Publications by authors named "Hadi Razeghifam"
Recent Pat Biotechnol
December 2021
Article Synopsis
- Methotrexate (MTX) is a chemotherapy drug that can cause kidney damage at high doses, but glucarpidase, produced by engineered E. coli, helps mitigate this issue.
- The study aimed to identify suitable signal peptides (SPs) for secreting glucarpidase from E. coli using bioinformatics tools.
- Results showed that two specific SPs, PPB and TIBA, can effectively translocate glucarpidase outside the cell, although further experimental validation is needed to confirm these findings.
