Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-derived Neurotrophic Factor (BDNF).

Introduction: Female Pattern Hair Loss (FPHL) is considered the most common type of hair loss in females. Women with FPHL may suffer from psychological distress and defective social functioning. Patients with psychiatric and neurodegenerative disorders almost have a deficient brain and blood brain-derived neurotrophic factor levels (BDNF).

Search for a two-input model for future investigations of 'synaptic tagging' in freely moving animals in vivo.

Processes of "synaptic tagging" guarantee synaptic input specificity after the induction of a protein synthesis-dependent late long-term potentiation (late-LTP). Distinct high-frequency stimulation can set a transient "synaptic tag" at the activated synapses, which captures plasticity-related proteins (PRPs) synthesized synapse-non-specifically in dendritic branches/compartments or the somata. Thus, only those synapses, which expressed a "tag", are also able to express late-LTP.

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse.