p53 overexpression impacts on the prognosis of laryngeal squamous cell carcinomas.

Objectives: To investigate the prognostic implications of p53 expression in the surgical margins of laryngeal squamous cell carcinomas.

Methods: Thirty one patients with T3-4N0M0 cancers with pathologically negative margins were analyzed by immunohistochemistry (IHC) to detect expression of p53.

Results: The p53 positive rates by IHC in the surgical margin were 16.