Changes in cardiac output and its distribution after non-haemorrhagic injury in the rat.

In the unanaesthetized rat cardiac output, measured by a thermodilution technique, fell rapidly following a 4h period of bilateral hind-limb ischaemia. There was a significant positive correlation between body temperature and total cardiac output after injury. There were also striking changes in the distribution of cardiac output; for example, hepatic artery flow was markedly increased, whereas splanchnic flow fell passively with the reduction in cardiac output.

Studies on the mechanism of shock. Central serotoninergic neuron activity after trauma in the rat.

An attempt has been made to assess the effect of injury (limb ischaemia, scald) on the central serotoninergic system of the rat by studying the effect of these injuries on the tryptophan concentration, the tryptophan hydroxylase activity and the metabolism of serotonin in the hypothalamus, mid-brain and hind-brain. The effects of a serotonin uptake inhibitor and an antagonist on the survival time and mortality rate after limb ischaemia have been examined as well as the effects of central lesions produced by the injection of 5.6- and 5.

Rifampicin-induced thrombocytopenia.

Rifampicin occasionally causes thrombocytopenia when given as part of an intermittent regimen. A case is reported of severe thrombocytopenia developing after one dose of rifampicin, following a 4-month gap in daily therapy. The literature on rifampicin-induced thrombocytopenia is reviewed.

Chlorodimeform and its effect on monoamine oxidase activity in the cattle tick, Boophilus microplus.

The action of the acaricide, chlorodimeform and its metabolite. N-desmethylchlorodimeform, on the activity monoamine oxidase (MAO) from the cattle tick, Boophilus microplus, were studied. Both compounds were found to be potent in vitro and in vivo inhibitors of the enzyme.