Publications by authors named "Hadi-Sedigh Ebrahim-Saraie"

Background: Modern dental caries prevention methods have focused on using herbal products that ideally inhibit the critical cariogenic bacteria (). The present study compared antibacterial efficacy of the resveratrol herbal extract and 0.12% chlorhexidine (CHX) against Streptococcus mutans ().

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Introduction: Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which appeared in 2019, has been classified as critical and non-critical according to clinical signs and symptoms. Critical patients require mechanical ventilation and intensive care unit (ICU) admission, whereas non-critical patients require neither mechanical ventilation nor ICU admission. Several factors have been recently identified as effective factors, including blood cell count, enzymes, blood markers, and underlying diseases.

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In the ongoing challenge to reduce burn-associated mortality rates, this study explores the predictive capacity of clinical factors in burn patients, focusing on vitamin D, calcium, and serum albumin levels during hospitalisation in cases with Pseudomonas aeruginosa infection. Our research involves a comprehensive analysis of 100 burn patients, encompassing crucial clinical parameters such as the burn severity index, serum albumin, vitamin D, and calcium levels at admission. Data were meticulously entered into IBM Statistics SPSS software version 28 and subjected to statistical analysis.

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Background: Aluminum phosphide (ALP) poisoning is considered one of the health care issues in Iran, which is associated with the mortality outcome of patients.

Introduction: According to the ALP poisoning that commonly results in death, we aimed to evaluate the prevalence of ALP pill poisoning by employing register-based research.

Methods: In this descriptive cross-sectional study, all selected patients diagnosed and confirmed with ALP poisoning by a specialist and referred to the poisoning ward from the beginning of April 2016 to the end of October 2017 were enrolled, and data were registered in the Disease Registration System by a technical expert for daily follow-up during hospitalization.

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Article Synopsis
  • * A systematic review was conducted using data from various research databases, resulting in the analysis of seven relevant studies published from 2010 to 2017.
  • * The findings indicate that the overall prevalence of invasive infections among hospitalized Iranian children is low at 2.5%, highlighting the need for more research, particularly in eastern regions.
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Purpose: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which may play a role in the development of gastric cancer (GC). This study aimed to investigate the association of five TNF-α polymorphisms including TNF-α-857, TNF-α-1031, TNF-α-863, TNF-α-308, and TNF-α-238 polymorphisms with GC risk.

Methods: All eligible case-control studies were collected by searching PubMed, Scopus, and Web of Science.

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global outbreak of coronavirus disease 2019 (Covid-19), which has been considered as a pandemic by WHO. SARS-CoV-2 encodes four major structural proteins, among which spike protein has always been a main target for new vaccine studies. This in silico study aimed to investigate some physicochemical, functional, immunological, and structural features of spike protein using several bioinformatics tools.

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  • - The study investigates how common Pseudomonas aeruginosa, a harmful bacteria, is among Cystic Fibrosis patients in Iran, analyzing 14 articles up to July 2019 using various scientific databases.
  • - The findings reveal that the overall prevalence of P. aeruginosa in these patients is 40.6%, with significant variation across different studies.
  • - The researchers emphasize the need for further investigation into the risk factors and transmission of P. aeruginosa due to its serious health impacts on Cystic Fibrosis patients.
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Objective: The present study aimed to investigate the frequency and antibiotic susceptibility pattern of Gram-negative bacteria (GNB) isolated from surgical site infections (SSIs) in the North of Iran.

Results: This cross-sectional study conducted over a two-year period during 2018-2020 on all cases of SSIs who had a positive culture for a GNB. Standard microbiological tests were followed for the bacterial isolation and identification.

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Purpose: The pathogenesis of Pseudomonas aeruginosa is multifactorial and attributed to the production of several cell-associated and extracellular virulence factors including those implicated in adherence, iron uptake, exoenzymes (Exo) and exotoxins. The present study aimed to determine the prevalence of type III secretion systems (T3SS) effectors in Iranian burn patients with P. aeruginosa wound infection.

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sequence type (ST) 131 is considered a high-risk pandemic clone and frequently extended-spectrum β-lactamase (ESBL)-producing clone that is strongly associated with the global dissemination of CTX-M-15 type. The emergence of ST131 has become a public health threat because this clonal group typically exhibits multiple virulence factors and antimicrobial resistance. Therefore, this study aimed to analyze the literature published on the estimation of the prevalence of clone ST131 among strains isolated from patients with urinary tract infections in western Asia.

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Objectives: infection as a healthcare-associated infection can cause life-threatening infectious diarrhea in hospitalized patients. The aim of this study was to investigate the toxin profiles and antimicrobial resistance patterns of isolates obtained from hospitalized patients in Shiraz, Iran.

Materials And Methods: This study was performed on 45 toxigenic isolates.

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The present systematic review and meta-analysis study aimed to investigate the prevalence of class 1 integrons and their associated antibiotic resistance in uropathogenic A systematic search was conducted to identify studies meeting our inclusion criteria in the Web of Science, PubMed, Embase, Scopus, and Google Scholar electronic databases to the end of July 2019. Finally, 35 articles were selected for data extraction, and meta-analysis was performed using the metaprop program in the STATA, version 11.0, software.

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This study was aimed to evaluate occurrence of antibiotic resistance and the presence of resistance determinants among clinical isolates of Acinetobacter baumannii. This cross-sectional study from January to September 2018 was performed on 59 A. baumannii strains isolated from clinical samples in the north of Iran.

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Background: is the most common causes of hospital-acquired diarrhea affecting particularly hospitalized patients globally. This organism has re-emerged in recent years with significant morbidity and mortality. The present study aimed to estimate the burden of infection (CDI) and to acquire information on the overall rates of community- and hospital-acquired CDI in western Asia.

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Objectives: has emerged as an important opportunistic nosocomial pathogen due to its intrinsic and acquired resistance to a wide range of antimicrobial agents. The present study aimed to investigate the occurrence of antibiotic resistance and resistance mechanisms among clinical isolates of from Iranian patients.

Materials And Methods: This cross-sectional study was performed on 44 isolates that were recovered from different clinical specimens in 2015 and 2016.

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Article Synopsis
  • Quinolones are synthetic antibiotics often used to treat urinary tract infections (UTIs), and this study assessed the resistance prevalence and PMQR genes among UTI isolates.
  • The analysis involved 121 isolates tested for susceptibility to various quinolones, revealing a high resistance rate, particularly against nalidixic acid (71.9%) and lower against norfloxacin (44.6%).
  • The study concluded that while there is significant quinolone resistance among UTI strains in southern Iran, the identified PMQR genes do not seem to be the primary drivers of this resistance.
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  • * A study looked at published research between 2000 and 2017 to see how well a drug called tedizolid works against MRSA, finding that most MRSA strains were sensitive to it.
  • * The study showed that while tedizolid works well against MRSA, more research is needed to confirm these findings and help people in real-life situations.
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  • * Researchers tested 39 isolates (18 A. baumannii and 21 P. aeruginosa) taken from hospitalized patients in southern Iran, finding that all tested strains of A. baumannii were resistant to imipenem and ceftazidime, while both types of bacteria were susceptible to colistin.
  • * Results showed that colistin had strong in vitro activity, with encouraging minimum inhibitory concentrations, suggesting it could be a useful treatment option for drug-resistant infections; however, more extensive studies are needed for confirmation.
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Clostridium difficile (recently Clostridioides difficile) is a leading cause of hospital- and antimicrobial-associated diarrhea (AAD). The present study was carried out to investigate the prevalence of toxigenic C. difficile, antibiotic resistance and its associated risk factors in Iranian hospitalized patients.

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Background: and as an obligate human pathogen are two common causes of sexually transmitted diseases (STDs). The present study aimed to determine the prevalence of and among human immunodeficiency virus (HIV) patients in the southwest Iran.

Methods: This retrospective study was performed from 2004 to 2013, on HIV patients who were tested for detection of gonorrhea and syphilis infection at Shiraz HIV/AIDS Research Center.

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Multiple drug-resistant enterococci are major cause of healthcare-associated infections due to their antibiotic resistance traits. Among them, is an important opportunistic pathogen causing various hospital-acquired infections. A total of 53 isolates were obtained from various infections.

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Background: Urinary tract infections (UTIs) are one of the most frequent diseases encountered by humans worldwide. The presence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) harboring several virulence factors, is a major risk factor for inpatients. We sought to investigate the rate of antibiotic resistance and virulence-associated genes among the UPECs isolated from an Iranian symptomatic population.

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Article Synopsis
  • The study analyzed resistance to MLS antibiotics in 164 staphylococci isolates from two hospitals in Shiraz, Iran, over a six-month period.
  • Among the erythromycin-resistant isolates, 35 were Staphylococcus aureus and 51 were coagulase-negative staphylococci, with varying percentages of constitutive (cMLS), inducible (iMLS), and macrolide-streptogramin (MS) resistance.
  • The predominant resistance genes found were ermC in both types of staphylococci, highlighting the need for routine screening for MLS resistance in clinical settings.
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