Publications by authors named "Hadi Zafarmand"
Article Synopsis
- Childhood aggressive behavior (AGG) is significantly heritable, with around 50% of its variation attributed to genetics, as shown in a study analyzing data from over 87,000 children aged 1.5 to 18 years; however, no genome-wide significant SNPs were identified.* -
- Three significant genes (ST3GAL3, PCDH7, and IPO13) linked to educational traits were found, and genetic analysis revealed moderate to strong correlations between AGG and various psychiatric traits, with notable weak correlations concerning teacher assessments.* -
- The research also showed negative genetic correlations of aggression with cognitive abilities and age at first birth, alongside strong correlations with smoking behaviors, highlighting complex genetic interactions within childhood aggression.*
Genetic predisposition of social sensitivity might affect vulnerability to develop psychopathology after early life stress exposure. This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire.
View Article and Find Full Text PDFTo identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide significance. In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.
View Article and Find Full Text PDFHeight is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and uncommon SNPs with adult height in 114,223 individuals from 47 studies and six ethnicities. A total of 64 loci contained a SNP associated with height at array-wide significance (p < 2.
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