Non-cannulated versus cannulated cancellous screws for the internal fixation of femoral neck fractures in osteoporotic patients: A single-blind randomized clinical trial.

Background: The incidence of femoral neck fractures in osteoporotic patients is rising worldwide and is associated with significant increases in healthcare and social costs, as well as dependency. Improving minimally invasive treatment strategies, including internal fixation with screws, can result in favorable clinical outcomes and lesser incidence of complications, while preserving the hip. This study compared the outcomes of using non-cannulated cancellous screws (NCS) and cannulated cancellous screws (CS) in the internal fixation of undisplaced intracapsular femoral neck fractures (UIFNF) of osteoporotic patients of Iranian descent.

Impacts of the COVID-19 pandemic on the social sphere and lessons for crisis management: a literature review.

The COVID-19 pandemic is the most difficult challenge that has affected humanity in recent decades. It has disrupted many features of development with domino effects in the social sphere. This study reviews the literature on the social effects of the COVID-19 pandemic and identifies the affected social areas that have undergone dramatic changes during the pandemic.

Identifying drivers affecting air quality in metropolitan areas of developing countries: evidence from Tehran metropolitan area.

Environmental issues and the significant reduction of air quality in the metropolitan areas of developing countries have become chronic challenges. While the impacts of many reasons such as the rapid trend of urbanization, lacking sustainable thinking in urban planning approaches, and urban sprawl have been explored in previous literature, the role of political economy, especially the structure based on the rentier economy, in the change of air quality as an environmental challenge in the metropolitan areas of developing countries has received little attention. To fill this gap, this study focuses on the role of the rentier economy and identifies the drivers based on it that have a tremendous impact on the air quality in Tehran metropolitan area, Iran.

The Sensitivity of Tau Tracers for the Discrimination of Alzheimer's Disease Patients and Healthy Controls by PET.

Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron emission tomography (PET) began with the development of [F]FDDNP, an amyloid β tracer with off-target binding to tau, which obtained regional specificity through the differing distributions of amyloid β and tau in AD brains. A concerted search for more selective and affine tau PET tracers yielded compounds belonging to at least eight structural categories; F-flortaucipir, known variously as [F]-T807, AV-1451, and Tauvid, emerged as the first tau tracer approved by the American Food and Drug Administration.

The neural effects of oxytocin administration in autism spectrum disorders studied by fMRI: A systematic review.

Purpose: Oxytocin (OXT) is a hypothalamic neuropeptide that is released from the posterior pituitary gland and at specific targets in the central nervous system (CNS). The prosocial effects of OXT acting in the CNS present it as a potential therapeutic agent for the treatment of aspects of autism spectrum disorder (ASD). In this article, we systematically review the functional MRI (fMRI) literature that reports task-state and resting-state fMRI (rsfMRI) studies of the neural effects of single or multiple dose intranasal OXT (IN-OXT) administration in individuals with ASD.

Analysis of the state of social resilience among different socio-demographic groups during the COVID- 19 pandemic.

This study examines social resilience during the COVID-19 pandemic by analyzing the state of selected indicators among different Socio-Demographic Groups (SDGs) in Tehran, the capital city of Iran. Data were collected via a questionnaire survey. The survey was administered between January and April 2021 and the total number of properly completed questionnaires was 786.

Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Background: Lymphocyte to monocyte ratio (LMR) is a surrogate marker of systemic inflammation which is shown to be related to the patient's survival in multiple malignancies. An important implication of this marker potentially is neoplasms in which there is no correlation between prognosis and histopathological staging and also has no reliable chemical markers associated with prognosis. Herein, this meta-analysis aimed to investigate the prognostic role of LMR in patients with hepatocellular carcinoma (HCC).

Deconstruction of the human connexin 26 hemichannel due to an applied electric field; A molecular dynamics simulation study.

Connexins are a 21-member membrane protein family constituting channels evolved in direct communication between adjacent cells by passaging cytoplasmic molecules and ions. Hexametrical assembly of connexin proteins in plasma membrane forms a wide aqueous pore known as connexin hemichannel. These hemichannels mediate cytoplasm and extracellular milieu communication both in many external tissues and in the central nervous system.