIs continue to carry substantial permanent morbidity and mortality. Medical measures implemented following the initial injury are designed to limit secondary insult to the spinal cord and to stabilize the spinal column in an attempt to decrease devastating sequelae.

Changes in the Hippocampal Proteome Associated with Spatial Memory Impairment after Exposure to Low (20 cGy) Doses of 1 GeV/n Fe Radiation.

Exposure to low (∼20 cGy) doses of high-energy charged (HZE) particles, such as 1 GeV/n Fe, results in impaired hippocampal-dependent learning and memory (e.g., novel object recognition and spatial memory) in rodents.

Spatial Memory Performance of Socially Mature Wistar Rats is Impaired after Exposure to Low (5 cGy) Doses of 1 GeV/n Ti Particles.

Prolonged deep space missions to planets and asteroids will expose astronauts to galactic cosmic radiation (GCR), a mixture of low-LET ionizing radiations, high-energy protons and high-Z and energy (HZE) particles. Ground-based experiments are used to determine whether this radiation environment will have an effect on the long-term health of astronauts and their ability to complete various tasks during their mission. Emerging data suggest that mission-relevant HZE doses impair several hippocampus-dependent neurocognitive processes in rodents, but that there is substantial interindividual variation in the severity of neurocognitive impairment, ranging from no observable effects to severe impairment.

Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus.

Increased clinical and scientific scrutiny is being applied to hepatitis B virus (HBV), with focus on the development of new therapeutic approaches, ultimately aiming for cure. Defining the optimum natural CD8+ T cell immune responses that arise in HBV, mediated by HLA class I epitope presentation, may help to inform novel immunotherapeutic strategies. Therefore, we have set out to develop a comprehensive database of these epitopes in HBV, coined 'Hepitopes'.

Cutaneous carcinosarcoma: a series of six cases and a review of the literature.

Background: Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.

Methods: Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.

Performance in hippocampus- and PFC-dependent cognitive domains are not concomitantly impaired in rats exposed to 20cGy of 1GeV/n (56)Fe particles.

NASA is currently conducting ground based experiments to determine whether the radiation environment that astronauts will encounter on deep space missions will have an impact on their long-term health and their ability to complete the various tasks during the mission. Emerging data suggest that exposure of rodents to mission-relevant HZE radiation doses does result in the impairment of various neurocognitive processes. An essential part of mission planning is a probabilistic risk assessment process that takes into account the likely incidence and severity of a problem.