Synopsis of recent research by authors named "Hadi Molanaei"
- Hadi Molanaei's research focuses on the impact of inflammation on drug metabolism among hemodialysis patients, particularly examining the role of cytochrome P450 enzymes such as CYP3A4 and CYP2D6 in pharmacokinetics within this population.
- His studies have demonstrated that inflammation can significantly down-regulate the metabolism of drugs like quinine and alprazolam, indicating that persistent inflammation alters pharmacokinetics in hemodialysis patients.
- Additionally, he investigated the relationship between C-reactive protein levels during dialysis sessions and mortality, finding no association, and explored the effects of genetic polymorphisms on drug disposition in patients with end-stage renal disease.