Publications by authors named "Hadi Kabalane"
In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively. It is debated which of these two temporally separate steps determines origin efficiency.
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- The study investigates how DNA replication and gene expression differ between cancerous and non-cancerous human cell types during development, revealing significant alterations in cancer.
- Changes in replication fork directionality (RFD) are common, especially in GC-poor isochores, and are mostly independent of transcriptional changes; cancer cells exhibit RFD profiles similar to non-cancer cells from the same developmental origin.
- Specifically, in chronic myeloid leukemia (CML), prolonged expression of the BCR-ABL1 oncogene leads to a significant shift in replication initiation zones, demonstrating a preference for downregulation and impacting the stability of certain DNA regions throughout cancer progression.