Publications by authors named "Hadil M Al Muhisen"
G3 (Bethesda)
February 2022
Article Synopsis
- The HMGA2 protein is crucial for binding DNA and regulating transcription, with its absence causing dwarfism in mice and rabbits.
- CRISPR/Cas9 was utilized to create a specific mouse model with Hmga2 knocked out, which led to significant reductions in body size and infertility in both male and female mice.
- Despite the reduction in body size and changes in reproductive organs, Hmga2-/- mice had normal testis histology and showed altered behaviors, indicating HMGA2’s important role in growth regulation and behavioral functions.
